Publications by authors named "Yanling Ma"

This study constructed a prognostic model combining machine learning-based immune infiltration-related genes in each CRC subtype. We used publicly accessible gene expression data and clinical information on colorectal cancer patients. Integrated bioinformatics analysis was used for the identification of immune-wise genes.

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Objective: To systemically assess efficacy and safety of upadacitinib (UPA), a selective inhibitor of Janus kinase 1 (JAK1) in treatment of ankylosing spondylitis (AS).

Methods: Available databases were used to retrieve literatures of randomized controlled trials (RCTs) of UPA for AS treatment until February 2024. After that, the data were extracted and the Revman 5.

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Objective: To evaluate the diagnostic performance and clinical impact of targeted next-generation sequencing (tNGS) in patients with suspected lower respiratory tract infections.

Methods: Following propensity score matching, we compared the diagnostic performances of tNGS and metagenomic next-generation sequencing (mNGS). Furthermore, the diagnostic performance of tNGS was compared with that of culture, and its clinical impact was assessed.

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In this study, by analyzing the available near full-length genome (NFLG) sequences of CRF55_01B, it was found that two of the NFLG sequences could not be clustered with other NFLG sequences. Recombination analysis and phylogenetic analysis suggested that these two NFLG sequences arose by recombination with subtype B based on CRF55_01B, rather than by recombination directly derived from CRF01_AE and subtype B. In addition, two other HIV-1 partial gene fragments found in the database shared the same characteristics as these two NFLG sequences in the key recombination region.

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To address the need for highly sensitive and reliable detection of trace ochratoxin A (OTA) in food matrices, we developed a ratiometric fluorescent aptasensor by integrating CRISPR/Cas12a, hybridization chain reaction (HCR), and horseradish peroxidase (HRP)-induced inner filter effect (IFE). The mechanism involves OTA releasing an activator that initiates CRISPR/Cas12a trans-cleavage, blocking HCR assembly. This reduces HRP levels, limiting the conversion of o-phenylenediamine (OPD) to fluorescent 2,3-diaminophenazine (DAP) (emitting at 562 nm) while maintaining strong emission from 2-amino terephthalic acid (BDC-NH) at 426 nm.

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is a major producer of ochratoxin A (OTA), a highly toxic and carcinogenic mycotoxin found in various food and feed products. produces excessive amount of OTA under various water activity (a) conditions that occur during food and feed storage. The biosynthetic gene clusters associated with OTA production include , which plays a key role in controlling mycotoxin production in response to environmental conditions.

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Purpose: The extracellular matrix (ECM) plays a pivotal role in the initiation and progression of hepatocellular carcinoma (HCC) by facilitating the proliferation of HCC cells and enabling resistance to Anoikis. ECM also provide structural support that aids in the invasion of HCC cells, thereby influencing the tumor microenvironment. Due to genetic variations and molecular heterogeneity, significant challenges exist in the treatment of HCC, particularly with immunotherapy, which frequently leads to immune tolerance and suboptimal immune responses.

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Urease containing nickel cofactor is crucial for urea-hydrolytic induced calcium carbonate (CaCO) precipitation (UICP). However, limited information exists regarding the influence of amino acid residues interacting with nickel ions in its structure on induced CaCO mineralization. Herein, RT-qPCR was used to demonstrate that the addition of NiCl dramatically upregulated the expression of urease structural gene that was correlated with nickel binding in strain NS-6.

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We present a portable single-shot lens-free tomographic microscope, based on spatial multiplexing in-line digital holography, for three-dimensional (3D) imaging of dynamic specimens. The simplified system is realized by only a laser diodes array, a rectangular aperture, and a CMOS image sensor with a global shutter, which enables the recording of all the complex fields of a dynamic specimen from different illumination angles without any scanning mechanism by a multiplexing hologram, in a single camera exposure. Using our proposed data processing method, high-quality 3D tomograms, with a lateral resolution of 3.

