Publications by authors named "Yanjiao Li"

On 30 January 2024, China announced the first human case of H10N5 influenza infection. Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution and future epidemiological trends of the H10 and N5 subtypes of avian influenza viruses (AIVs).

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Renal interstitial fibrosis, a condition prevalent in aging humans and animals, is closely linked to the eventual development of renal failure. Establishing an animal model that exactly replicates the pathogenesis of renal interstitial fibrosis induced by natural aging in humans is crucial for advancing mechanistic studies and testing antifibrotic therapies. Implanted allogeneic or xenogeneic cells are cleared by the immune system when stem cell therapy is applied in nonimmunodeficient animal fibrosis models, affecting the effect of the intervention and making it difficult to demonstrate the survival, proliferation, differentiation, or secretion of the delivered autologous human-derived cells.

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  • This study investigates the relationship between certain gene expressions in the dentate gyrus (DG) of the brain and different types of memory, specifically fear memory and reward memory.
  • It was found that expression levels increased after inducing fear memory compared to reward memory, indicating a potential link between these expressions and memory types.
  • Additionally, artificially boosting the expression in the DG enhanced reward memory, suggesting that it plays a significant role in how we process rewards.
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The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial establishment of lung cancer organoids (LCOs), and timely therapeutic recommendations face several challenges. Particularly, the current culture systems have not yet achieved the capability to long-term cultivation of all lung tumor sample sources, including malignant pleural effusion (MPE), which poses significant barriers to the rapid clinical translation of PDOs.

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Alzheimer's disease (AD) poses a significant health challenge worldwide, and the development of effective treatments necessitates a comprehensive understanding of its pathophysiology. Mouse models have been instrumental in offering insights into the crucial pathogenesis of AD. However, current models rarely recapitulate all aspects of AD pathology in patients; thus, translating the findings from mouse to human clinical trials has proved to be complex.

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  • Peanuts are a vital source of vegetable oils and proteins, but understanding how their oil and protein contents are regulated is still a challenge.
  • Researchers analyzed peanut seeds from two different varieties, "YH15" (high in oil) and "KB008" (high in protein), at four developmental stages using metabolomics and transcriptome analysis.
  • They discovered 984 differential metabolites and identified key gene modules linked to the differences in oil and protein contents, providing insights for future peanut variety cultivation with improved nutritional value.
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The objective of this study was to evaluate the effects of different concentrations of hydrogen-rich water (HRW) on in vitro rumen fermentation characteristics and the dynamics of bacterial communities. The experiment included four treatment groups: a control (CON) and hydrogen-rich water (HRW) at 200, 400, and 800 ppb. Each group was analyzed at 12-hour (h) and 48-hour (h) time points with five replicates, totaling 40 samples.

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The purpose of this study is to explore the carcass traits, meat quality, and nutritional attributes of local yellow cattle (Guangfeng, Ji'an, and Jinjiang) and buffalo (Poyanghu, Xiajiang, and Xinfeng mountain) in Jiangxi Province, and compare the differences among different breeds. The results showed that the dressing percentage, net meat percentage, and meat-bone ratio of Jinjiang cattle were highest, and that Jinjiang cattle had the best meat production performance. Regarding meat quality, the pH value of all breeds was at normal level, and no dark-cutting beef was produced.

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Metal selenides are very promising anode materials for sodium ion batteries (SIBs) due to their rich redox behaviors, low cost, high theoretical capacity, and environmentally benign. However, the poor cycle performance and rate capability greatly hinder their widespread applications. In this paper, we have proposed a tannic acid etching zeolitic imidazolate framework-67 (ZIF-67)-derived selenide strategy to construct hollow heterogeneous CoSe-FeSe@N-doped carbon rhombic dodecahedron (CoSe-FeSe@NC) as anode for high-performance SIBs.

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  • Osteoporosis primarily impacts older individuals, and this study explored using immunodeficient NOD/SCID mice to create a more effective human osteoporosis model without premature immune rejection of transplanted cells.
  • Mice of varying ages (12, 32, and 43 weeks) were studied, revealing that older mice had significant bone density loss and changes in bone structure, indicating increased osteoporosis severity.
  • The research also showed shifts in gene expression related to bone metabolism and aging, such as decreased osteogenic gene expression and heightened inflammatory markers as mice aged, highlighting the complex biological changes that occur in osteoporosis.
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essential oil (PEO), extracted from , has anti-oxidant, anti-inflammatory, and anti-stress properties, as well as the ability to improve gastrointestinal digestion. This study aims to evaluate the effects of PEO on the performance, rumen epithelial morphology, and barrier function in heat-stressed beef cattle. Thirty-six male Jingjiang cattle at 18 months old were randomly assigned into four groups and fed a diet containing PEO at 0 (control), 50, 100, or 150 mg/kg in the feed concentrate ( = 9).

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Background: Idiopathic pulmonary fibrosis (IPF) is an age-related disease severely affecting life quality with its prevalence rising as the population ages, yet there is still no effective treatment available. Cell therapy has emerged as a promising option for IPF, however, the absence of mature and stable animal models for IPF immunodeficiency hampers preclinical evaluations of human cell therapies, primarily due to rapid immune clearance of administered cells. This study aims to establish a reliable pulmonary fibrosis (PF) model in immunodeficient mice that supports autologous cell therapy and to investigate underlying mechanism.

