Publications by authors named "Yanmin Cheng"
Objective: Recent studies have shown that the COVID-19 lockdown contributes to the psychological and physical stress of college students, who are forced to adjust to this tough time. The objective of this study was to explore how positive coping behaviors and fear of COVID-19 predicted posttraumatic growth (PTG) among Chinese college students in Wuhan during the latest lockdown.
Method: Chinese college students in Wuhan ( = 982) aged 18-30 were recruited and completed an online survey, which assessed the fear of COVID-19, positive coping, reflective rumination, and PTG.
Apatinib regulates the growth of gastric cancer cells by modulating apoptosis and autophagy.
Naunyn Schmiedebergs Arch Pharmacol
May 2021
Apatinib is a novel, highly selective small-molecule inhibitor of the tyrosine kinase VEGFR-2. Although its safety and efficacy in the treatment of advanced gastric cancer (GC) and other solid tumors have been confirmed, the precise molecular mechanism underlying its efficacy remains unclear. The purpose of this study was to investigate the mechanism by which apatinib regulates the biological functions of GC cells in vitro.
View Article and Find Full Text PDFArticle Synopsis
- TOX is a DNA-binding protein that serves as a transcription factor crucial for the development of various immune cells, including CD4 T cells and natural killer (NK) cells.
- It is implicated in T cell exhaustion during tumors and chronic viral infections by influencing transcriptional and epigenetic changes associated with exhausted T cells.
- Additionally, TOX is involved in maintaining antigen-specific T cell persistence and enhances PD-1 levels on T cells, providing insights for potential therapies targeting chronic infections and cancer.