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  • Depression is a major mental health risk for older adults, and self-employment has become a key alternative for them as the population ages and retirement is delayed.
  • Research using data from the China Health and Retirement Longitudinal Study shows that self-employed older adults experience lower levels of depression compared to retirees, with social participation and life satisfaction acting as mediating factors.
  • The study highlights urban-rural disparities and differences in self-employment types affecting these depression levels, offering valuable insights for improving mental health and informing aging policies in China and similar countries.
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  • Shape-controlled alloy nanoparticle catalysts improve performance in oxygen reduction reactions (ORR) in liquid half-cells, but face challenges in fuel cell applications due to harsher operating conditions.* -
  • A new strategy was developed to limit atomic diffusion in surface layers, allowing for the selective transformation of platinum-iron nanowires into stable intermetallic structures at low temperatures.* -
  • This surface engineering approach enhances membrane electrode assembly (MEA) stability by reducing iron loss by 50% while maintaining high catalytic activity, showing promise for practical fuel cell applications with shape-controlled catalysts.*
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  • The NSP14 protein of SARS-CoV-2 aids viral replication and boosts the host's immune system by enhancing the production of cytokines.
  • The study reveals that NSP14 activates the AP-1 pathway by increasing the phosphorylation of ERK, which then promotes AP-1 transcription.
  • NSP14 interacts with MEK, leading to increased levels of phosphorylated MEK, and the use of a MEK inhibitor partially blocks cytokine production, indicating a novel mechanism for NSP14's proinflammatory response.
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  • Urease in microorganisms is crucial for calcite precipitation, but there's limited genomic data on urease-producing strains, highlighting a need for deeper research into its activity regulation by nickel ligands.
  • The study focused on a newly isolated strain YX-3, revealing the presence of urease gene clusters and demonstrating that nickel ions significantly enhance the expression of the ureC gene.
  • Mutations in specific residues (His267, His294, Gly325) were shown to decrease urease activity and calcium carbonate precipitation, indicating their essential role in urease functionality and providing insights for future research on urease regulation.
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  • * A study identified four HIV-1 samples potentially forming a new circulating recombinant form (CRF150_cpx) based on genetic analysis, revealing connections to the existing CRF149_01B and CRF07_BC genotypes.
  • * The discovery of new CRFs enhances our knowledge of HIV recombination and helps track its prevalence and transmission within specific populations.
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  • * What is added: A recent randomized controlled trial indicates that better follow-up and counseling can improve adherence to ART, which enhances the overall effectiveness of the treatment.
  • * Implications for public health: It is important to provide early testing and counseling for serodiscordant couples after identifying an HIV-positive partner to initiate ART and lower the risk of HIV transmission to the uninfected partner; combining ART with counseling is recommended.
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  • The study aimed to explore the relationship between early growth response factor 3 (Egr3) and various inflammatory and growth-related molecules in patients with coronary artery disease (CAD).
  • Researchers compared Egr3 and other markers in 132 CAD patients and 63 healthy controls, finding higher levels of Egr3, IL-6, and IL-1β in patients with severe stenosis compared to those with mild stenosis and controls.
  • In vitro experiments demonstrated that reducing Egr3 levels decreased other inflammatory markers and lipid droplet formation, suggesting Egr3 could play a significant role in CAD progression.
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  • The border areas of Yunnan Province, China, are facing significant HIV challenges, prompting a study that involved collecting blood samples to investigate transmission risks and the extent of pretreatment drug resistance (PDR) among newly reported cases in 2021.
  • Among 174 genotyped samples, various HIV genotypes were identified, with CRF08_BC being the most prevalent, and specific populations (Chinese, Burmese, men who have sex with men) exhibited distinct genetic characteristics.
  • The study found a notable prevalence of PDR to antiretroviral drugs, particularly NNRTIs, indicating rising resistance trends, and highlighted the importance of localized interventions for effective AIDS prevention strategies.
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  • * Researchers explored a new subunit vaccine (Ag85B:c-di-AMP) delivered intranasally in mice with a persistent TB infection, which improved immune responses compared to the standard Ag85B vaccine.
  • * The study found that the new vaccine reduced lung damage and M. tuberculosis levels while enhancing immune cell activity, suggesting that c-di-AMP could be a promising adjuvant for future TB vaccines.
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  • High-entropy alloys (HEAs) are gaining interest as effective catalysts for oxygen reduction reactions, especially in utilizing platinum (Pt) due to their unique properties.
  • A new method for creating high-entropy nanoparticles involves thermal reduction using metal-organic frameworks (MOFs), resulting in catalysts that significantly outperform traditional Pt/C catalysts in terms of mass activity.
  • The process of electrochemical activation leads to structural changes in the catalysts, creating defects and single atoms that enhance their performance, suggesting valuable implications for fuel cell technology.
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The optimal design of groundwater circulation wells (GCWs) is challenging. The key to purifying groundwater using this technique is its proficiency and productivity. However, traditional numerical simulation methods are limited by long modeling times, random optimization schemes, and optimization results that are not comprehensive.

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  • The study aimed to understand how sevoflurane anesthesia impacts the development of the nervous system in offspring through the GABAAR/Sirt-1 pathway.
  • Pregnant rats were exposed to different durations of sevoflurane or treated with a Sirt-1 activator, and assessments were made on their offspring's learning, memory, and neuronal health in the brain.
  • Results showed that longer sevoflurane exposure led to neuronal damage and impaired learning, but the Sirt-1 activator showed improvements in neuronal structure and function.
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  • Salt tolerance in rice seed germination is crucial for successful planting, especially under conditions of salinity, but the genetic regulation behind it is not fully understood.
  • This study utilized genome-wide association studies (GWAS) on 541 global rice varieties to identify the genetic factors affecting seed germination under salt stress.
  • Three key quantitative trait loci (QTLs) related to salt tolerance were found, and a specific gene associated with enhanced salt stress response was highlighted, suggesting pathways to improve rice cultivation in saline environments.
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