Printed High-Entropy Prussian Blue Analogs for Advanced Non-Volatile Memristive Devices.

Non-volatile memristors dynamically switch between high (HRS) and low resistance states (LRS) in response to electrical stimuli, essential for electronic memories, neuromorphic computing, and artificial intelligence. High-entropy Prussian blue analogs (HE-PBAs) are promising insertion-type battery materials due to their diverse composition, high structural integrity, and favorable ionic conductivity. This work proposes a non-volatile, bipolar memristor based on HE-PBA.

Hierarchical Interfacial Construction by Grafting Cellulose Nanocrystals onto Carbon Fiber for Improving the Mechanical Performance of Epoxy Composites.

Carbon fiber-reinforced composites have been widely used in the aerospace industry because of their superior comprehensive performance, including high strength, low density, fatigue resistance, long service life, etc. The interface between the fiber reinforcement and the matrix is one of the key factors that determines the performance of the composites. The construction of covalent bonding connections between the components has proven to be an effective strategy for improving the interfacial bonding strength but always reduces the toughness.

Single- to Few-Layer Nanoparticle Cathode Coating for Thiophosphate-Based All-Solid-State Batteries.

Bulk-type solid-state batteries (SSBs) composed of lithium thiophosphate superionic solid electrolytes (SEs) and high-capacity cathode active materials (CAMs) have recently attracted much attention for their potential application in next-generation electrochemical energy storage. However, compatibility issues between the key components in this kind of battery system are difficult to overcome. Here, we report on a protective cathode coating that strongly reduces the prevalence of detrimental side reactions between CAM and SE during battery operation.

Design of Ordered Mesoporous CeO-YSZ Nanocomposite Thin Films with Mixed Ionic/Electronic Conductivity via Surface Engineering.

Mixed ionic and electronic conductors represent a technologically relevant materials system for electrochemical device applications in the field of energy storage and conversion. Here, we report about the design of mixed-conducting nanocomposites by facile surface modification using atomic layer deposition (ALD). ALD is the method of choice, as it allows coating of even complex surfaces.

Ordered mesoporous metal oxides for electrochemical applications: correlation between structure, electrical properties and device performance.

Ordered mesoporous metal oxides with a high specific surface area, tailored porosity and engineered interfaces are promising materials for electrochemical applications. In particular, the method of evaporation-induced self-assembly allows the formation of nanocrystalline films of controlled thickness on polar substrates. In general, mesoporous materials have the advantage of benefiting from a unique combination of structural, chemical and physical properties.

Correlation between CYP11B2 polymorphism and the risk of preeclampsia.

Background: Many studies have evaluated the association between aldosterone synthase (CYP11B2) C-344T polymorphism and preeclampsia (PE) susceptibility, however, the results from different studies are inconsistent.

Objective: The study aimed to derive a more precise estimation of this association.

Methods: We searched PubMed, Embase, Chinese National Knowledge Infrastructure, China Biological Medicine, and Wanfang Database.

Cost-Utility Analysis of Dapagliflozin Versus Saxagliptin Treatment as Monotherapy or Combination Therapy as Add-on to Metformin for Treating Type 2 Diabetes Mellitus.

Objective: To assess the long-term cost effectiveness of dapagliflozin (DAPA) and saxagliptin (SAXA) separately or together in patients with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin (MET).

Methods: Five head-to-head randomised controlled trials of the efficacy of DAPA and SAXA in type 2 diabetes mellitus (T2DM) patients were found by searching PubMed, Embase and Cochrane from inception to October 2019. The lifetime disease progression and long-term effectiveness of therapy in patients were projected by the United Kingdom Prospective Diabetes Study Outcome Model 2 (UKPDS OM2) in three T2DM therapeutic groups: DAPA + SAXA, DAPA and SAXA.

Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.

Microglia activation-mediated neuroinflammation plays an important role in the progression of Parkinson's disease (PD). However, effects of microglia activation on dopaminergic neuronal cell (DAC) fate are still poorly understood. The objective of this study was to explore the neurotoxic effects of microglia activation-mediated oxidative injury in DACs and its possible mechanisms.

Cobalt Disulfide Nanoparticles Embedded in Porous Carbonaceous Micro-Polyhedrons Interlinked by Carbon Nanotubes for Superior Lithium and Sodium Storage.

Transition metal sulfides are appealing electrode materials for lithium and sodium batteries owing to their high theoretical capacity. However, they are commonly characterized by rather poor cycling stability and low rate capability. Herein, we investigate CoS, serving as a model compound.

Association of CD14-260 (-159) C/T and Alzheimer's disease: systematic review and trial sequential analyses.

Current studies have evaluated the association between CD14-260 (also known as -159) C/T polymorphism and Alzheimer's disease (AD) susceptibility. However, the association remains inconclusive. The aim of this study was to draw an accurate conclusion of the association.

Population pharmacokinetics of theophylline in adult Chinese patients with asthma and chronic obstructive pulmonary disease.

Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacokinetic (PPK) approaches could achieve it and many PPK studies of theophylline have been reported in infants. However, none was conducted in Chinese adults and none has explored the effect of CYP1A2 genotypes on the PPK characteristics of theophylline in adults.

Water decontamination by polyoxometalate-functionalized 3D-printed hierarchical porous devices.

The design of organic-inorganic hybrid composites has revolutionized application-driven materials design. Here, we show how hierarchically structured, 3D-printed ABS polymers can be surface-functionalized with lacunary polyoxometalate anions ([α-PWO]) featuring heavy-metal binding sites. The resulting composite is highly porous and can be used for the removal of transition-metal pollutants from water.

Remarkably Improvement in Antibacterial Activity of Carbon Nanotubes by Hybridizing with Silver Nanodots.

In view of their super capacity of adsorbing microbial, the carbon nanotubes (CNTs) were used as the carriers for in situ synthesizing well-dispersed and small-sized silver nanodots (AgND), to prepare a new type of antibacterial agent with remarkably improved activity. Polyethyleneimine (PEI) was introduced as a linkage for guaranteeing the as-generated AgND to be anchored onto the CNTs and to prevent them from agglomeration. The obtained hybridizing materials were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy, and the results showed that the AgND with an average size of 2.

Efficacy and safety of Reduqing granules in the treatment of common cold with wind-heat syndrome: a randomized, double-blind, double-dummy, positive-controlled trial.

Objective: To assess the efficacy and safety of Reduqing granules in patients with common cold with wind-heat syndrome (CCWHS).

Methods: A randomized, double-blind, double-dummy, parallel, positive- controlled trial included 72 CCWHS patients was performed. The participants were randomly assigned to two groups, Reduqing (RDQ) group and Lianhuaqingwen (LHQW) group, in a 1:1 ratio.

SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway.

Sirtuin 3 (SIRT3), a mitochondrial protein, is involved in energy metabolism, cell apoptosis and mitochondrial function. However, the role of SIRT3 in neural stem cells (NSCs) remains unknown. In previous studies, we found that microglia activation-induced cytotoxicity negatively regulated survival of NSCs, along with mitochondrial dysfunction.

Efficacy and safety of prostaglandin E1 plus lipoic acid combination therapy versus monotherapy for patients with diabetic peripheral neuropathy.

The aim of this report was to evaluate the efficacy and safety of prostaglandin E1 (PGE1) plus lipoic acid (LA) for the treatment of diabetic peripheral neuropathy (DPN) compared with that of PGE1 or LA monotherapy. Randomized controlled trials (RCT) published up to 3 August 2014 were reviewed. A random or fixed effect model was used to analyze outcomes expressed as risk ratios (RR) or mean difference (MD) with a 95% confidence interval (CI).

Signal Mechanisms of Vascular Remodeling in the Development of Pulmonary Arterial Hypertension.

Pulmonary artery hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary arterial vascular pressure. The disease severely limits the function of the right ventricle, causing organ failure and finally leading to death. Despite significant advances in pharmacological treatments, PAH remains an incurable disease with high morbidity and mortality.

Liquid-liquid interface-mediated room-temperature synthesis of amorphous NiCo pompoms from ultrathin nanosheets with high catalytic activity for hydrazine oxidation.

NixCoy alloy pompoms formed by the aggregation of nano ultrathin sheets were prepared by simultaneous reduction of NiCl2 and CoCl2 with NaBH4via a liquid-liquid interface reaction. Ni1Co3 pompoms produced markedly higher activity and stability as hydrazine oxidation catalysts than Ni, Co and other NixCoy pompom catalysts.

Evolution of nanoscale amorphous, crystalline and phase-segregated PtNiP nanoparticles and their electrocatalytic effect on methanol oxidation reaction.

The design of amorphous noble metallic nanoparticle electrocatalysts is an important fundamental and applied research challenge because their surface is rich in low-coordination sites and defects which could act as the active sites in various catalytic processes. Here we describe new findings on the amorphous platinum-nickel-phosphorous nanoparticles supported on carbon black (PtNiP(a)/C) and the comparison between their catalytic activity and that of the nanoscale crystalline and phase-segregated PtNiP nanoparticles. The nanoscale amorphous, crystalline and phase-segregated catalysts were probed as a function of surface composition, particle size, and thermal treatment conditions using X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, selected area electron diffraction and electrochemical characterization.

Synthesis of carbon-supported PdSn-SnO2 nanoparticles with different degrees of interfacial contact and enhanced catalytic activities for formic acid oxidation.

The conjunction of the PdSn alloy and SnO2 is of interest for improving catalytic activity in formic acid oxidation (FAO). Here, we report the synthesis of PdSn-SnO2 nanoparticles and a study of their catalytic FAO activity. Different degrees of interfacial contact between SnO2 and PdSn were obtained using two different stabilizers (sodium citrate and EDTA) during the reduction process in catalyst preparation.