Comparative Evaluation Between Cutting of the Intersphincteric Space vs Cutting Seton in High Anal Fistula: A Randomized Controlled Trial.

Background: This study compared the efficacy of cutting of the intersphincteric space (COIS) with cutting seton (CS) procedure in treating high anal fistula.

Methods: Patients diagnosed with high anal fistula were allocated into groups, who randomly received COIS and CS procedures. The primary outcome was wound healing time.

Development and validation of a prediction model for hypoproteinemia after traumatic spinal cord injury: A multicenter retrospective clinical study.

A multicenter retrospective analysis of conventionally collected data. To identify the potential causes of hypoproteinemia after traumatic spinal cord injury (TSCI) and provide a diagnostic model for predicting an individual likelihood of developing hypoproteinemia. Hypoproteinemia is a complication of spinal cord injury (SCI), an independent risk factor for respiratory failure in elderly patients with SCI, and a predictor of outcomes in patients with cervical SCI.

Development and validation of a risk nomogram to estimate risk of hyponatremia after spinal cord injury: A retrospective single-center study.

Objective: This study aimed to establish a nomogram-based assessment for predicting the risk of hyponatremia after spinal cord injury (SCI).

Design: The study is a retrospective single-center study.

Participants: SCI patients hospitalized in the First Affiliated Hospital of Guangxi Medical University.

Estimation of surface ozone concentration over Jiangsu province using a high-performance deep learning model.

Recently, the global background concentration of ozone (O) has demonstrated a rising trend. Among various methods, groun-based monitoring of O concentrations is highly reliable for research analysis. To obtain information on the spatial characteristics of O concentrations, it is necessary that the ground monitoring sites be constructed in sufficient density.

Proton-Conductive Polyoxometalate Architectures Constructed from Lanthanide-Incorporated Polyoxoniobate Cages.

Two new extended polyoxometalate (POM) architectures based on lanthanide-incorporated polyoxoniobate (Ln-incorporated PONb) cages, namely, H[Cu(en)]{K(HO)[Cu(en)][Cu(trz)(en)(OH)][DyCu(en)(CO)(HO)(OH)][Dy(HO)][DyNbO(HO)]}·60HO (, en = ethylenediamine) and H[Cu(en)]{[Cu(en)][Dy(CO)(HO)][(Nb(OH)(HO)O]}·54HO (), have been successfully synthesized and structurally characterized, demonstrating a feasible strategy to develop functional POM materials. In addition, the proton conductivity and magnetic behaviors of both and were studied.

New Deep Learning Model to Estimate Ozone Concentrations Found Worrying Exposure Level over Eastern China.

Ozone (O3), whose concentrations have been increasing in eastern China recently, plays a key role in human health, biodiversity, and climate change. Accurate information about the spatiotemporal distribution of O3 is crucial for human exposure studies. We developed a deep learning model based on a long short-term memory (LSTM) network to estimate the daily maximum 8 h average (MDA8) O3 across eastern China in 2020.

Two high-nuclearity isopolyoxoniobates containing {Nb O}-based helical nanotubes for the decomposition of chemical warfare agent simulants.

Two inorganic-organic hybrid isopolyoxoniobates (1 and 2) based on new high-nuclearity {NbO} clusters have been synthesized under hydrothermal conditions. In particular, the combination of the unique {NbO} clusters with copper-amine complexes has led to rare helical nanotubes, which are further linked by alkali metal cations or copper-amine complexes into two 2D similar bamboo-raft-like layered networks (1 and 2), respectively. Compound 1 exhibits effective base-catalytic decomposition of chemical warfare agent simulants dimethyl methylphosphonate (DMMP) and diethyl cyanophosphonate (DECP).

A Series of Cube-Shaped Polyoxoniobates Encapsulating Octahedral CuX O Clusters With Hydrolytic Decomposition for Chemical Warfare Agents.

This study reported a series of cube-shaped polyoxoniobates, {MCuO)(CuXO)(Nb(OH)O)} [M = Nb(1, 2), Ln(3), X = I(1, = 3, = 3; 2, = 5, = 1), Br(3, = 5, = 1)]. As the first octahedral CuXO cluster incorporated polyoxoniobate, the cube-shaped three-shell structure of {MCuO)(CuXO)(Nb(OH)O)} polyanion contains a {MCuO} body-centered cuboctahedron, a {CuXO} octahedron and a {Cu(Nb(OH)O)} cube. Compounds 1, 2, 3 show effective catalytic activities for the hydrolytic decomposition of chemical warefare agent simulants.

