Publications by authors named "Yanling Nie"
Article Synopsis
- Targeted reprogramming of cancer-associated fibroblasts (CAFs) is crucial for effective cancer therapy, but there are significant challenges in deactivating active CAFs.
- A new compound, PDIC-OC, has been developed that induces a burst of reactive oxygen species (ROS), leading to cell apoptosis and reduced TGF-β production in CAFs.
- PDIC-OC effectively reprograms CAFs, promotes the transformation of M2-type macrophages to M1-type, improves T cell infiltration, and demonstrates strong anti-tumor effects in mouse models, making it a promising strategy for treating hypoxic tumors.
Background: Nonylphenol (NP) is a common environmental endocrine disruptor that is associated with the development of cardiovascular disease. However, the toxic effect of NP on mitochondria in the heart of offspring to exposed individuals remains exclusive.
Objective: To investigate whether perinatal NP exposure causes mitochondrial damage in the hearts of offspring of exposed individuals and determine its mechanism of action through both animal and cell experiments.