Publications by authors named "Yanling Wang"

Objective: The study aims to determine the correlation between cerebral small vessel diseases (SVDs) and nonarteritic anterior ischemic optic neuropathy (NAION). Additionally, investigate whether NAION raises the risk of an increased total cerebral small vessel disease score (CSVD score) compared to control group without ocular conditions.

Methods: 101 controls without any retinal illness and 61 individuals with NAION were enrolled for this retrospective case control study.

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Tartary buckwheat, a protein-rich pseudocereal with anti-diabetic effects, has not yet been fully explored as a source of dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides. This study aims to discover novel DPP-IV inhibitory peptides from tartary buckwheat protein (TBP). Five hydrolysis methods were employed, with simulated gastrointestinal digestion (SGID) releasing the most active DPP-IV inhibitory hydrolysates, showing both the highest degree of hydrolysis (22.

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Diversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, suggesting they play adaptive roles in this environment. We identified >1,100 unique DGRs among human-associated species and discovered a subset that diversify adhesive components of Type V pili and related proteins.

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PTD-FNK, a synthetic anti-apoptotic protein, has been shown to potently alleviate cellular injuries. However, the effects of PTD-FNK on oxidative defense in boar testicular Sertoli cells (SCs) against oxidative injury has not been explored. In this study, we show that exposure of SCs to 100 mg/L lipopolysaccharide (LPS) for 12 h leads to decreased survival rate, superoxide dismutase (SOD) activity, and increased malondialdehyde (MDA).

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Developmental plasticity is critical for plants to adapt to constantly changing environments. Plant root hairs display dramatic plasticity under different environments and therefore play crucial roles in defense against environmental stressors. Here, we report the isolation of an Arabidopsis mutant, salinity over-sensitive mutant 1-1 (som1-1), also exhibiting root hair developmental defects.

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Article Synopsis
  • The study aimed to compare the safety and efficacy of trial lens-fitting versus software-fitting in orthokeratology for myopia control in children with a high corneal eccentric value.
  • A total of 89 myopic children participated, split into two groups, with various ocular measurements taken over 12 months to assess treatment outcomes.
  • Both methods were found to be effective and safe, but the software-fitting resulted in a smaller treatment zone and less decentration compared to the trial lens-fitting method.
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Background: Recent studies offer conflicting conclusions about the effectiveness of digital health interventions in changing physical activity behaviors. In addition, research focusing on digital health interventions for college students remains relatively scarce.

Objective: This study aims to examine the impact of digital health interventions on physical activity behaviors among college students, using objective measures as outcome indicators.

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Long non-coding RNAs (lncRNAs) are highly versatile in their modes of action and play critical roles in both normal physiological and disease processes. The dysregulation of lncRNA expression has been implicated in aging and many neurological disorders, including Alzheimer's disease (AD). Here, we report a spatial expression atlas of 7,634 lncRNA genes in aged human brains, covering 258,987 microdomains from 78 postmortem brain sections of 21 ROSMAP participants.

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  • The all-dielectric metasurface shows promise as an innovative platform for creating effective optical sensors, particularly utilizing Fano resonances.
  • A specific sensor design using a hollow herringbone metasurface demonstrates high sensitivity for both temperature and refractive index measurements, with impressive simulation results indicating a Q factor of 2.6 × 10 and a sensitivity of 232 nm/RIU.
  • Experimental results confirm these findings, yielding a Q factor of 5366 and a sensitivity of 178 nm/RIU, which enhances the potential use of these sensors in biochemical analysis and environmental monitoring.
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In tomato, sugar content is highly correlated with consumer preferences, with most consumers preferring sweeter fruit. However, the sugar content of commercial varieties is generally low, as it is inversely correlated with fruit size, and growers prioritize yield over flavour quality. Here we identified two genes, tomato (Solanum lycopersicum) calcium-dependent protein kinase 27 (SlCDPK27; also known as SlCPK27) and its paralogue SlCDPK26, that control fruit sugar content.

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The gene signatures of Alzheimer's Disease (AD) brains reflect an output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulations. To identify the most significant factor that shapes the AD brain signature, we developed a machine learning model (DEcode-tree) to integrate cellular and molecular factors explaining differential gene expression in AD. Our model indicates that YTHDF proteins, the canonical readers of N6-methyladenosine RNA modification (m6A), are the most influential predictors of the AD brain signature.

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Aims/background: Liver transplantation specialist nurses provide comprehensive and safe care for liver transplant patients, which requires them to have a wide range of competencies. However, at present, there is no comprehensive understanding of the competency of liver transplantation specialist nurses in China, and there is a lack of comprehensive evaluation indicators. The purpose of this study was to construct a competency evaluation indicator system for specialist nurses in liver transplantation.

