Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery.

With the unique photo-physical properties and strong bio-compatibility. Quantum dots (QDs) have sparked interest in biomedical fields such as imaging, biosensing and therapeutics. However, the low stability and insufficient tumor specificity have largely constrained their potential biomedical applications.

The risk of hepatobiliary complications in Clonorchis and Opisthorchis infection: A systematic review and meta-analysis.

Clonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are the three important liver flukes, infecting approximately 25 million people worldwide. Despite the reporting of the carcinogenesis of these liver flukes, the comprehensive and systematic analysis of the pathogenicity of these parasites in hepatobiliary system is still not sufficient. We conducted a thorough systematic review and search for published articles in MEDLINE, Embase, Cochrane Library, China National Knowledge Infrastructure databases until early 2024.

MicroRNA-216a-5p Alleviates Acute Kidney Injury of Mice via Suppressing FAS Ligand Expression.

Introduction: The aim of this present work was to investigate the mechanism of the microRNA (miR)-216a-5p/FASL axis in mice with acute kidney injury (AKI).

Methods: Mice kidney ischemia/reperfusion (I/R) injury was used as AKI models in this study. I/R mice were injected with miR-216a-5p- and FASL-related constructs to investigate potential mechanisms of kidney protection.

Investigating the impact of cellulose microgel nanofabrication on the rheological properties of this binary rheology modifier.

The multifunctionality of advanced laundry detergents primarily relies on the inclusion of functional solid particles, such as pearlescent powder, enzymes, and perfume microcapsules. However, the high-content surfactants in these detergents can render most existing suspending rheology modifiers ineffective, making it challenging to achieve uniform suspension of these functional particles. This compromises the overall functionality of laundry products.

Comparative metabolomics profiling reveals the unique bioactive compounds and astringent taste formation of rosehips.

Rosehips are a prominent source of numerous bioactive compounds. However, despite their extensive potential, the metabolic profiles among different rosehip species have not been fully elucidated. In this study, 523 secondary metabolites from rosehips of 12 Rosa species were identified using ultra-high-performance liquid chromatography-tandem mass spectrometry.

Dexmedetomidine Alleviates Ischemia/Reperfusion-Associated Acute Kidney Injury by Enhancing Autophagic Activity the α2-AR/AMPK/mTOR Pathway.

Background: Dexmedetomidine (DEX) reportedly protects against ischemia-reperfusion (I/R) injury and associated damage to the kidneys, but the underlying mechanisms have yet to be established.

Methods: Unilateral nephrectomy was performed in Wistar rats, and the remaining kidney was clamped for 1 h prior to reperfusion to establish an experimental model system. These animals were then randomized into Sham, DEX + Sham, DEX + I/R, ATI (Altepamizole, α2-adrenergic receptor inhibitor) + DEX + I/R, and 3-MA (3-methyladenine, autophagy inhibitor) + DEX + I/R groups.

PEI functionalized cell membrane for tumor targeted and glutathione responsive gene delivery.

Polyethylenimine (PEI) is a broadly exploited cationic polymer due to its remarkable gene-loading capacity. However, the high cytotoxicity caused by its high surface charge density has been reported in many cell lines, limiting its application significantly. In this study, two different molecular weights of PEI (PEI10k and PEI25k) were crosslinked with red blood cell membranes (RBCm) via disulfide bonds to form PEI derivatives (RMPs) with lower charge density.

TCOD: an integrated resource for tropical crops.

Tropical crops are vital for tropical agriculture, with resource scarcity, functional diversity and extensive market demand, providing considerable economic benefits for the world's tropical agriculture-producing countries. The rapid development of sequencing technology has promoted a milestone in tropical crop research, resulting in the generation of massive amount of data, which urgently needs an effective platform for data integration and sharing. However, the existing databases cannot fully satisfy researchers' requirements due to the relatively limited integration level and untimely update.

The combined plasma membrane coating and cluster bombing strategy for improved tumor-targeting gene delivery of silicon nanoclusters.

With the promising biosafety and favorable cell imaging efficiency, silicon quantum dots (SiQDs) was broadly exploited as non-viral gene carriers in recent years. However, the low transfection efficiency and weak targeting ability hindered its further clinical applications. In this study, the combined plasma membrane coating and cluster bombing strategy was adopted to enhance the gene delivery potential of silicon quantum dots nanoclusters (SiNC).

Effectiveness of ultraviolet-C disinfection systems for reduction of multi-drug resistant organism infections in healthcare settings: A systematic review and meta-analysis.

This study aimed to summarise the findings of the studies assessing the effectiveness of ultraviolet C (UV-C) room disinfection in reducing the incidence rate of healthcare-associated multi-drug-resistant organism (MDRO) infections. A systematic screening was conducted using PubMed, EMBASE, and Scopus for randomised controlled trials (RCTs), quasi-experimental studies, and before-after studies, which assessed the efficacy of the UV-C disinfectant system in reducing the incidence of MDRO infections. A random-effects model was used for the analysis.

Development of a biomimetic DNA delivery system by encapsulating polyethyleneimine functionalized silicon quantum dots with cell membranes.

Quantum dots (QDs) are renowned for their remarkable optoelectronic properties, making them suitable for applications such as bioimaging and optoelectronics. However, their use in gene delivery has been restricted due to the low DNA loading capacity. This study aimed to develop a biomimetic DNA delivery system by encapsulating polyethyleneimine (PEI) functionalized silicon QDs (SiQDs) with cell membranes and evaluate its potential as a gene vector in vitro.

cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway.

