Exploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA.

Background: Submergence stress is a prevalent abiotic stress affecting plant growth and development and can restrict plant cultivation in areas prone to flooding. Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. Red clover (Trifolium pratense L.

Advancing lung adenocarcinoma prognosis and immunotherapy prediction with a multi-omics consensus machine learning approach.

Lung adenocarcinoma (LUAD) is a tumour characterized by high tumour heterogeneity. Although there are numerous prognostic and immunotherapeutic options available for LUAD, there is a dearth of precise, individualized treatment plans. We integrated mRNA, lncRNA, microRNA, methylation and mutation data from the TCGA database for LUAD.

Automatic Electrochemiluminescence Method for the Detection of Cancerous Exosomes Incorporating Specific Aptamer-Magnetic Beads and Signal Nanoprobes.

Exosomes, as an emerging biomarker, have exhibited remarkable promise in early cancer diagnosis. Here, a highly sensitive, selective, and automatic electrochemiluminescence (ECL) method for the detection of cancerous exosomes was developed. Specific aptamer-(EK) peptide-tagged magnetic beads (MBs-(EK)-aptamer) were designed as a magnetic capture probe in which the (EK) peptide was used to reduce the steric binding hindrance of cancerous exosomes with a specific aptamer.

Morphological and molecular response mechanisms of the root system of different species to submergence stress.

Introduction: The severity of flood disasters is increasing due to climate change, resulting in a significant reduction in the yield and quality of forage crops worldwide. This poses a serious threat to the development of agriculture and livestock. is an important high-quality forage grass in southern China.

Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures.

Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined.

Imaging and Simulation of Ruthenium Derivative Coating Microbeads at the Opaque Electrode with Electrogenerated Chemiluminescence.

Electrogenerated chemiluminescence (ECL) imaging is gaining increasing attention in various fields because of its high sensitivity, low background, and good temporal and spatial resolution. However, ECL imaging of microsized objects at the opaque electrode via top-view configuration is challenged with the reactants' diffusion and light propagation. Here, we imaged and numerically simulated ruthenium derivative coating polystyrene microbeads (Ru1-PS@MB) at the glassy carbon electrode (GCE) via top-view configuration by ECL imaging.

Manipulation of crystallization nucleation and thermal degradation of PLA films by multi-morphologies CNC-ZnO nanoparticles.

Currently, the quest for more renewable and biodegradable materials is a scientific priority to address the problems of petroleum-based plastics are difficult to degrade. In this work, cellulose nanocrystals (CNC) have been used as a template and four morphologies of CNC-ZnO nanocomposites were prepared via a hydrothermal method, and CNC-ZnO/polylactic acid (PLA) composite films were obtained by solution casting. We find that CNC-ZnO nanocomposites as heterogeneous nucleating agents improved the crystallinity and the film with flower-like CNC-ZnO was improved by 2.

A novel signature predicts prognosis and immunotherapy in lung adenocarcinoma based on cancer-associated fibroblasts.

Background: Extensive research has established the significant correlations between cancer-associated fibroblasts (CAFs) and various stages of cancer development, including initiation, angiogenesis, progression, and resistance to therapy. In this study, we aimed to investigate the characteristics of CAFs in lung adenocarcinoma (LUAD) and develop a risk signature to predict the prognosis of patients with LUAD.

Methods: We obtained single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data from the public database.

A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer.

Background: Current paradigms of anti-tumor therapies are not qualified to evacuate the malignancy ascribing to cancer stroma's functions in accelerating tumor relapse and therapeutic resistance. Cancer-associated fibroblasts (CAFs) has been identified significantly correlated with tumor progression and therapy resistance. Thus, we aimed to probe into the CAFs characteristics in esophageal squamous cancer (ESCC) and construct a risk signature based on CAFs to predict the prognosis of ESCC patients.

Tracking the Dissolution Surface Kinetics of a Single Fluorescent Cyclodextrin Metal-Organic Framework by Confocal Laser Scanning Microscopy.

The understanding of the dissolution processes of solids is important for the design and synthesis of solids in a controlled and precise manner and for predicting their fate in the aquatic environment. We report herein single-particle-based confocal laser scanning microscopy (CLSM) for tracking the dissolution surface kinetics of a single fluorescent cyclodextrin metal-organic framework (CD-MOF). As a proof of concept, CD-MOF containing fluorescein, named as CD-MOF⊃FL, was synthesized by encapsulating fluorescein into the interior of CD-MOF via a vapor diffusion method and used as a single-particle dissolution model because of its high FL efficiency and unique structure.

By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is a heterogeneous disease with a dismal prognosis for advanced tumors. Immune-associated cells in the microenvironment substantially impact LUAD formation and progression, which has gained increased attention in recent decades. Sphingolipids have a profound impact on tumor formation and immune infiltration.

Cuproptosis-related lncRNA signatures: Predicting prognosis and evaluating the tumor immune microenvironment in lung adenocarcinoma.

Background: Cuproptosis, a unique kind of cell death, has implications for cancer therapy, particularly lung adenocarcinoma (LUAD). Long non-coding RNAs (lncRNAs) have been demonstrated to influence cancer cell activity by binding to a wide variety of targets, including DNA, RNA, and proteins.

Methods: Cuproptosis-related lncRNAs (CRlncRNAs) were utilized to build a risk model that classified patients into high-and low-risk groups.

Study on the interaction of L. centrin and melittin.

L. centrin (Zmcen) is a 20 kDa calcium binding protein also known as caltractin. We used melittin as a simulated target peptide and examined its interaction with Zmcen to understand the structure of Zmcen and the mechanism of interaction with downstream target peptides.

Adsorption of dye from wastewater using chitosan-CTAB modified bentonites.

Dyeing wastewater removal is important for the water treatment, and adsorption is an efficient treatment process. In this study, three modified bentonites, chitosan modified bentonite (CTS-Bent), hexadecyl trimethyl ammonium bromide (CTAB) modified bentonite (CTAB-Bent), and both chitosan and hexadecyl trimethyl ammonium bromide modified bentonite (CTS-CTAB-Bent) were prepared and characterized by FTIR and XRD analysis. Batch experiments were conducted to evaluate the adsorptive removal of weak acid scarlet from aqueous phase using modified bentonites under different conditions.