Asthma research in mice: An overview of current models and their methodological variability.

Studies in murine experimental models have made significant contributions to the understanding of asthma pathophysiology and the discovery of innovative therapeutic approaches. Nonetheless, there is a plethora of options available for selecting mouse strains, sensitization methods, challenge routes and doses, as well as approaches to evaluating host response in murine asthma model protocols. Due to the diversity of models employed, comparing results across different studies proves exceedingly challenging.

Clara cell 10 (CC10) protein attenuates allergic airway inflammation by modulating lung dendritic cell functions.

Allergic asthma is a complex inflammatory disorder predominantly orchestrated by T helper 2 (Th2) lymphocytes. The anti-inflammatory protein Clara Cell 10-kDa (CC10), also known as secretoglobin family 1A member 1 (SCGB1A1), shows promise in modulating respiratory diseases. However, its precise role in asthma remains unclear.

Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.

Background: The dosage of ovalbumin (OVA) during the sensitization stage is considered a crucial factor in the development of airway hyperresponsiveness (AHR). However, the inconsistent dosages of sensitizing OVA used in current studies and the lack of research on their impact on AHR are notable limitations.

Methods: We examined the impact of increasing sensitizing doses of OVA in a murine asthma model, which entailed initial sensitization with OVA followed by repeated exposure to OVA aerosols.

Efficacy of five-step shoulder manipulation for rotator cuff-related shoulder pain: protocol for a multicenter randomized controlled trial.

Background: Rotator cuff-related shoulder pain (RCRSP) is the most common cause of shoulder disorders. In China, manipulation has been used extensively for the treatment of patients with RCRSP. However, high-quality clinical evidence to support the therapeutic effect of manipulation is still limited.

Undiagnosed Long COVID-19 in China Among Non-vaccinated Individuals: Identifying Persistent Symptoms and Impacts on Patients' Health-Related Quality of Life.

Is Long COVID-19 under-diagnosed? The definition of this new condition has received many contributions, and it is still under development as a great variety of symptoms have been associated to it. This study explores the possibility that there are non-diagnosed cases among individuals who have been infected by SARS-CoV-2 and have not been vaccinated. The long-term symptoms identified among a sample 255 individuals have been associated to Long COVID-19 by recent literature.

Is there a gap between artificial intelligence applications and priorities in health care and nursing management?

Aim: The article aims to outline a contrast between three priorities for nursing management proposed a decade ago and key features of the following 10 years of developments on artificial intelligence for health care and nursing management. This analysis intends to contribute to update the international debate on bridging the essence of health care and nursing management priorities and the focus of artificial intelligence developers.

Background: Artificial intelligence research promises innovative approaches to supporting nurses' clinical decision-making and to conduct tasks not related to patient interaction, including administrative activities and patient records.

Research hotspot and frontier analysis of traditional Chinese medicine in asthma using bibliometric methods from 1991 to 2021.

Traditional Chinese medicine (TCM) has been successfully used to treat asthmatic conditions for centuries. Nevertheless, the current hotspots and research frontiers on TCM for asthma have not been systematically investigated on the basis of bibliometric analysis. In this study, a scientometric analysis (1991-2021) was carried out on 3081 journal articles obtained from the Web of Science Core Collection database to explore the basic characteristics, research hotspots, and frontiers of TCM in asthma research.

Electroacupuncture at ST36 () Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice.

Purpose: Sepsis is the main cause of death in intensive care unit. Maladaptive cytokine storm and T-cell lymphopenia are critical prognosis predictors of sepsis. Electroacupuncture (EA) is expected to be an effective intervention to prevent sepsis.

Carboxylation of sodium arylsulfinates with CO over mesoporous K-Cu-20TiO.

A mesoporous ternary metal oxide (K-Cu-20TiO) from a simple sol-gel method was prepared to catalyze heterogeneously the carboxylation reaction of various sodium arylsulfinates under atmospheric carbon dioxide. The catalyst showed excellent selectivity and good functional group tolerance to carboxylation recycle. The oxidation state of active copper(i) by characterization using FTIR, XRD, TG, XPS and TEM techniques proved to be efficacious to conduct atom economical reactions.

Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness.

Objective: S100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory activities. We previously reported that S100A11 was differentially expressed in the respiratory tracts of asthmatic rats as compared with normal controls. Here, we aimed to analyze the potential of S100A11 to regulate both allergen-induced airway hyperresponsiveness (AHR) as well as acetylcholine (ACh)-induced hypercontractility of airway smooth muscle (ASM) and contraction of ASM cells (ASMCs).

[Research progress of lung natural killer cells and their roles in pulmonary diseases].

Lung natural killer (NK) cells can be classified into tissue-resident NK (trNK) cells and conventional NK (cNK) cells. Both trNK and cNK are composed of multiple subsets with unique phenotypes and functional characteristics. However, the phenotypic and functional differences between the two captured less attention.

A Simulation Analyzing Approach to Estimating the Probability of Airborne Infection Risks in Railway Station Platform Coupling with the Wells-Riley Model and Pathfinder Model.

Railway station platforms present a particular challenge, especially during a train departure or arrival where some passengers may have potential conditions that make them vulnerable to airborne infections due to the high density and close proximity of passengers. This study presented a simulation analyzing approach to estimating the probability of airborne infection risks in station platform spaces coupling with the Wells-Riley model and Pathfinder model. We examine the impact of overcrowded area of the station platform on infection rates under various traces of evacuation.

Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.

