Publications by authors named "Yanmin Liu"

The gut microbiota influences host immunity and metabolism, and changes in its composition and function have been implicated in several non-communicable diseases. Here, comparing germ-free (GF) and specific pathogen-free (SPF) mice using spatial transcriptomics, single-cell RNA sequencing, and targeted bile acid metabolomics across multiple organs, we systematically assessed how the gut microbiota's absence affected organ morphology, immune homeostasis, bile acid, and lipid metabolism. Through integrated analysis, we detect marked aberration in B, myeloid, and T/natural killer cells, altered mucosal zonation and nutrient uptake, and significant shifts in bile acid profiles in feces, liver, and circulation, with the alternate synthesis pathway predominant in GF mice and pronounced changes in bile acid enterohepatic circulation.

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Background: Non-cystic fibrosis bronchiectasis is associated with frequent and diverse microbial infections, yet an overall understanding of microbial presence across different disease stages is lacking.

Methods: A meta-analysis assessed lung microbes in adults with non-CF bronchiectasis, collecting data using both culture-based and sequencing approaches through three international databases and three Chinese databases. Subgroups were categorized by disease stage: the stable group (S), the exacerbation group (E), and unclassified data consolidated into the undetermined group (U).

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Background: The acute myocardial infarction (AMI) is a prevalent and severe cardiovascular disease, characterized by its sudden onset, high mortality rate, and unfavorable prognosis. The presence of type 2 diabetes not only signifies a chronic metabolic disorder, but also serves as a catalyst for various cardiovascular and cerebrovascular ailments such as coronary heart disease and stroke. Xining is situated in a region of middle to high altitude and due to its unique geographical environment, coupled with the population's limited health awareness, unequal medical standards and other factors, there remain some AMI patients who are difficult to diagnose early on.

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Introduction: , a leading cause of human infectious diarrhea diseases, foodborne illness, and zoonotic infections, poses a significant health burden.

Methods: A retrospective screening was performed to elucidate the serotype distribution and antimicrobial resistance of 933 human isolates from nine cities (prefectures) in Guizhou province of southwestern China between 2019 and 2023 through slide agglutination and antimicrobial resistance testing.

Results: Fifty-four different serotypes were identified in this study, with .

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Background: Xanthomonas citri subsp. citri is the causal agent of citrus canker, which causes substantial losses in citrus production. Here, we report the role of a polyketide cyclase (PKC) on the virulence in X.

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Background: The genomic landscape of esophageal squamous cell carcinoma (ESCC) has been characterized extensively, but there remains a significant need for actionable targets and effective therapies.

Methods: Here, we perform integrative analysis of genome-wide loss of heterozygosity and expression to identify potential tumor suppressor genes. The functions and mechanisms of one of the candidates, TACC2, are then explored both in vitro and in vivo, leading to the proposal of a therapeutic strategy based on the concept of synthetic lethality.

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Primary biliary cholangitis (PBC) is an autoimmune liver disease. During the diagnostic process, the patient's autoimmune antibodies are routinely examined. Approximately 20% of PBC patients have positive anti-centromere antibody (ACA).

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Background: The Albumin-Bilirubin (ALBI) score and grade are widely used to stratify patients with primary biliary cholangitis (PBC) into different disease statuses and risk levels. Recent studies have increasingly highlighted the role of gut microbiota in autoimmune liver diseases. This study aimed to investigate the differences in gut microbiota among PBC patients with varying ALBI grades.

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Introduction: The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.

Methods: In this multicenter, open-label, randomized controlled trial, eligible pregnant women with HBV DNA of 5.3-9.

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Article Synopsis
  • The study investigates how traditional Chinese medicine's concept of deficiency constitution relates to anemia, specifically examining gut microbiome differences in individuals with this constitution.
  • Deficient constitution individuals exhibited lower hemoglobin levels and distinct gut microbiome profiles, including increased Firmicutes and decreased Bacteroidetes, plus higher microbial diversity.
  • The research suggests that changes in the gut microbiome are linked to worse health outcomes and a higher risk of anemia, potentially due to impacts on intestinal barriers and immune function mediated by short-chain fatty acids and bile acids.
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Ferroptosis is a novel, iron-dependent cell death characterized by the excessive accumulation of ferroptosis lipid peroxides ultimately leading to oxidative damage to the cell membrane. Iron, lipid, amino acid metabolism, and other signaling pathways all control ferroptosis. Numerous bodily tissues experience hypoxia under normal and pathological circumstances.

