Construction of ferroptosis-related gene signatures for identifying potential biomarkers and immune cell infiltration in osteoarthritis.

Osteoarthritis (OA) is a comprehensive joint disorder. The specific genes that trigger OA and the strategies for its effective management are not fully understood. This study focuses on identifying key genes linked to iron metabolism that could influence both the diagnosis and therapeutic approaches for OA.

Efficacy and Safety of Insulin Degludec/Insulin Aspart versus Biphasic Insulin Aspart 30 in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.

Background: We systematically reviewed and analyzed the efficacy and safety of insulin degludec/insulin as-part (IDegAsp) versus biphasic insulin aspart 30 (BIAsp 30) in patients with type 2 diabetes (T2D).

Methods: We used computers to search the Embase, PubMed, Clinical Trials, and the Cochrane Library database, and collected randomized controlled trials (RCTs) on the treatment of IDegAsp versus BIAsp 30 in T2D patients. The research period was from the establishment of the database to May 19, 2023.

The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) is a common metabolic condition during pregnancy, posing risks to both mother and fetus. CircRNAs have emerged as important players in various diseases, including GDM. We aimed to investigate the role of newly discovered circRNA, hsa_circ_0042260, in GDM pathogenesis.

Ether-Water Co-Solvent Electrolytes Enhanced Vanadium Oxide Cathode Cyclic Behaviors for Zinc Batteries.

Vanadium-based compounds are fantastic cathodes for aqueous zinc metal batteries due to the high specific capacity and excellent rate capability. Nevertheless, the practical application has been hampered by the dissolution of vanadium in traditional aqueous electrolytes owing to the strong polarity of water molecules. Herein, we propose a hybrid electrolyte made of Zn(ClO) salt in tetraethylene glycol dimethyl ether (G4) and HO solvents to upgrade the cycle life of Zn//KVO battery.

Engineering of heterointerface of ultrathin carbon nanosheet-supported CoN/MnO enhances oxygen electrocatalysis for rechargeable Zn-air batteries.

Designing bifunctional electrocatalysts with outstanding reactivity and durability towards the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) has remained a long-term aim for metal-air batteries. Achieving the high level of fusion between two distinct metal components to form bifunctional catalysts with optimized heterointerfaces and well-defined morphology holds noteworthy implications in the enhancement of electrocatalytic activity yet challenging. Herein, the fabrication of numerous heterointerfaces of CoN/MnO is successfully realized within ultrathin carbon nanosheets via a feasible self-templating synthesis strategy.

RNA pseudouridine modification in plants.

Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models, the recent findings provide strong evidence for the critical role of pseudouridine in plants.

Diagnostic Performance of Metagenomic Next⁃Generation Sequencing in the Diagnosis of Prosthetic Joint Infection Using Tissue Specimens.

Purpose: The purpose of this study was to evaluate the ability of metagenomic next-generation sequencing (mNGS) diagnosing prosthetic joint infection (PJI) using tissue from hip/knee rapidly and precisely, especially in patients who had received antibiotic treatment within the preceding two weeks.

Methods: From May 2020 to March 2022, 52 cases with suspected PJI were enrolled. mNGS was performed on surgical tissue samples.

Selective CO Photoreduction to Acetate at Asymmetric Ternary Bridging Sites.

Photoreduction of CO is a promising strategy to synthesize value-added fuels or chemicals and realize carbon neutralization. Noncopper catalysts are seldom reported to generate C products, and the selectivity over these catalysts is low. Here, we design rich-interface, heterostructured InO/InP (r-InO/InP) for highly competitive photocatalytic CO-to-CHCOOH conversion with a productivity of 96.

Cytological and Biochemical Analyses of Lymphatic Fluid from Patients with Lymphatic Malformations.

Intracystic hemorrhage from lymphangiomas is a common phenomenon in lymphatic malformations (LMs); however, little is known about the associated compositional changes in the lymphatic fluid. We prospectively collected lymphatic fluid from children with LMs. Lymphatic fluid was divided depending on the bleeding status into the bleeding and nonbleeding groups.

The Effect of Dexmedetomidine on the Prognosis of Mechanically Ventilated Patients with Sepsis: A Meta-Analysis of Randomized Controlled Trials.

