Global burden of bacterial skin diseases from 1990 to 2045: an analysis based on global burden disease data.

Bacterial skin diseases are a category of inflammatory skin conditions caused by bacterial infections, which impose a significant global disease burden. However, they have not been well assessed or predicted on a global scale. It is necessary to update the estimates and forecast future trends of the global burden of bacterial skin diseases to evaluate the impact of past healthcare policies and to provide guidance and information for new national and international healthcare strategies.

Biodegradable Tenebrio molitor antifreeze protein modified kinetic hydrate inhibitor: Insights into molecular interactions and structural flexibility.

The formation of natural gas hydrates presents significant economic and safety challenges to the petroleum and gas industry, necessitating the development of effective prevention strategies. This study investigates an environmentally sustainable Tenebrio molitor antifreeze protein (TmAFP) modified to be a potential kinetic hydrate inhibitor. The aim of this study was to enhance the inhibitory activity of TmAFP by systematically substituting threonine (Thr) residues with glycine (Gly), alanine (Ala), or serine (Ser) at positions 29, 39, and 53.

Dectin-1 as a therapeutic target for inflammatory bowel disease.

Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the distal gastrointestinal tract, including Crohn's disease and ulcerative colitis. This chapter explores the potential of Dendritic cell-associated C-type lectin-1 (Dectin-1), a pattern recognition receptor, as a therapeutic target for IBD. We delve into the multifaceted roles of Dectin-1 in immune response modulation, focusing on its interactions with the gut microbiota and immune system.

Effect of sarcopenia on liver cirrhosis with complicating oesophageal and gastric varices after endoscopic therapy.

Several investigators have reported that sarcopenia is common in patients with liver cirrhosis. However, few studies have probed the association between sarcopenia and liver cirrhosis complicated with oesophageal and gastric variceal bleeding (LC-EGVB). We aimed to investigate the impact of sarcopenia on rebleeding after endoscopic therapy in patients with LC-EGVB.

Spatial distribution patterns and factors influencing rural tourism destinations: An empirical study of China's agritainment resorts.

Agritainment is one of the essential aspects of rural tourism and plays an important role in the economic transformation and revitalization of rural areas. Taking 9200 agritainment resorts in China as a research object, this paper systematically uses geospatial analysis methods to analyze their spatial distribution patterns and influencing mechanisms. The results indicate: (1) All types of agritainment have a condensed distribution in space and are oriented in the northeast-southwest direction, with a central axis generally located in the Beijing-Zhengzhou-Wuhan line.

Propylene glycol alginate sodium sulfate suppressed lung metastasis by blocking P-selectin to recruit CD4 regulatory T cells.

P-selectin has been shown to enhance growth and metastasis of mouse tumors by promoting regulatory T cell (Treg) infiltration into the tumors. Theoretically, a P-selectin antagonist could suppress the process. Popylene glycol alginate sodium sulfate (PSS) is a heparin-like marine drug, which was originally approved to treat cardiovascular disease in China.

Design of eco-friendly antifreeze peptides as novel inhibitors of gas-hydration kinetics.

In this study, peptides designed using fragments of an antifreeze protein (AFP) from the freeze-tolerant insect Tenebrio molitor, TmAFP, were evaluated as inhibitors of clathrate hydrate formation. It was found that these peptides exhibit inhibitory effects by both direct and indirect mechanisms. The direct mechanism involves the displacement of methane molecules by hydrophobic methyl groups from threonine residues, preventing their diffusion to the hydrate surface.

Biomedical named entity recognition based on multi-cross attention feature fusion.

Currently, in the field of biomedical named entity recognition, CharCNN (Character-level Convolutional Neural Networks) or CharRNN (Character-level Recurrent Neural Network) is typically used independently to extract character features. However, this approach does not consider the complementary capabilities between them and only concatenates word features, ignoring the feature information during the process of word integration. Based on this, this paper proposes a method of multi-cross attention feature fusion.

Association between risk of preterm birth and long-term and short-term exposure to ambient carbon monoxide during pregnancy in chongqing, China: a study from 2016-2020.

Background: Preterm birth (PTB) is an important predictor of perinatal morbidity and mortality. Previous researches have reported a correlation between air pollution and an increased risk of preterm birth. However, the specific relationship between short-term and long-term exposure to carbon monoxide (CO) and preterm birth remains less explored.

Influence of mentoring on the proactive behavior of new employees: moderated mediation effect of agreeableness.

Objective: In recent years, faced with a complex economic development environment and the evolving dynamics of the Chinese workplace, talent has become a precious resource that is invaluable yet scarce for every enterprise. As Generation Z employees have gradually entered the labor market, they contribute new perspectives and energies to various enterprises and pose unique challenges. The traditional step-by-step approach no longer meets the needs of today's businesses.