Cyclic GMP-AMP synthase (cGAS), as a cytosolic DNA sensor, plays a crucial role in antiviral immunity, and its overactivation induces excess inflammation and tissue damage. Macrophage polarization is critically involved in inflammation; however, the role of cGAS in macrophage polarization during inflammation remains unclear. In this study, we demonstrated that cGAS was upregulated in the LPS-induced inflammatory response via the TLR4 pathway, and cGAS signaling was activated by mitochondria DNA in macrophages isolated from C57BL/6J mice.

Executive control of freestyle skiing aerials athletes in different training conditions.

Introduction: Due to the actual limitation of training conditions, the freestyle skiing aerials winter training term is short. Training tasks such as adaptability training and developing new skills are needed in summer training. When facing different training environments, freestyle skiing aerial athletes' executive control over their abilities could be affected, which can affect their performance.

TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.

Tripartite motif protein (TRIM) 50 is a new member of the tripartite motif family, and its biological function and the molecular mechanism it is involved in remain largely unknown. The NOD-like receptor family protein (NLRP)3 inflammasome is actively involved in a wide array of biological processes while mechanisms of its regulation remain to be fully clarified. Here, we demonstrate the role of TRIM50 in NLRP3 inflammasome activation.

Fabrication of zein-based hydrophilic nanoparticles for efficient gene delivery by layer-by-layer assembly.

As a natural biological macromolecule, zein has broad application prospects in drug delivery due to its unique self-assembly properties. In this work, zein/sodium alginate (Zein/SA) nanocomposites were prepared by a pH-cycle method, Then Zein/SA/PEI (ZSP) nanocomposites were prepared by efficient layer-by-layer assembly method, ZSP nanocomposite of higher transfection performance was further labeled by folic acid (FA). After characterizing the physicochemical properties of ZSP by various methods, the potential of ZSP as a gene delivery vehicle was explored in vitro.

Severe side effects caused by parenteral nutrition therapy with fat emulsion (10%)/amino acids (15)/glucose (20%) injection: 2 case reports.

Background: Nutritional support containing fat emulsion, amino acids, and glucose is widely applied to improve the metabolic status of tumor patients, however, the related adverse reactions have been rarely reported. Here, we reported two patients with tumor who received parenteral nutrition (PN) with injections of fat emulsion (10%)/amino acids (15)/glucose (20%) experienced severe side effects, and subsequently provide guidance information for the clinical administration of fat emulsion (10%)/amino acids (15)/glucose (20%) injection.

Case Description: The first case was a 69-year-old female, diagnosed with cholangiocarcinoma T2N1MX IIIB by magnetic resonance imaging (MRI).

Widely Targeted Metabolic Profiling Reveals Differences in Polyphenolic Metabolites during f. Fruit Development and Ripening.

Rose hips are rich in various nutrients and have long been used for food and medicinal purposes. Owing to the high phenolic content, rose hips can be used as natural antioxidants. In this study, ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to conduct a widely targeted metabolomics analysis on the polyphenolic components of f.

Stacking polymer microspheres matrix: a facile, practical, and energy-saving strategy for suppression of acid mist.

The electroplating, electrolysis, and pickling industrial processes would generate numerous gas pollutes, acid mist, which could not be essentially diminished due to its synthesis mechanism and cause gaseous environmental pollution, equipment corrosion, and endanger workers' health. In this study, a facile, practical, and energy-saving acid mist suppression system was constructed by introducing a stacking microsphere matrix as a floating porous phase on the acid solution and not causing secondary pollution. The mechanism of this green acid mist suppression strategy mainly focused on size-selective blocking of acid mist droplets by dense stacking microsphere layer and dissipation of floating kinetic energy of bubbles in the acid mist.

An improved solvent evaporation method to produce poly (lactic acid) microspheres via foam-transfer.

The aim of this work was to study an improved solvent evaporation method to prepare poly (lactic acid) (PLA) microspheres via foam-transfer. Since the foaming process and its transfer were critical to the improved method, they have been studied. Additionally, the delivery capability of foams was studied as a function of the oil/water ratio, the stirring rate, the concentration of polyvinyl alcohol (PVA) and ethanol (EtOH) in the aqueous phase (ω ω).

Psychometric evaluation of the characteristics of resilience in sports team inventory in China.

This study examines the reliability and validity of the Characteristics of Resilience in Sports Teams Inventory (CREST) in Chinese team athletes. A sample of 659 athletes (male = 355, female = 304) aged from 16-34 (M = 20.08, SD = 2.

Designing and preparing supramolecular fluorescent probe based on carminic acid and γ-cyclodextrins and studying their application for detection of 2-aminobenzidazole.

Supramolecular fluorescent probe, which was designed and modeled from carminic acid (CA) and γ-cyclodextrins (γ-CDs), was initially qualified and stated comprehensively. Fluorescence intensity of CA could be dramatically enhanced ∼850 a.u.

NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway.

Nucleotide binding oligomerization domain 2 (NOD2) is a recognized innate immune sensor which can initiate potent immune response against pathogens. Many innate immune sensors have been reported to be of great importance in carcinogenesis. However, the role of NOD2 in cancer is not well understood.

Relationships between talent development environments and mental toughness: The role of basic psychological need satisfaction.

Although the talent development environment and mental toughness are critical for athletes to realise their athletic potential, there is a dearth of literature on whether the talent development environment can enhance mental toughness among those athletes who are identified with athletic potential (i.e., talented athletes).