Repairable body-centered cubic Fe anchoring on porous hollow nitrogen-doped carbon spheres with adjusting electron distribution for efficient electrocatalytic ammonia synthesis.

Electrocatalytic nitrogen reduction reaction (ENRR) is a promising and efficient method for ammonia production. However, ENRR is restricted by the adsorption and activation of N. Herein, an efficient nitrogen reduction reaction (NRR) electrocatalyst loaded with zero valent iron (ZVI) particles onto porous nitrogen-doped carbon (NC) hollow spheres is reported.

In-situ construction of WS/ZIF-8 composites with an electron-rich interface for enhancing nitrogen photofixation.

Photocatalytic nitrogen reduction reaction (PNRR) is an environmentally friendly synthesis method. It has been regarded as a promising approach for future NH preparation, which can reduce the natural fuel consumption and pollution of the Haber Bosch process. Nevertheless, this method exists poor activity for mass production, so it is urgent but challenging to explore highly efficient catalysts.

Uric acid promotes interleukin-17 expression to cause kidney injury.

Uric acid, an oxidation end-product of purine metabolism, is reportedly to be a risk factor for kidney injury. However, its underlying mechanism is still a mystery. This study aimed to reveal the detailed roles of uric acid in inducing kidney injury and the possible mechanisms.

Influence of COVID-19 for delaying the diagnosis and treatment of pulmonary tuberculosis-Tianjin, China.

Background: The COVID-19 pandemic has disrupted the diagnosis, treatment, and care for tuberculosis (TB). Delays in seeking TB care may result in increased community transmission and unfavorable treatment outcomes. We sought to understand the influence of the COVID-19 pandemic on the proportion of patients with TB who delayed seeking the diagnosis and care for TB and explore the reasons for their postponement.

Aerobic degradation of bisphenol A by Pseudomonas sp. LM-1: characteristic and pathway.

Bisphenol A (BPA) has been widely used in the manufacture of polymeric materials. BPA is regarded as an endocrine disrupting chemical, posing a great threat to the public health. In this study, a bacterial strain LM-1, capable of utilizing BPA as the sole carbon and energy source under aerobic conditions, was originally isolated from an activated sludge sample.

Effects of different growth patterns of Tamarix chinensis on saline-alkali soil: implications for coastal restoration and management.

Objective: To better understand the wetland restoration, the physicochemical property and microbial community in rhizosphere and bulk soil of the living and death Tamarix chinensis covered soil zones were studied.

Results: There were differences between growth conditions in the levels of soil pH, salinity, SOM, and nutrient. The living status of T.

Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway.

Background Ketamine-related cystitis (KC) has been researched in many clinical studies, but its exact mechanism is ambiguous and needs further research. Methods We established a KC rat model and analyzed physiological, biochemical, and urodynamic parameters of ketamine (KET)-related bladder injury. Bladder histologic feature, reactive oxygen species (ROS), autophagy-, apoptosis-, and endoplasmic reticulum stress (ERS)-related markers were examined by hematoxylin and eosin staining, Masson staining, ROS kit, quantitative real-time polymerase chain reaction, and western blot.

Long non-coding RNA CDKN2B-AS1 regulates high glucose-induced human mesangial cell injury via regulating the miR-15b-5p/WNT2B axis.

Background: Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) has been reported to be related to diabetic nephropathy (DN) progression. However, the regulatory mechanisms of CDKN2B-AS1 in DN are unclear.

Methods: High glucose (HG) was used to induce human mesangial cells (HMCs) for establishing the DN model.

The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice.

Background: Sepsis is an inflammatory response undergoing the complicate pathophysiological changes for host defense against pathogens. Previous studies suggested that dexmedetomidine (DEX) was served to controlling the over-reactive inflammatory effects to protect from the sepsis-induced organ failure via modulating histone methylation. However, the genome-wide changes of histone methylations upon DEX for sepsis treatment were poorly explored.

Peritonitis in Peritoneal Dialysis in Northern China: A Case Report.

Fungal peritonitis is a catastrophic complication of peritoneal dialysis (PD) and often requires termination of PD. It is usually caused by species. Here we report a rare case of peritonitis.

Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China.

CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)D concentration and impacting on carcinogenesis. A case-control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes were tested by TaqMan Genotyping Assays.

Dietary factors and microRNA-binding site polymorphisms in the IL13 gene: risk and prognosis analysis of colorectal cancer.

Long-term dietary intake influences the structure and activity of microorganisms residing in the human gut. The immune response and gut microbiota have a mutual influence on the risk of colorectal cancer (CRC). This study examines the association of gut microbiota-related dietary factors and polymorphisms in the microRNA-binding site of the interleukin 13 gene (IL13) with the risk and prognosis of CRC.

Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients.

Accumulating evidence shows that runt-related transcription factor 3 (Runx3) is a putative tumor suppressor in various types of cancer, the lower levels of which are associated with a less favorable cancer outcome. However, these studies were restricted to primary cancer lesions. Lymph node metastasis (LNM) is a significant factor in determining the prognosis of patients with gastric cancer and is a frequent target of chemotherapy.

Feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory.

Purpose: To investigate the feasibility of high temporal resolution breast DCE-MRI using compressed sensing theory.

Methods: Two experiments were designed to investigate the feasibility of using reference image based compressed sensing (RICS) technique in DCE-MRI of the breast. The first experiment examined the capability of RICS to faithfully reconstruct uptake curves using undersampled data sets extracted from fully sampled clinical breast DCE-MRI data.

Quantitative analysis of clinical dynamic contrast-enhanced MR imaging for evaluating treatment response in human breast cancer.

Purpose: To develop a method that combines a fixed-T1, fuzzy c-means (FCM) technique with a reference region (RR) model (T1-FCM method) to estimate pharmacokinetic parameters without measuring the arterial input function or baseline T1, or T1(0), and to demonstrate its feasibility in the assessment of treatment response to neoadjuvant chemotherapy (NAC) in patients with breast cancer by using data from dynamic contrast material-enhanced magnetic resonance (MR) imaging.

Materials And Methods: This study was approved by the human investigation committees of the two participating institutions. All patients gave written informed consent.

A clinically feasible method to estimate pharmacokinetic parameters in breast cancer.

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is the MRI technique of choice for detecting breast cancer, which can be roughly classified as either quantitative or semiquantitative. The major advantage of quantitative DCE-MRI is its ability to provide pharmacokinetic parameters such as volume transfer constant (Ktrans) and extravascular extracellular volume fraction (ve). However, semiquantitative DCE-MRI is still the clinical MRI technique of choice for breast cancer diagnosis due to several major practical difficulties in the implementation of quantitative DCE-MRI in a clinical setting, including (1) long acquisition necessary to acquire 3D T1(0) map, (2) challenges in obtaining accurate artery input function (AIF), (3) long computation time required by conventional nonlinear least square (NLS) fitting, and (4) many illogical values often generated by conventional NLS method.