An Improved Method for Road Extraction from High-Resolution Remote-Sensing Images that Enhances Boundary Information.

At present, deep-learning methods have been widely used in road extraction from remote-sensing images and have effectively improved the accuracy of road extraction. However, these methods are still affected by the loss of spatial features and the lack of global context information. To solve these problems, we propose a new network for road extraction, the coord-dense-global (CDG) model, built on three parts: a coordconv module by putting coordinate information into feature maps aimed at reducing the loss of spatial information and strengthening road boundaries, an improved dense convolutional network (DenseNet) that could make full use of multiple features through own dense blocks, and a global attention module designed to highlight high-level information and improve category classification by using pooling operation to introduce global information.

High-dimensional Polyoxoniobates Constructed from Lanthanide-incorporated High-nuclear {[Ln(H O) ] [Nb O (H O) ] } Secondary Building Units.

In this work, two rare high-dimensional polyoxoniobates with formulas of H [Cu(en)(H O) ][Cu(en) ] [Dy(H O) ] [Nb -O (H O) ]  ⋅ 36H O (1) and H K[Cu(en) (H O)] [Cu(en) ] -[Eu(H O) ] [Nb O (H O) ]  ⋅ 2en ⋅ 45H O (2) have been obtained under hydrothermal conditions. These extended materials are constructed from lanthanide-incorporated triangular-prism-like polyoxoniobate secondary building units (SBUs) {[Ln(H O) ] [Nb O (H O) ] } (Ln=Dy, Eu). 1 and 2 represent the first examples of high-dimensional polyoxometalate materials based on such lanthanide-incorporated triangular-prism-like polyoxoniobate SBUs.

Land Use Classification of the Deep Convolutional Neural Network Method Reducing the Loss of Spatial Features.

Land use classification is a fundamental task of information extraction from remote sensing imagery. Semantic segmentation based on deep convolutional neural networks (DCNNs) has shown outstanding performance in this task. However, these methods are still affected by the loss of spatial features.

A Chromium-Substituted Polyoxoniobate with High Ionic Conductivity.

A rare and novel Cr-substituted polyoxoniobate (PONb), [CrNbO(OH)(HO)], has been synthesized by a combination of hydrothermal and conventional solution methods. The PONb shows an unknown tetrameric structure, which is the largest Cr-containing PONb to date. Interestingly, every two PONb tetramers can be joined together by alkali-metal cations to form a discrete cubelike ionic cluster.

A coastline generalization method that considers buffer consistency.

Coastlines are the boundary between the ocean and land and are an important line feature in spatial data. Coastlines must be adapted via map generalization when they are stored in multi-scale spatial databases. This article presents a new method of coastline generalization that considers the buffer consistency from the original coastline to the generalized coastlines.

Traditional Chinese Medicine Extract from Huaier Increases the Expression of Duffy Antigen Receptor for Chemokines and Reduces the Expression of Its Ligands.

Aims: The aim of the present study is to investigate whether the aqueous extract from Huaier, a traditional Chinese medicine (TCM), can affect the expression of Duffy antigen receptor for chemokines (DARC) and its ligands. Moreover, we compare the status of DARC in primary and metastatic breast cancer tissues from the same patient.

Methods: Immunohistochemistry was used to detect the expression of DARC in primary and metastatic focuses in 30 patients with breast cancer.

{Nb O (OH) (CO ) }: A Macromolecular Polyoxometalate with Close to 300 Niobium Atoms.

A protein-sized (ca. 4.2×4.

A Series of Banana-Shaped 3d-4f Heterometallic Cluster Substituted Polyoxometalates: Syntheses, Crystal Structures, and Magnetic Properties.