Purpose: Cyclophilin A (CypA) inhibits CD4 T cell signal transduction via interleukin-2-inducible T-cell kinase (Itk), a tyrosine kinase required for T helper (Th) 2 cells function. Furthermore, mice with CypA silencing developed allergic diseases associated with increased Th2 cytokines production. CD4 T cells with a Th2-cytokine pattern have been demonstrated to have a pivotal role in the pathogenesis of asthma.

Acupuncture in a Rat Model of Asthma.

A high platform can fix rats without restriction and completely expose the acupoints on the back during acupuncture manipulation. This article describes methods for the fabrication of the high platform, establishes a rat model of asthma and measures changes in respiratory function using a noninvasive and real-time whole-body plethysmography (WBP) system.

Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas.

Ethnopharmacological Relevance: Standard therapy for asthma, a highly heterogeneous disease, is primarily based on bronchodilators and immunosuppressive drugs, which confer short-term symptomatic relief but not a cure. It is difficult to discover novel bronchodilators, although potential new targets are emerging. Traditional Chinese Medicine (TCM) formulas have been used to treat asthma for more than 2000 years, forming the basis for representative asthma treatments.

Classic Chinese Acupuncture versus Different Types of Control Groups for the Treatment of Chronic Pain: Review of Randomized Controlled Trials (2000-2018).

Objective: To review the effectiveness of classic Chinese acupuncture in the treatment of chronic pain by comparing treatment groups with different types of control groups in accordance with the newly published guidelines for systematic reviews.

Methods: We searched EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials databases from 2000 to 2018. We included randomized controlled trials that included acupuncture as the sole treatment or as an adjunctive treatment for chronic pain.

Burden of typical diseases attributed to the sources of PM-bound toxic metals in Beijing: An integrated approach to source apportionment and QALYs.

PM-bound toxic metals (TMs) are derived from various sources, and they can cause many adverse health effects on the human body. To effectively reduce the disease burden of TMs by controlling the relative sources, an integrated approach of quality-adjusted life years (QALYs) and source-apportionment (positive matrix factorization, PMF) was proposed and applied to some typical diseases induced by TMs in 2017 in Beijing. The estimation included two parts; first, the number of potentially affected people was calculated based on the source mass contribution from PMF and the inhalation unit risk of TMs; second, the QALYs lost per affected person was calculated based on the disease duration, expected years of life lost (EYLL) and quality of life (QoL) for both affected people and the general population.

What Is the Appropriate Acupuncture Treatment Schedule for Chronic Pain? Review and Analysis of Randomized Controlled Trials.

Background: Acupuncture is widely used for the treatment of chronic pain. Different protocols of acupuncture practice exist and lack agreement on the optimal schedule of acupuncture treatment.

Objective: To review the appropriate acupuncture treatment schedule for chronic pain.

Implications of seasonal control of PM-bound PAHs: An integrated approach for source apportionment, source region identification and health risk assessment.

PM-bound PAHs are ubiquitous in urban atmospheres and are characterized as carcinogenic, teratogenic and mutagenic upon inhalation. A total of 218 daily PM samples were collected during one year in the urban district of Beijing, China. Analysis showed that the annual mean concentration of total PAHs (TPAHs) was 66.

Levels and health risks of PM-bound toxic metals from firework/firecracker burning during festival periods in response to management strategies.

Daily PM was collected in the periods before, during and after the Chinese Spring Festival (CSF) in both 2016 and 2018 to clarify the annual variation in the concentrations and health risks of toxic metals under different firework/firecracker (FF) management strategies. PM and bound metals all decreased during the CSF from 2016 to 2018. According to relative abundance analysis, toxic metals, i.

Copper-Catalyzed Regioselective and Stereoselective Coupling of Grignard Reagents with Pent-1-en-4-yn-3-yl Benzoates: A Shortcut to ( Z) -1,5-Disubstituted Pent-3-en-1-ynes from Accessible Starting Materials.

Copper-catalyzed coupling of Grignard reagents with pent-1-en-4-yn-3-yl benzoates occurs regioselectively at the terminal alkenyl carbon rather than the alkynyl site, leading to the stereoselective formation of unexpected ( Z) -1,5-disubstituted pent-3-en-1-ynes without generation of the initially expected alkenyl allene products. By using easily accessible starting materials, this reaction can provide direct access to thermodynamically unfavorable Z-configured enynes, which widely exist in many bioactive natural products, such as the anti-inflammatory components in henna.

Impacts of silicon addition on arsenic fractionation in soils and arsenic speciation in Panax notoginseng planted in soils contaminated with high levels of arsenic.

Arsenic (As) is a well-known carcinogenic substance whose biological toxicity in soils and plants depends on its concentration and chemical forms. Silicon (Si) generally can alleviate biotic and abiotic stresses, including As stress. However, its effects vary depending on As chemical form, plant species and other factors.

Emission control priority of PM-bound heavy metals in different seasons: A comprehensive analysis from health risk perspective.

Source-specific health risks of PM-bound metals were analyzed for emission control by integrating source apportionment with health risk assessments of residents affected via inhalation pathways. A total of 218 daily PM samples were collected in 2016 in the central urban district of Beijing, China. Analyses showed that the mean annual concentrations of total heavy metals (THMs) and PM were 0.

Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus.

The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed.

Comparison on the effects of water-borne and dietary-borne accumulated ZnO nanoparticles on Daphnia magna.

Nanoparticles (NPs) can exert toxicity to aquatic animals through water and dietary exposure. However, little is known about the contribution of the two exposure pathways to the total toxicity of NPs to aquatic animals. In the present study, we fed Daphnia magna with ZnO NPs-accumulated-algae or directly exposed them to ZnO NPs suspension at the same Zn concentration.