Publications by authors named "Yanlin Tan"

Article Synopsis
  • - The study aimed to find the best procedure for triaging endometrial biopsies in postmenopausal women with abnormal transvaginal ultrasonography (TVU) findings and/or postmenopausal bleeding.
  • - A total of 470 women were analyzed, and the results showed that referring those with TVU abnormalities led to identifying all malignant or premalignant lesions, but with low specificity. The study identified key predictive factors such as postmenopausal bleeding, diabetes, and endometrial thickness for malignancy.
  • - A nomogram prediction model was developed that helps determine the need for an endometrial biopsy based on a score, with a clear cutoff established at 22.5; a score
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Evapotranspiration (ET) is an important process in green stormwater infrastructure (GSI) aiming to reduce urban drainage, to promote cooling and/or to contribute to an urban hydrological balance restoration closer to the natural one. However, on these structures and particularly on green roofs (GR), its evaluation remains challenging and subject to discussion. Estimates of ET by water balance, energy balance, and an ET chamber were performed on five different plots of a full-scale experimental green roof in Trappes (France).

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As the segment of diseased tissue in PET images is time-consuming, laborious and low accuracy, this work proposes an automated framework for PET image screening, denoising and diseased tissue segmentation. First, taking into account the characteristics of PET images, the framework uses a differential activation filter to select whole-body images containing lesion tissue. Second, a new neural network containing residual connections which has powerful generalization performance compared with normal FCN network is proposed for PET image reconstruction and denoising.

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Objective: Numerous circular RNAs (circRNAs) have been verified to execute crucial roles in "asthma-like" progression of the airway smooth muscle cells (ASMCs). The present study aimed to scrutinize the function and mechanism of circ_0000029 in pediatric asthma etiology .

Methods: A cell model of asthma was developed using ASMCs induced by platelet-derived growth factor BB (PDGF-BB).

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(1) Background: intervertebral disc degeneration (IVDD) defined as the degenerative changes in intervertebral disc is characterized by extracellular matrix (ECM) degradation and death in nucleus pulposus (NP) cells. (2) Methods: The model of IVDD was established in male Sprague Dawley rats using a puncture of a 21-gauge needle at the endplates located in the L4/5 intervertebral disc. Primary NP cells were stimulated by 10 ng/mL IL-1β for 24 h to mimic IVDD impairment in vitro.

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Histiocytic sarcoma (HS) is a rare hematological malignancy with limited treatment options, and it is also prone to complications such as hemophagocytic lymphohistiocytosis (HLH) in the later stages of the disease, leading to difficulties in treatment and poor prognosis. It highlights the importance of developing novel therapeutic agents. Herein, we present a case of a 45-year-old male patient who was diagnosed with PD-L1-positive HS with HLH.

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Background: Senescence and apoptosis of the nucleus pulposus cells (NPCs) are essential components of the intervertebral disc degeneration (IDD) process. Senescence and anti-apoptosis treatments could be effective ways to delay or even stop disc degeneration. IDD has been treated with Oliver (Du Zhong, DZ) and its active ingredients.

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Lung cancer has the highest mortality rate among all malignancies. Non-micro pulmonary nodules are the primary manifestation of early-stage lung cancer. If patients can be detected with nodules in the early stage and receive timely treatment, their survival rate can be improved.

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Among primary bone cancers, osteosarcoma is the most common, peaking between the ages of a child's rapid bone growth and adolescence. The diagnosis of osteosarcoma requires observing the radiological appearance of the infected bones. A common approach is MRI, but the manual diagnosis of MRI images is prone to observer bias and inaccuracy and is rather time consuming.

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Sepsis is a global health care issue that affects millions of people. DNA methyltransferase I (DNMT1)-mediated DNA methylation is involved in a number of human diseases by affecting many types of cellular progression events. However, the role and underlying molecular mechanism of DNMT1 in development of sepsis remain largely unknown.

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Reportedly, dysfunction of human pulmonary arterial smooth muscle cells (PASMCs) is associated with the pathogenesis of pulmonary arterial hypertension (PAH). Herein, the role of miR-509-5p in hypoxia-induced PASMCs and the underlying mechanism were explored. PASMCs were cultured under both normoxia and hypoxia conditions.

