Synergistic Dynamical Decoupling and Circuit Design for Enhanced Algorithm Performance on Near-Term Quantum Devices.

Dynamical decoupling (DD) is a promising technique for mitigating errors in near-term quantum devices. However, its effectiveness depends on both hardware characteristics and algorithm implementation details. This paper explores the synergistic effects of dynamical decoupling and optimized circuit design in maximizing the performance and robustness of algorithms on near-term quantum devices.

Targeted inhibition of pyroptosis a carbonized nanoinhibitor for alleviating drug-induced acute kidney injury.

Pyroptosis is a form of pro-inflammatory programmed cell death and it represents a potential therapeutic target for alleviating drug-induced acute kidney injury (AKI). However, there is a lack of effective and kidney-targeted pyroptosis inhibitors for AKI treatment so far. Herein, we report a pharmacologically active carbonized nanoinhibitor (P-RCDs) derived from 3,4',5-trihydroxystilbene that can preferentially accumulate in the kidneys and ameliorate chemotherapeutic drug-induced AKI by inhibiting pyroptosis.

An Alkaline Nanocage Continuously Activates Inflammasomes by Disrupting Multiorganelle Homeostasis for Efficient Pyroptosis.

Pyroptosis has garnered increasing attention because of its ability to trigger robust antitumor immunity. Pyroptosis is initiated by the activation of inflammasomes, which are regulated by various organelles. The collaboration among organelles offers several protective mechanisms to prevent activation of the inflammasome, thereby limiting the induction of efficient pyroptosis.

Effect of statins use on risk and prognosis of breast cancer: a meta-analysis.

The findings regarding the association between statins use and breast cancer are inconsistent. Given the widely and long-term use of statins as first choice drug for dyslipidemia, we conducted this meta-analysis for better understanding the associations between statins use and the risk and prognosis of breast cancer. Articles regarding effect of statins use on risk, prognosis of breast cancer and published before January 2021 were searched in the following databases: Web of Science, PubMed, EMBASE, Medline and Google Scholar.

Experimental Investigation on the Freeze-Thaw Resistance of Steel Fibers Reinforced Rubber Concrete.

The reuse of rubber in concrete results in two major opposing effects: an enhancement in durability and a reduction in mechanical strength. In order to strengthen the mechanical properties of rubber concrete, steel fibers were added in this research. The compressive strength, the four-point bending strength, the mass loss rate, and the relative dynamic elastic modulus of steel fiber reinforced rubber concrete, subjected to cyclic freezing and thawing, were tested.

Diastereoselective Syntheses of Spiro[indoline-3,4'-pyridin]-2-yl Carbamates via AgOTf/PhP-Catalyzed Tandem Cyclizations of Tryptamine-Ynesulfonamides.

Spiro[indoline-3,4'-piperidine] is a significant structural scaffold in numerous polycyclic indole alkaloids with a variety of bioactivities. In this study, a synthetic strategy was developed to access spiro[indoline-3,4'-pyridin]-2-yl carbamate via an AgOTf/PPh-catalyzed tandem cyclization of tryptamine-ynesulfonamides. The unique feature of this strategy is the efficient intermolecular capturing of the in situ generated spiroindoleninium intermediates with carbamates, leading to the diastereoselective syntheses of spiro[indoline-3,4'-pyridin]-2-yl carbamate derivatives.

Progressive fatigue damage analysis of composite bolted joint using equivalent stress model.

Composite bolted joints are quite necessary for composite structures connection, which has become the main limit for the use of composites in main load-bearing structures. In this article, a fatigue model of composite bolted joint based on equivalent stress is established by programming in ABAQUS USDFLD subroutine to simulate the progressive failure of composite bolted joints. By introducing three-dimensional Tsai-Hill static failure criterion, equivalent stress is calculated for investigating effects of multiaxial stress on fatigue life.

Influence of vacancy defect on surface feature and adsorption of Cs on GaN(0001) surface.

The effects of Ga and N vacancy defect on the change in surface feature, work function, and characteristic of Cs adsorption on a (2 × 2) GaN(0001) surface have been investigated using density functional theory with a plane-wave ultrasoft pseudopotential method based on first-principles calculations. The covalent bonds gain strength for Ga vacancy defect, whereas they grow weak for N vacancy defect. The lower work function is achieved for Ga and N vacancy defect surfaces than intact surface.