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The emission of microplastics and heavy metals in landfills has attracted widespread attention for its stabilization process. Microplastics have become carriers of heavy metals due to their adsorption properties, affecting their environmental behavior. However, the effects of landfill stabilization on the interaction between microplastics and heavy metals in leachate are ambiguous.

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The L-type Ca channel (LTCC, also known as Cav1,2) is involved in the regulation of key neuronal functions, such as dendritic information integration, cell survival, and neuronal gene expression. Clinical studies have shown an association between L-type calcium channels and the onset of depression, although the precise mechanisms remain unclear. The development of depression results from a combination of environmental and genetic factors.

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Objective: To explore the mechanism by which Tongqiao Yizhi granule (, TQYZKL) intervenes pyroptosis to treat vascular dementia (VaD) in a rat model.

Methods: The rat model of VaD was established by two-vessel occlusion (2VO). The rats were randomly divided into Sham group, Model group, Nimodipine group, TQYZKL (6.

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Slightly acidic electrolyzed water (SAEW) is a safe and effective disinfectant, but its sterilizing efficiency is compromised by organic matter on the egg surface. Electrolyzed reduced water (ERW) is a harmless cleaner with a decontamination effect on a variety of surfaces and can be used to remove organic matter. This study assesses the effectiveness of a combination of ERW and SAEW in eliminating Salmonella and manure mixture from egg surfaces, as well as its impact on egg quality during storage.

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Sirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the involvement of sirtuins in tumor biology has garnered substantial attention, with a growing body of evidence underscoring their regulatory roles in various aberrant cellular processes within tumor environments. This article delves into the sirtuin family and its biological functions, shedding light on their dual roles-either as promoters or inhibitors-in various cancers including oral, breast, hepatocellular, lung, and gastric cancers.

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  • Non-small cell lung cancer (NSCLC) features significant genetic variations, making it crucial to identify key genes and pathways for better diagnosis and treatment outcomes.
  • The study analyzed over 93,000 cells from 22 NSCLC patients using advanced techniques to classify cancer cells and understand gene expression changes throughout the development of the disease.
  • Key findings included three functional modules of NSCLC cells, highlighting the importance of metabolism, cell cycle, and stemness in cancer progression, and establishing a risk score model based on specific genes that can aid in cancer risk assessment and personalized treatment.
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Early onset familial Alzheimer's disease (FAD) with APP, PS1/2 (presenilins) mutation accounts for only a small portion of AD cases, and most are late-onset sporadic. However, majority of AD mouse models are developed to mimic the genetic cause of human AD by overexpressing mutated forms of human APP, PS1/2, and/or Tau protein, though there is no Tau mutation in AD, and no single mouse model recapitulates all aspects of AD pathology. Here, we report Thy1-ApoE4/C/EBPβ double transgenic mouse model that demonstrates key AD pathologies in an age-dependent manner in absence of any human APP or PS1/2 mutation.

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Landfills remain the predominant means of solid waste management worldwide. Widespread distribution and significant stockpiles of waste in landfills make them a significant source of methane emissions, exacerbating climate change. Anaerobic oxidation of methane (AOM) has been shown to play a critical role in mitigating methane emissions on a global scale.

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Widespread landfills represent a significant source of groundwater contamination. Due to the unique and diverse nature of dissolved organic matter (DOM) in landfill leachate, the interaction between DOM and heavy metals, along with its quantitative evaluation, remains unknown. Consequently, we collected ten samples from various landfill types to serve as representatives for a comprehensive investigation of the mechanism involving functional groups and Cr(III) through the establishment of a quantitative structure-activity relationship (QSAR).

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The challenge of wheat straw as a ruminant feed is its low ruminal digestibility. This study investigated the impact of a xylanase called RuXyn, derived from the rumen metagenome of beef cattle, on the in vitro ruminal fermentation of wheat straw. RuXyn encoded 505 amino acids and was categorized within subfamily 8 of the glycosyl hydrolase 30 family.

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Liver fibrosis, a critical pathological feature of chronic liver diseases, arises from a multitude of pathogenic factors. Consequently, establishing an appropriate animal model to simulate liver fibrosis holds immense significance for comprehending its underlying pathogenesis. Despite the numerous methodologies available for generating liver fibrosis models, they often deviate substantially from the spontaneous age-related liver fibrosis process.

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Alzheimer's disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical symptom. However, there is no disease-modifying small molecular medicine to effectively slow down progression of the disease. Here, we show an optimized asparagine endopeptidase (AEP, also known as δ-secretase) inhibitor, #11 A, that displays an orderly in vivo pharmacokinetics/pharmacodynamics (PK/PD) relationship and robustly attenuates AD pathologies in a sporadic AD mouse model.

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Synopsis of recent research by authors named "Yanjiao Li"

  • - Yanjiao Li's research primarily focuses on innovative applications in health and environmental sciences, particularly exploring materials for battery technology, understanding disease dynamics in animal reservoirs, and developing animal models for aging-related conditions.
  • - Recent studies include the construction of novel electrode materials for sodium ion batteries using tannic acid etching, the identification of sentinel species for COVID-19 monitoring, and the establishment of advanced models for osteoporosis and pulmonary fibrosis in immunocompromised mice.
  • - Li's work also investigates interactions between microplastics and heavy metals in landfills, contributions of specific substances in mitigating depressive behaviors in mice, and the effects of traditional herbal remedies on neurological conditions in rats, highlighting a multidisciplinary approach to health and environmental challenges.