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At present, human health is threatened by many diseases, and lung cancer is one of the most dangerous tumors that threaten human life. In most developing countries, due to the large population and lack of medical resources, it is difficult for doctors to meet patients' needs for medical treatment only by relying on the manual diagnosis. Based on massive medical information, the intelligent decision-making system has played a great role in assisting doctors in analyzing patients' conditions, improving the accuracy of clinical diagnosis, and reducing the workload of medical staff.

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Accurate segmentation and partitioning of lesions in PET images provide computer-aided procedures and doctors with parameters for tumour diagnosis, staging and prognosis. Currently, PET segmentation and lesion partitioning are manually measured by radiologists, which is time consuming and laborious, and tedious manual procedures might lead to inaccurate measurement results. Therefore, we designed a new automatic multiprocessing scheme for PET image pre-screening, noise reduction, segmentation and lesion partitioning in this study.

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Prostate cancer (PCa) is one of the main diseases that endanger men's health worldwide. In developing countries, due to the large number of patients and the lack of medical resources, there is a big conflict between doctors and patients. To solve this problem, an auxiliary medical decision system for prostate cancer was constructed.

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To observe thoracolumbar segmental mobility using kinetic magnetic resonance imaging (kMRI) in patients with minimal thoracolumbar spondylosis and establish normal values for translational and angular segmental motion as well as the relative contribution of each segment to total thoracolumbar segmental motion in order to obtain a more complete understanding of this segmental motion in healthy and pathological conditions.Mid-sagittal images obtained by weight-bearing, multi-position kMRI in patients with symptomatic low back pain or radiculopathy were reviewed. The translational motion and angular variation of each segment from T10-L2 were calculated using MRAnalyzer Automated software.

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Hamartoma of mature cardiac myocytes is an extremely rare type of benign cardiac tumor with a slow growth rate and generally occurs in adults. We report a case with hamartoma of mature cardiac myocytes of the right auricle demonstrating intense F-FDG uptake and a large amount of pericardial effusion on PET/CT mimicking malignancy in a 41-year-old man. Hamartoma of mature cardiac myocytes should be considered among the differential diagnoses when an F-FDG-avid primary focal cardiac mass is found in patients with malignant features on PET/CT imaging.

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The uneven distribution of medical resources is a serious problem in developing countries. Those seeking timely treatment have difficulty choosing the right hospital. To found sustainable development with medical system, this paper establishes a model of the hospital confidence evaluation index by combining national evaluation and a third-party evaluation.

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The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus serotype 2 (AAV)]; and IDD + AAV2‑BMP2 (106, 108 and 1010). IL‑1β was used to treat primary nucleus pulposus (NP) cells to mimic IDD in vitro.

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Rationale: Malignant hepatic epithelioid hemangioendotheliom (HEH) is a rare vascular tumor of endothelial origin, with multiple metastases to the spleen. This report describes a diffuse HEH with splenic metastasis on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images and delayed mutifocal bone metastasis after liver transplantation (LTx).

Patient Concerns: A 30-year-old male was admitted to our hospital with a complaint of abdominal distension, fatigue, and anorexia for 2 months.

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Non-small cell lung cancer (NSCLC) is a high risk cancer and is usually scanned by PET-CT for testing, predicting and then give the treatment methods. However, in the actual hospital system, at least 640 images must be generated for each patient through PET-CT scanning. Especially in developing countries, a huge number of patients in NSCLC are attended by doctors.

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Purpose: The purpose of this study was to examine the movement of the spinal cord and its relationship to the spinal canal in patients with mild spondylosis using kinetic magnetic resonance imaging (kMRI).

Methods: Weight-bearing, multiposition kMRI was performed on symptomatic patients through a full range of flexion-extension. A total of 52 study patients were selected based on the C2-C7 Cobb angle of sagittal alignment: lordotic (from 30 to 45 degrees).

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Study Design Retrospective cohort study. Objective The objective was to measure the change of flavum ligament diameter during positional changes of the cervical spine using kinetic magnetic resonance imaging (MRI) and to examine the correlational diameter changes of the flavum ligament, disk bulging, and the spinal canal from extension to flexion positions. Methods One hundred eight-nine patients underwent kinetic MRI in neutral, extension, and flexion positions.

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Hepatoid adenocarcinoma is a rare extrahepatic tumor that shows clinicopathologic and morphologic similarities to hepatocellular carcinoma. An FDG PET/CT imaging of primary mediastinal hepatoid adenocarcinoma in a 43-year-old man who had an elevated serum alpha-fetoprotein level was reported in this case. The patient's mediastinal lesion had avid FDG uptake.

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