Four seven-nuclearity 3d-4f heterometallic cluster {FeLnO} substituted polyoxometalates (HPz)KFeLn(μ-O)(B-α-GeWO)(GeWO)· xHO (1-Ln, Pz = piperazine, Ln = Tb, Dy, Ho, Er for x = 27, 25, 25, 24, respectively) have been hydrothermally prepared and structurally characterized by single-crystal X-ray diffraction, powder X-ray diffraction, infrared spectrometry, thermogravimetric analyses, elemental analyses, and electrospray ionization mass spectrometry. Single-crystal X-ray diffraction analyses revealed that 1-Ln contain an unprecedented banana-shaped polyanion constructed from an iron-lanthanide heterometallic {FeLnO} cluster, two trilacunary {B-α-GeWO} units, and one hexalacunary {GeWO} fragment. The magnetic susceptibility surveying proved the presence of antiferromagnetic coupling in 1-Ln.

Record High-Nuclearity Polyoxoniobates: Discrete Nanoclusters {Nb }, {Nb }, and {Nb }, and Extended Frameworks Based on {Cu Nb } and {Cu Nb }.

A series containing the highest nuclearity polyoxoniobate (PONb) nanoclusters, ranging from dimers to tetramers, has been obtained. They include one 114-nuclear {Li ⊂Nb O }, one 81-nuclear {Li K⊂Nb O }, and one 52-nuclear {H Nb O }. The Nb nuclearity of these PONbs is remarkably larger than those of all known high-nuclearity PONbs (≤32).

[Impacts of high-volume hemofiltration on hemodynamics and vascular endothelial permeability in children with septic shock].

Objective: To investigate the effects of high-volume hemofiltration (HVHF) on hemodynamics, vasoactive factors, and vascular endothelial permeability in children with septic shock by a comparative analysis.

Methods: Thirty-six children who were diagnosed with septic shock between January 2013 and September 2014 were randomly divided into control and observation groups (n=18 each). Children in the control group were treated with the standard-volume hemofiltration (SVHF), while children in the observation group were treated with HVHF.

Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562.

Imatinib resistance remains the big hurdle for CML therapy. Previous study reveals that c-myc is important for bcr-abl CML cell proliferation, while its role in imatinib resistance is largely unknown. In this study, we first found that c-myc expression is upregulated in imatinib resistant K562R cells, which in turn enhances the expression of miR-144/451.

Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer.

A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and antigen presentation of DCs, whether this effect occurs in breast cancer is currently unknown. In the present study, we investigated the effect of doxorubicin (ADM)-induced apoptotic MCF-7 breast cancer cells on the activation of DCs.

[Clinical analysis of peripheral blood stem cell mobilization regimens in autologous transplantation for treating non-Hodgkin's lymphoma].

The purpose of this study was to compare the efficacy of CEP plus G-CSF and CVP plus G-CSF regimens in the mobilization and collection of peripheral blood hematopoietic stem cells (PBHSC), and in the hematopoietic recovery. 57 patients with non-Hodgkin's lymphoma (NHL) underwent autologous PBHSC transplantation were analyzed retrospectively. The PBHSC were mobilized and collected by using CEP plus G-CSF and CVP plus G-CSF respectively, and were retransfused into these NHL patients after preconditioning, then the mobilization efficacy, adverse reactions and hematopoietic recovery were analyzed.

miR-153 sensitized the K562 cells to As2O3-induced apoptosis.

Relapse remains the biggest hurdle of leukemia therapy, while elucidating the molecular mechanism holds promise for the solution. Recently, microRNAs are emerging as an important regulator of cell function. In this study, we for the first time found that miR-153 was downregulated in As2O3-induced drug-resistant K562 cells.

Knockdown of SOD1 sensitizes the CD34+ CML cells to imatinib therapy.

Leukemia stem cell is thought to be one of the leading causes of imatinib resistance and the resultant relapse of chronic myelogenous leukemia (CML). Eradicating the leukemia stem cells holds the promise of CML treatment. In this study, we found that the CD34+ subpopulation in the CML cell line K562 had a higher expression of SOD1 than that in the CD34 negative cells.

Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein.

The Notch signaling pathway has been implicated in the development of several leukemia and lymphoma. In order to investigate the relationship between Notch signaling and acute myeloid leukemia (AML), in this study, we expressed a recombinant Notch ligand protein, the DSL domain of the human Jagged1 fused with GST (GST-Jag1). GST-Jag1 could activate Notch signaling in the human promyelocytic leukemia cell line HL60, as shown by a reporter assay and the induced expression of Notch effector gene Hes1 and Hes5.