A hierarchical cobalt/carbon nanotube hybrid nanocomplex-based ratiometric fluorescent nanosensor for ultrasensitive detection of hydrogen peroxide and glucose in human serum.

Highly sensitive detection of HO and glucose is critical for fundamental research and disease diagnosis. A ratiometric sensor can simultaneously afford two readout signals that provide an internally normalized response to change, thereby reducing false results and improving detection accuracy. A novel ratiometric fluorescent nanosensor for ultrasensitive detection of hydrogen peroxide and glucose was constructed on the basis of the peroxidase-like properties of a hierarchical cobalt/carbon nanotube hybrid nanocomplex (Co-CNT).

A MnO nanosheet-based ratiometric fluorescent nanosensor with single excitation for rapid and specific detection of ascorbic acid.

Ascorbic acid (AA) detection in biological sample and food sample is critical for human health. Herein, a MnO nanosheet (MnO-NS)-based ratiometric fluorescent nanosensor has been developed for high sensitive and specific detection of AA. The MnO-NS presents peroxidase-like activity and can oxidize non-fluorescent substrate of o-phenylenediamine (OPDA) into fluorescent substrate, presenting maximum fluorescence at 568 nm (F).

Multiple advanced logic gates made of DNA-Ag nanocluster and the application for intelligent detection of pathogenic bacterial genes.

The integration of multiple DNA logic gates on a universal platform to implement advance logic functions is a critical challenge for DNA computing. Herein, a straightforward and powerful strategy in which a guanine-rich DNA sequence lighting up a silver nanocluster and fluorophore was developed to construct a library of logic gates on a simple DNA-templated silver nanoclusters (DNA-AgNCs) platform. This library included basic logic gates, YES, AND, OR, INHIBIT, and XOR, which were further integrated into complex logic circuits to implement diverse advanced arithmetic/non-arithmetic functions including half-adder, half-subtractor, multiplexer, and demultiplexer.

A target-induced logically reversible logic gate for intelligent and rapid detection of pathogenic bacterial genes.

For the first time, a target (pathogenic bacterial gene)-induced logically reversible logic gate was constructed as an intelligent biosensor, which has one-to-one mapping functionality and can rapidly distinguish all information of the two targets, the presence of any target and the absence (or presence) of both of the targets, from the unique output signal pattern.