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Lignin is one of the main components in plants, which can transform value-added bioenergy and chemicals. At the same time, due to the close combination of lignin and hemicellulose in the structure, it becomes a barrier for cellulose utilization. Therefore, the effective degradation of lignin is of great significance for the utilization of these resources.

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Objectives: Adipose tissue depots vary markedly in their ability to store and metabolize triglycerides, undergo beige adipogenesis and susceptibility to metabolic disease. The molecular mechanisms that underlie such heterogeneity are not entirely clear. Previously, we showed that TGF-β signaling suppresses beige adipogenesis via repressing the recruitment of dedicated beige progenitors.

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Article Synopsis
  • The study investigates Chinese undergraduate nursing students' perceptions and experiences of digital learning, aiming to enhance future digital teaching methods in higher education.
  • Conducted across six universities in three cities, the research involved semi-structured online interviews with 26 nursing students who had experience with digital learning.
  • Findings revealed three main themes: positive experiences with access to diverse resources, negative feelings of isolation during online learning, and various barriers affecting students' engagement with digital platforms.
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  • The study focuses on the role of SPI in the development of trichomes, specialized epidermal cells in plants, highlighting its influence on cytoskeleton organization and cell shape.
  • Researchers found that SPI affects microtubule stability during trichome branching; loss of SPI leads to abnormalities in trichome structures and sensitivity to microtubule-disrupting drugs.
  • The interaction between SPI and another protein, ZWI, shows that they work together to regulate microtubule dynamics, further influencing trichome morphology and overall plant cell shape development.
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  • This study investigates the increasing rates of brucellosis among children in Inner Mongolia from 2016 to 2020, focusing on its spatial and temporal distribution.
  • Using Bayesian and geographical weighted regression models, it identifies Hinggan as the area with the highest incidence rates, while Alxa shows a rapidly rising risk.
  • The study concludes that factors such as sheep population, average temperature, and precipitation significantly contribute to the incidence of brucellosis in children, highlighting the need for protective measures in vulnerable areas.
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  • The study examined how different steaming durations (0, 4, 8, and 12 hours) affect the structure and characteristics of polysaccharides (PCPs), particularly regarding digestion, absorption, and gut microbiota fermentation.
  • Chemical analysis revealed that longer steaming reduced carbohydrate content while increasing certain components like uronic acid and protein in the PCPs.
  • Results showed that while all PCPs were resistant to saliva digestion, they improved gastrointestinal digestibility and altered gut microbiota composition, leading to increased short-chain fatty acid production, though this declined with longer steaming times.
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  • A study examined the interaction between amyloid-beta (Aβ) plaques and glial cells in Alzheimer's Disease using spatial transcriptomics and immunohistochemistry on postmortem brain samples.
  • Findings revealed that low Aβ areas show higher neuronal loss, while high-glia areas indicate increased inflammation and neurodegeneration, with various glial states surrounding plaques.
  • The results suggest that the microglial response to Aβ may trigger glial activation, paving the way for future research into the complex pathology of neurodegenerative diseases.
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Sonodynamic therapy (SDT) can generate reactive oxygen species (ROS) to combat multidrug-resistant biofilms, which pose significant challenges to human health. As the key to producing ROS in SDT, the design of sonosensitizers with optimal molecular structures for sufficient ROS generation and activity in complex biofilm matrix is essential. In this study, we propose a π-expansion strategy and synthesize a series of small-molecule metal Ru(II) complexes (-) as sonosensitizers (-) to enhance the efficacy of SDT.

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  • * Free fatty acids (FFAs) increase in response to the decline in phospholipids and exhibit an opposite trend in their levels, indicating a relationship between the two.
  • * The study suggests severe neuron damage due to KA treatment is linked to increased cell membrane permeability and abnormalities in the endomembrane system, which may contribute to FFA release.
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Neutrophil elastase (NE) is a protease released by activated neutrophils in the brain parenchyma after cerebral ischemia, which plays a pivotal role in the regulation of neutrophil extracellular traps (NETs) formation. The excess NETs could lead to blood-brain barrier (BBB) breakdown, overwhelming neuroinflammation, and neuronal injury. While the potential of targeting neutrophils and inhibiting NE activity to mitigate ischemic stroke (IS) pathology has been recognized, effective strategies that inhibit NETs formation remain under-explored.

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Subretinal injection (SR injection) is a commonly used method of ocular drug delivery and has been mainly applied for the treatment of neovascular age-associated macular degeneration (nAMD) and sub-macular hemorrhage (SMH) caused by nAMD, as well as various types of hereditary retinopathies (IRD) such as Stargardt's disease (STGD), retinitis pigmentosa (RP), and a series of fundus diseases such as Leber's congenital dark haze (LCA), choroidal defects, etc. The commonly used carriers of SR injection are mainly divided into viral and non-viral vectors. Leber's congenital amaurosis (LCA), choroidal agenesis, and a series of other fundus diseases are also commonly treated using SR injection.

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