Background: Dexmedetomidine (Dex), as a new and highly selective α adrenergic receptor agonist, has been widely used in mechanically ventilated patients. In the present study, we used meta-analysis to study the effect of Dex on the prognosis of mechanically ventilated patients with sepsis.

Methods: We searched PubMed, Cochrane clinical trial, EMBASE, Web of Science, and Chinese biomedical literature database to analyze relevant literature published from January 2000 to January 2021.

Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma.

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm associated with the Kasabach-Merritt phenomenon (KMP), which is a consumptive coagulopathy with associated potentially life-threatening thrombocytopenia. There are no standardized treatment protocols for the management of KHE with KMP. Moreover, there are limited reports regarding the treatment of cases of rebound.

The Arabidopsis Mitochondrial Pseudouridine Synthase Homolog FCS1 Plays Critical Roles in Plant Development.

As the most abundant RNA modification, pseudouridylation has been shown to play critical roles in Escherichia coli, yeast and humans. However, its function in plants is still unclear. Here, we characterized leaf curly and small 1 (FCS1), which encodes a pseudouridine synthase in Arabidopsis.

Utility of Human Neutrophil Lipocalin as a Diagnosing Biomarker of Prosthetic Joint Infection: A Clinical Pilot Study.

Purpose: The discrimination of prosthetic joint infection (PJI) from aseptic failure is regarded as a major clinical challenge. The key function of human neutrophil lipocalin (HNL) in regulating bacterial infection rationalizes its potential as a biomarker to diagnose PJI. This work evaluated the accuracy of serum human neutrophil lipocalin as a biomarker to diagnose PJI.

Integrating Bimetal Alloy into N-Doped Carbon Nanotubes@Nanowires Superstructure for Zn-Air Batteries.

Exploring bifunctional oxygen electrocatalysts with low cost and high performance is critical to the development of rechargeable zinc-air batteries, but it still remains a huge challenge. In this work, a "coordination construction-pyrolysis/self-catalyzed growth" approach was employed to fabricate branches@trunks-like, N-doped carbon nanotubes@nanowires superstructure with uniformly incorporated CoFe alloy nanoparticles (CoFe@CNTs-NWs). The rational design of such hierarchical architecture could effectively enlarge the exposure of active sites, modulate their electronic structure, and assist the electron transfer and mass diffusion, thus benefiting both ORR and OER.

Evaluating the expression of tumorigenic long noncoding RNAs in circulating exosomes isolated from non-small-cell lung cancer patients.

To evaluate the correlation of long noncoding RNAs (lncRNAs) expression in circulating exosomes and the cancerous and noncancerous tissues in patients with non-small-cell lung carcinoma. The relative expression of the four lncRNAs including LUADT1, MALAT1, NEAT1 and MIAT between tumor tissue, adjacent noncancerous tissues and circulating exosomes were evaluated by quantitative reverse transcription PCR. The relative expression of the lncRNAs, including LUADT1, MALAT1 and NEAT1, was upregulated and MIAT was downregulated in tumor tissue compared with noncancerous tissue samples.

The MIEL1-ABI5/MYB30 regulatory module fine tunes abscisic acid signaling during seed germination.

The transcription factor ABSCISIC ACID INSENSITIVE5 (ABI5) plays a crucial role in abscisic acid (ABA) signaling during seed germination. However, how ABI5 is regulated during this process is poorly understood. Here, we report that the ubiquitin E3 ligase MIEL1 and its target transcription factor MYB30 modulate ABA responses in Arabidopsis thaliana during seed germination and seedling establishment via the precise regulation of ABI5.

The maize single-nucleus transcriptome comprehensively describes signaling networks governing movement and development of grass stomata.

The unique morphology of grass stomata enables rapid responses to environmental changes. Deciphering the basis for these responses is critical for improving food security. We have developed a planta platform of single-nucleus RNA-sequencing by combined fluorescence-activated nuclei flow sorting, and used it to identify cell types in mature and developing stomata from 33,098 nuclei of the maize epidermis-enriched tissues.

Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses.

Plants face a more volatile environment than other organisms because of their immobility, and they have developed highly efficient mechanisms to adapt to stress conditions. Transcription factors, as an important part of the adaptation process, are activated by different signals and are responsible for the expression of stress-responsive genes. MYB transcription factors, as one of the most widespread transcription factor families in plants, participate in plant development and responses to stresses by combining with MYB -elements in promoters of target genes.

