A Soft Patch for Dynamic Myocardial Infarction Monitoring.

Wearable electronics for cardiac monitoring have been widely developed in the field of routine vital sign monitoring and arrhythmia determination due to their convenience and continuity. However, there are very few reports on the demonstration of a stretchable multilead electrocardiogram (ECG) patch integrated with myocardial infarction (MI) location capability. Here, we first propose a wearable dynamic cardiac monitoring patch, which can acquire seven-lead ECG signals continuously.

Effect of LRRC15 on autophagy in A549 cells.

Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic, and irreversible interstitial lung disease with unknown cause. To explore the role and regulatory mechanism of leucine-rich repeat-containing protein 15 (LRRC15) in IPF, bleomycin (BLM)-induced pulmonary fibrosis in mouse and A549 cells were constructed, and the expression of LRRC15 were detected. Then, MTT, GFP-RFP-LC3 dual fluorescent labeling system and Western blotting were used to investigate the effects of LRRC15 on cell activity and autophagy after transfection of siLRRC15, respectively.

A direct one-step synthesis of a smart graphene/silica nanocomposite and its application for improving the acid resistance and corrosion resistance properties of waterborne epoxy coatings.

Graphene has attracted tremendous attention as a potential building block of modern high performance coating systems. Herein, we demonstrate a green method for making reduced oxide graphene (rGO) using the natural product rutin as the reducing agent. The rGO, with residual rutin on the surface to provide surface affinity, is used in the one-step fabrication of a nanocomposite of rGO and silica nanoparticles (SN) with a corrosion inhibitor, benzotriazole (BTA), loaded .

Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, the underlying mechanism of the disease remains elusive.

Methods: To evaluate the role of Tuftelin1 (TUFT1) in IPF and elucidate its molecular mechanism. We investigated the level of TUFT1 in the IPF and bleomycin-induced mouse models and explored the influence of TUFT1 deficiency on pulmonary fibrosis.