Antibacterial Hydrophilic ZnO Microstructure Film with Underwater Oleophobic and Self-Cleaning Antifouling Properties.

Super-hydrophilic and oleophobic functional materials can prevent pollution or adsorption by repelling oil, and have good circulation. However, traditional strategies for preparing these functional materials either use expensive fabrication machines or contain possibly toxic organic polymers, which may prohibit the practical application. The research of multifunctional ZnO microstructures or nanoarrays thin films with super-hydrophilic, antifouling, and antibacterial properties has not been reported yet.

Salinity-dependent top-down effect of rotifer Brachionus plicatilis on removing harmful alga Phaeocystis globosa.

Using appropriate zooplankton to transfer the primary productivity of harmful algae to higher trophic levels through food chain is an eco-friendly mode to remove harmful algae. To assess the top-down efficiency of rotifer removing Phaeocystis and the salinity effect, we adopted a series of salinities to carry out Phaeocystis-rotifer population dynamics and rotifer life-history experiments. Results showed that the time for rotifers to remove Phaeocystis population was the shortest when the salinity was ≤20 ‰.

Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis.

Background: The incidence rate of malignant tumors after solid organ transplantation is higher than the normal population. The aim of our study is to identify the risk of renal cell carcinoma (RCC) after liver, kidney, heart and lung transplantation, respectively, and suggest that transplant patients can be screened early for tumors to avoid risk.

Methods: PubMed, Embase and the Cochrane Library from their inception until August 16,2023.

Sex Differences in Diet and Physical Activity Behaviors Among Racial/Ethnic Minority Adolescents with High Metabolic Risk.

Certain dietary and physical activity (PA) behaviors may differentially predispose male and female adolescents to obesity and diabetes; however, sex differences in dietary and PA behaviors and in factors that impact these behaviors (e.g., self-efficacy, social support) in this population remain unknown.

Subjective and Objective Hearing Loss Among US Adult Cancer Survivors.

Importance: Cancer survivors are at a higher risk of developing hearing loss (HL) due to older age, chemotherapy, and radiotherapy. However, the prevalence of HL among US cancer survivors remains unknown. Additionally, there is a lack of uniform HL screening guidelines for this enlarging population.

Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.

Background: Astrocytes play a vital role in offering functional support for neurons, which are related to the pathogenic mechanism of depression. Ginsenoside Rb1 (GRb1) is demonstrated with antidepressant-like activities.

Purpose: We aimed to investigate whether GRb1 can inhibit mitophagy-mediated astrocytic pyroptosis to protect neurons in depression.

Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting β-tubulin.

Plinabulin is a promising microtubule destabilizing agent in phase 3 clinical stage for treating non-small cell lung cancer. However, the high toxicity and the poor water solubility of plinabulin limited its use and more plinabulin derivatives need to be explored. Here, two series of 29 plinabulin derivatives were designed, synthesized and evaluated for their anti-tumor effect against three types of cancer cell lines.

Association between High Ambient Temperatures and Road Crashes in an Australian City with Temperate Climate: A Time-Series Study, 2012-2021.

(1) Background: High ambient temperatures are associated with increased morbidity and mortality rates, and some evidence suggests that high temperatures increase the risk of road crashes. However, little is known regarding the burden of road crashes attributable to no-optimal high temperatures in Australia. Therefore, this study examined the effects of high temperatures on road crashes using Adelaide in South Australia as a case study.

Comfort levels in discussing tobacco smoking among hospital staff in a children's hospital.

Introduction: Hospital staff discussing smoking with children and their families can impact tobacco control, which is crucial in reducing the harmful effects of tobacco smoke exposure. Our study aims to assess staff comfort level in discussing smoking with patients or their families, and coworkers, after the implementation of a hospital-wide tobacco control policy.

Methods: This cross-sectional study included 2340 staff members who completed an anonymous online survey in a large urban children's hospital in 2019.

First record of the flat-skulled woolly bat and the Indochinese woolly bat (Chiroptera, Vespertilionidae) in China.

Recent studies have revealed that the complex should be divided into two species, distributed mainly in Myanmar, Vietnam, Laos and Cambodia, and found only in the Annamite Mountains of Vietnam, Laos and Cambodia. In November 2018 and April 2019, 24 woolly bats were collected by two-band harp traps in Xishuangbanna, Yunnan, China. Based on morphological, morphometric, and phylogenetic (, , and gene sequences) analyses, these bats were identified as and , representing two new species records for the country.

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China.

Introduction: There have been many researches done on the association between maternal exposure to ambient air pollution and adverse pregnancy outcomes, but few studies related to very low birth weight (VLBW). This study thus explores the association between maternal exposure to ambient air pollutants and the risk of VLBW, and estimates the sensitive exposure time window.

Methods: A retrospective cohort study analyzed in Chongqing, China, during 2015-2020.