Implication of MYH in colorectal polyposis.

Objective: The aim of this study was to determine the frequency of MYH mutations in one large population of polyposis patients without APC mutation identified.

Summary Background Data: Familial adenomatous polyposis (FAP) is the most known inherited colorectal cancer syndrome. In 70% to 80% of polyposis patients, an APC mutation is found.

Effects of preoperative radiotherapy for primary resectable rectal adenocarcinoma on male sexual and urinary function.

Purpose: The purpose of this study was to determine whether preoperative radiotherapy had an influence on the urinary and sexual function of patients having a sphincter-saving, nerve-preserving total mesorectal excision.

Methods: Urinary and sexual function of male patients undergoing sphincter-saving, nerve-preserving total mesorectal excision for primary resectable rectal carcinoma between January 1998 and December 1999 were evaluated retrospectively. Assessment was by standardized questionnaires.