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The evaluation of pathobiome strains should be conducted at the strain level, involving the identification of the functional genes, while considering the impact of ecological niche and drug interactions. The safety, efficacy, and quality management of live biotherapeutic products (LBPs), especially pathobiome strains, have certain peculiarities. Promising development methods include the recombinant LBP and active metabolites.

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Article Synopsis
  • About 1/3 of primary biliary cholangitis (PBC) patients do not respond well to treatment and show intestinal disturbances, prompting research into the microbiota and metabolites of these patients.
  • A study involving 25 subjects found significant differences in bacteria composition and metabolites between patients with poor response and those who responded well, highlighting specific bacterial changes and 17 altered metabolites linked to bile acid metabolism and immune response.
  • The findings suggest that analyzing gut microbiota and metabolites can help predict poor prognosis in PBC patients and serve as valuable diagnostic tools.
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Objective: To uncover the mechanisms underlying the development of colorectal cancer (CRC), we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and progression.

Methods: We performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis on differentially expressed genes (DEGs), constructed a protein-protein interaction (PPI) network to find the top 10 hub genes, and analyzed their expression in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ). We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western blotting.

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Background: Primary biliary cholangitis (PBC) is associated closely with the gut microbiota. This study aimed to explore the characteristics of the gut microbiota after the progress of PBC to cirrhosis.

Method: This study focuses on utilizing the 16S rRNA gene sequencing method to screen for differences in gut microbiota in PBC patients who progress to cirrhosis.

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Background: Blood stasis constitution in traditional Chinese medicine (TCM) is believed to render individuals more susceptible to metabolic diseases. However, the biological underpinnings of this constitutional imbalance remain unclear.

Methods: This study explored the association between blood stasis constitution, serum metabolic markers including uric acid (UA), high-density lipoprotein cholesterol (HDLC), their ratio (UHR), serum metabolites, and gut microbiota.

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Inorganic phosphorus (Pi) deficiency significantly impacts plant growth, development, and photosynthetic efficiency. This study evaluated 206 rice accessions from a MiniCore population under both Pi-sufficient (Pi) and Pi-starvation (Pi) conditions in the field to assess photosynthetic phosphorus use efficiency (PPUE), defined as the ratio of A to A. A genome-wide association study and differential gene expression analyses identified an acid phosphatase gene (ACP2) that responds strongly to phosphate availability.

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Background & Aims: Association studies have greatly refined the important role of the major histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects of human leucocyte antigen (HLA) polymorphisms on AIH are not well established. The aim of this study is to systematically characterise the association of MHC variants with AIH in our well-defined cohort of patients.

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The root architecture of a range of host plants is altered in response to infection. This work aimed to identify host genes involved in root development during infection. A deficient mutant of the type III secretion system regulator was created in GMI1000.

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Herein, it is reported that a series of trichloromethyl/dichloromethyl substituted benzimidazole derivatives have been synthesized by dechlorination of CCl/CHCl to form polychloromethyl radicals and cyclization with an unactivated olefin under a purple LED lamp. The protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up.

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The multi-objective particle swarm optimization algorithm has several drawbacks, such as premature convergence, inadequate convergence, and inadequate diversity. This is particularly true for complex, high-dimensional, multi-objective problems, where it is easy to fall into a local optimum. To address these issues, this paper proposes a novel algorithm called IMOPSOCE.

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Despite being easy to implement and having fast convergence speed, balancing the convergence and diversity of multi-objective particle swarm optimization (MOPSO) needs to be further improved. A multi-objective particle swarm optimization with reverse multi-leaders (RMMOPSO) is proposed as a solution to the aforementioned issue. First, the convergence strategy of global ranking and the diversity strategy of mean angular distance are proposed, which are used to update the convergence archive and the diversity archive, respectively, to improve the convergence and diversity of solutions in the archives.

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Nasopharyngeal carcinoma (NPC) is a common malignant epithelial tumor of the head and neck that often exhibits local recurrence and distant metastasis. The molecular mechanisms are understudied, and effective therapeutic targets are still lacking. In our study, we found that the transcription factor ZIC2 was highly expressed in NPC.

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