E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.

The carboxyl terminus of Hsc70-interacting protein (CHIP) is pivotal for managing misfolded and aggregated proteins via chaperone networks and degradation pathways. In a preclinical rodent model of CHIP-related ataxia, we observed that CHIP mutations lead to increased levels of phosphodiesterase 9A (PDE9A), whose role in this context remains poorly understood. Here, we investigated the molecular mechanisms underlying the role of PDE9A in CHIP-related ataxia and demonstrated that CHIP binds to PDE9A, facilitating its polyubiquitination and autophagic degradation.

Xinnaotongluo liquid protects H9c2 cells against hypoxic damage through IRF2/HIF-1α-mediated oxidation, inflammation, and apoptosis.

Myocardial ischemia is the primary reason for ischemic heart disease. Xinnaotongluo liquid has been reported to have an improving effect on cardiovascular diseases. In our study, we detected the effects of Xinnaotongluo liquid on H9c2 cell oxidation, inflammation, and apoptosis induced by hypoxia stimulation.

Silencing of TXNIP attenuates oxidative stress injury in HEI-OC1 by inhibiting the activation of NLRP3 and NF-κB.

Sensorineural hearing loss (SNHL) is the most common type of hearing loss worldwide. The primary mechanism is oxidative injury to the cochlea as a result of oxidative stress. Therefore, exploring antioxidant strategies is particularly important in addressing SNHL.

Serum lipid metabolism characteristics and potential biomarkers in patients with unilateral sudden sensorineural hearing loss.

Background: Glycerophospholipids (GPLs) are essential for cell membrane structure and function. Sphingomyelin and its metabolites regulate cell growth, apoptosis, and stress responses. This study aimed to investigate lipid metabolism in patients experiencing sudden sensorineural hearing loss across all frequencies (AF-SSNHL).

Serum Prealbumin as a Potential Predictive Factor for Age-Related Hearing Loss: A Retrospective Study.

Age-related hearing loss (ARHL) is a complex disease associated with the interaction of multiple factors. Furthermore, indicators of liver function represent the body's metabolic, immune, and repair abilities. This study investigated correlations between liver function and ARHL.

Ultrathin BiOCl-OV/CoAl-LDH S-scheme heterojunction for efficient photocatalytic peroxymonosulfate activation to boost Co =O generation.

Sustainable and rapid production of high-valent cobalt-oxo (Co(IV)=O) species for efficiently removing organic pollutants is challenging in permoxymonosulfate (PMS) based advanced-oxidation-processes (AOPs) due to the limitation of the high 3d-orbital electronic occupancy of Co and slow conversion from Co(III) to Co(II). Herein, S-scheme BiOCl-OV/CoAl-LDH heterojunction were constructed by ultrathin BiOCl with the oxygen-vacancy (OV) self-assembled with ultrathin CoAl-LDH. OV promoted the formation of charge transfer channel (Bi-O-Co bonds) at the interface of the heterojunction and reduced electron occupation of the Co 3d-orbital to facilitate the generation of Co(IV)=O in the BiOCl-OV/CoAl-LDH/PMS/Visible-light system.

Traditional and non-traditional lipid parameters as risk factors for sudden sensorineural hearing loss.

Objective: The purpose was to explore the effects of traditional and non-traditional lipid parameters on Sudden Sensorineural Hearing Loss (SSNHL).

Methods: The study included 452 patients diagnosed with SSNHL, among whom 206 patients had a level of hearing improvement ≥10 dB after one month of follow-up. A propensity score-matched (2:1) control group was used.

Simultaneous detection of heterocyclic aromatic amines and acrylamide in thermally processed foods by magnetic solid-phase extraction combined with HPLC-MS/MS based on cysteine-functionalized covalent organic frameworks.

Acrylamide (AA) and heterocyclic aromatic amines (HAAs), as classic hazards produced during food thermal processing, have been widely concerned, but because of their polarity difference, it is very difficult to detect these contaminants simultaneously. Herein, novel cysteine (Cys)-functionalized magnetic covalent organic frameworks (FeO@COF@Cys) were synthesized via a thiol-ene click strategy and then used as adsorbents for magnetic solid-phase extraction (MSPE). Benefiting from the hydrophobic properties of COFs and the modification of hydrophilic Cys, AA and HAAs could be enriched simultaneously.

In Situ Synthesis of BiMoO/BiSiO Heterojunction for Efficient Degrading of Persistent Pollutants.