Engineering Two-Phase Bifunctional Oxygen Electrocatalysts with Tunable and Synergetic Components for Flexible Zn-Air Batteries.

Metal-air batteries, like Zn-air batteries (ZABs) are usually suffered from low energy conversion efficiency and poor cyclability caused by the sluggish OER and ORR at the air cathode. Herein, a novel bimetallic Co/CoFe nanomaterial supported on nanoflower-like N-doped graphitic carbon (NC) was prepared through a strategy of coordination construction-cation exchange-pyrolysis and used as a highly efficient bifunctional oxygen electrocatalyst. Experimental characterizations and density functional theory calculations reveal the formation of Co/CoFe heterostructure and synergistic effect between metal layer and NC support, leading to improved electric conductivity, accelerated reaction kinetics, and optimized adsorption energy for intermediates of ORR and OER.

Construction of self-supporting, hierarchically structured caterpillar-like NiCoS arrays as an efficient trifunctional electrocatalyst for water and urea electrolysis.

In this study, we have developed intriguing self-supporting caterpillar-like spinel NiCo2S4 arrays with a hierarchical structure of nanowires on a nanosheet skeleton, which can be used as a self-supporting trifunctional electrocatalyst for the oxygen evolution reaction (OER), hydrogen evolution reaction (HER) and urea oxidation reaction (UOR). The caterpillar-like NiCo precursor arrays are first in situ grown on carbon cloth (NiCo2O4/CC) by a facile hydrothermal reaction, which is followed by an anion exchange process (or sulfuration treatment) with Na2S to form self-supporting spinel NiCo2S4 arrays (NiCo2S4/CC) with a roughened nanostructure. Taking advantage of the bimetallic synergistic effect, the unique hierarchical nanostructure, and the self-supporting nature, the resultant NiCo2S4/CC electrode exhibits high activities toward the OER, HER and UOR, which are highly superior to the monometallic counterparts of NiS nanosheets and Co9S8 nanowires on a carbon cloth substrate.

Self-Supported Vanadium Carbide by an Electropolymerization-Assisted Method for Efficient Hydrogen Production.

Exploring efficient electrodes toward the hydrogen evolution reaction (HER) remains a great challenge for large-scale hydrogen production. Owing to its high earth abundance, low electrical resistivity, and small density, vanadium carbide (VC) is a promising HER electrode candidate but has been rarely explored. In this work, VC nanoparticles encased in nitrogen-doped carbon matrix on carbon cloth (VC@NC/CC) were prepared as a binder-free HER cathode through electropolymerization followed by carbothermal reduction under argon.

DSA-guided percutaneous sclerotherapy for children with oropharyngeal low-flow venous malformation.

The present study investigated the efficacy and safety of digital subtraction angiography-guided 3% polidocanol foam sclerosing agent, as well as the combination of pingyangmycin and dexamethasone, for the treatment of children with oropharyngeal low-flow venous malformation. A total of 27 children with 35 lesions with oropharyngeal low-flow venous malformation were included. The subjects were randomly divided into Groups A (13 patients with 16 lesions, treated with 3% polidocanol foam sclerosing agent) and B (14 patients with 19 lesions, treated with pingyangmycin + dexamethasone), respectively.

autologous growth of self-supporting NiFe-based nanosheets on nickel foam as an efficient electrocatalyst for the oxygen evolution reaction.

A highly efficient and low-cost oxygen evolution reaction electrocatalyst is essential for water splitting. Herein, a simple and cost-effective autologous growth method is developed to prepare NiFe-based integrated electrodes for water oxidation. In this method, a Ni(OH) nanosheet film is first developed on nickel foam by oxidative deposition in a chemical bath solution.

Rational construction of self-supported triangle-like MOF-derived hollow (Ni,Co)Se arrays for electrocatalysis and supercapacitors.

In this work, we have adopted a facile three-step method for constructing an intriguing bifunctional electrode of self-supported hollow (Ni,Co)Se2 arrays with a metal-organic framework (MOF) precursor. The triangle-like cobalt-based MOF arrays are first grown on a carbon cloth at room temperature, which is followed by an ion exchange/etching process with Ni(NO3)2 to form a critical hollow nanostructure with an incorporated hetero-metal element. The intermediate is then transformed into the final product through solvothermal selenization treatment.