Publications by authors named "Yanlin You"
Stimulator of interferon genes (STING) is a key connector protein in interferon (IFN) signaling, crucial for IFN induction during the activation of antiviral innate immunity. In mammals, ring finger protein 5 (RNF5) functions as an E3 ubiquitin ligase, mediating STING regulation through K150 ubiquitylation to prevent excessive IFN production. However, the mechanisms underlying RNF5's regulation of STING in teleost fish remain unknown.
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- Ranaviruses infect a variety of species including fish, amphibians, and reptiles, causing serious economic and ecological issues, with occurrences in at least 175 species worldwide.
- The study focuses on the mandarin fish ranavirus (MRV), finding a methylation level of 16.04% in its genome, which is suggested to be crucial for viral replication.
- Additionally, the research proposes that ranaviruses could have four distinct evolutionary lineages and highlights the need for a complete phylogenetic tree and further investigation into the impact of genomic methylation on viral evolution and disease control.
Background: Infectious spleen and kidney necrosis virus (ISKNV) poses a significant threat to aquaculture sustainability, particularly affecting mandarin fish () and causing significant economic losses.
Methods: To address this challenge, this study developed an ISKNV Δ vaccine strain, where the gene was knocked out. Infection assays conducted at 28 °C showed that the knocking out the gene decreased the virulence of ISKNV and reduced lethality against mandarin fish by 26.
Article Synopsis
- - Iridoviruses are large DNA viruses that infect both invertebrates and cold-blooded vertebrates, with their unique hypermethylated genomes still not fully understood.
- - The study focuses on the Infectious spleen and kidney necrosis virus (ISKNV), finding that its methylation level is 23.44%, crucial for viral replication but not for gene expression.
- - Results show that hypomethylated ISKNV boosts immune responses, indicating that increased methylation might help the virus evade the immune system, shedding light on the role of genome methylation in viral infections.
Decapod iridescent virus 1 (DIV1) is one of the major pathogens of farmed shrimp. In this study, the structural proteins of DIV1 were analyzed by mass spectrometry. DIV1 virions were purified from the hemolymph of artificially infected Cherax quadricarinatus.
View Article and Find Full Text PDFIridovirids are a group icosahedral viruses containing linear double-stranded DNA, and mainly infect invertebrates and poikilothermic vertebrates. Cherax quadricarinatus iridovirus (CQIV) is a new species of the family Iridoviridae and can cause high mortality in shrimps. In CQIV genome, there are 25 conserved genes and the putative products are involved in several viral processes.
View Article and Find Full Text PDFDrosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling. However, this activation is independent of Domeless, the sole homolog of vertebrate type I cytokine receptor.
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