miR-130b participates in wear particle-induced inflammation and osteolysis via FOXF2/NF-κB pathway.

Objective: To reveal other miR-130b-mediated signaling pathway in the involvement of wear particle-induced inflammation and osteolysis.

Materials And Methods: Particle-induced osteolysis (PIO) mice model was established. Secretion levels of TNF-α, IL-1β, IL-6, and IL-10 were measured by ELISA.

LncRNA TSIX promotes osteoblast apoptosis in particle-induced osteolysis by down-regulating miR-30a-5p.

Objective: This study aims to investigate the role of TSIX/miR-30a-5p axis in particle-induced osteolysis (PIO).

Method: PIO mouse model was established by the implantation of Co-Cr-Mo metal particles (CoPs). MC3T3-E1 cells received CoPs stimulation.

MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).

Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria.

MicroRNA MiR-130b promotes wear particle-induced osteolysis via down regulating frizzled-related protein (FRZB).

Periprosthetic osteolysis induced by wear particles can lead to aseptic loosening, one main reason of arthroplasty failure. However, the role of microRNA-130b (miR-130b) in particle-induced osteolysis (PIO) has not been explored yet. In this study, PIO models were established in C57BL/J6 mice via the implantation of Co-Cr-Mo alloy particles, and evaluated by detecting tartrate-resistant acid phosphatase (TRAP) activity and bone resorption in the calvaria.

Abrasive Endoprosthetic Wear Particles Inhibit IFN-γ Secretion in Human Monocytes Via Upregulating TNF-α-Induced miR-29b.

The adverse biological responses to prostheses wear particles commonly led to the failure of total hip arthroplasty. Among the released cytokines, interferon-γ (IFN-γ) has been found to be a critical functional factor during osteoclast differentiation. However, the molecular mechanism underlying the regulation of IFN-γ in wear particles-induced cells still needs to be determined.

[Clinical research of posterior cruciate ligament-retained mobile-bearing total knee arthroplasty in treatment of rheumatoid arthritis].

Objective: To analyse the results of posterior cruciate ligament-retained mobile-bearing total knee arthroplasty (TKA) in treatment of rheumatoid arthritis (RA) and to solve the problems often encountered during surgery.

Methods: From February 1999 to August 2005, the clinical data from 73 patients with RA undergoing TKA were analysed retrospectively. In 73 patients, 38 patients were treated with posterior cruciate ligament-retained mobile-bearing prosthesis (group A), while 35 patients were treated with posterior stabilized fixed-bearing prosthesis (group B).

[Application of all-coated long stem prosthesis associated with allograft in revision total hip arthroplasty].

Objective: To study the effect of all-coated long stem prosthesis associated with allograft in revision total hip replacement (THR).

Methods: From January 1997 to January 2004, 20 patients with non-infectious loosened implant after primary THR were treated. There were 12 males and 8 females with a mean age of 65 years (58-77 years).