Photocatalytic degradation is an environmentally friendly way to eliminate environmental pollution. Exploring a photocatalyst with high efficiency is essential. In the present study, we fabricated a BiMoO/BiSiO heterojunction (BMOS) with intimate interfaces via a facile in situ synthesis method.

Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study.

Introduction: There is a high incidence of both smoking and tuberculosis (TB) in China. This study examined the risk factors for severe pulmonary TB (PTB) and positive tubercle bacilli in sputum.

Methods: We conducted a retrospective case-control study in a tertiary hospital from January 2017 to December 2018 ( = 917).

A Lead-Free 0D/2D CsBiBr/BiWO S-Scheme Heterojunction for Efficient Photoreduction of CO.

Photocatalytic reduction of CO into valuable hydrocarbon fuels is one of the green ways to solve the energy problem and achieve carbon neutrality. Exploring photocatalyst with low toxicity and high-efficiency is the key to realize it. Here we report a lead-free halide perovskite-based 0D/2D CsBiBr/BiWO (CBB/BWO) S-scheme heterojunction for CO photoreduction, prepared by a facile electrostatic self-assembly approach.

Case report: Successful management of pneumonia mimicking hematogenous pneumonia.

is an anaerobic Gram-positive coccus frequently found in the oral cavity and gastrointestinal tract, but rarely in the lung. Therefore, pneumonia caused by is also rare. Although there are some reports of related pneumonia due to aspiration or blood-borne infection with definite remote infection source, there are no reported cases of hematogenous pneumonia in healthy adults lacking a remote source of infection.

HMGB1 accumulation in cytoplasm mediates noise-induced cochlear damage.

Damage-associated molecular pattern molecules (DAMPs) play a critical role in mediating cochlear cell death, which leads to noise-induced hearing loss (NIHL). High-mobility group box 1 (HMGB1), a prototypical DAMP released from cells, has been extensively studied in the context of various diseases. However, whether extracellular HMGB1 contributes to cochlear pathogenesis in NIHL and the potential signals initiating HMGB1 release from cochlear cells are not well understood.

Effect of Combining Sound Therapy with Pharmacotherapy on the Recovery of Hearing Abilities in the Case of Sudden Sensorineural Hearing Loss: A Prospective Study.

Introduction: This study investigated the effect of sound therapy combined with drug therapy (SDT) on gap detection threshold and speech recognition scores in patients with sudden sensorineural hearing loss (SSNHL).

Methods: Patients with SSNHL were grouped randomly into SDT and drug therapy (DT) groups. All patients received standard drug treatment and patients in the SDT group additionally received sound stimulation for the affected ears for 6 days.

Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study.

Objectives: This study aims to explore the relationship between bone-turnover biomarkers and the recovery of SSNHL to provide clues for further improvements in etiological research and predictors.

Methods: The medical history, hearing thresholds, biomarkers of bone-turnover, and related hormones of 117 SSNHL patients were collected prospectively between August 2018 and December 2021. Linear correlation and logistic regression models were applied to examine the association between bone-turnover biomarkers and the prognosis of SSNHL.

Heterocyclic aromatic amines induce Neuro-2a cells cytotoxicity through oxidative stress-mediated mitochondria-dependent apoptotic signals.

Heterocyclic aromatic amines (HAAs) are a class of hazardous compounds produced in food thermal processing. These compounds raise concerns because they have mutagenic and carcinogenic properties. However, the neurotoxicity of these compounds has received limited attention.

Differential weighting of temporal envelope cues from the low-frequency region for Mandarin sentence recognition in noise.

Background: Temporal envelope cues are conveyed by cochlear implants (CIs) to hearing loss patients to restore hearing. Although CIs could enable users to communicate in clear listening environments, noisy environments still pose a problem. To improve speech-processing strategies used in Chinese CIs, we explored the relative contributions made by the temporal envelope in various frequency regions, as relevant to Mandarin sentence recognition in noise.

Bottom-Up and Top-Down Attention Impairment Induced by Long-Term Exposure to Noise in the Absence of Threshold Shifts.

Objective: We aimed to assess the effect of noise exposure on bottom-up and top-down attention functions in industrial workers based on behavioral and brain responses recorded by the multichannel electroencephalogram (EEG).

Method: In this cross-sectional study, 563 shipyard noise-exposed workers with clinical normal hearing were recruited for cognitive testing. Personal cumulative noise exposure (CNE) was calculated with the long-term equivalent noise level and employment duration.