Publications by authors named "Yanjiang Yin"
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.
Signal Transduct Target Ther
September 2024
Article Synopsis
- Liver metastasis is the leading cause of death in colon cancer patients, and identifying gene mutations involved in this process may provide new treatment targets.
- Researchers conducted a detailed analysis of cancer cells from a stage IV colon cancer patient, revealing that both liver and lymphatic metastases originated from the primary tumor but with greater genetic diversity than the primary tumor itself.
- The study highlights a specific mutation in the TRPS1 gene that increases cancer cell invasion and suggests that liver metastases often arise from multiple tumor cell clusters rather than a single cell, indicating a more complex mechanism of metastasis progression.
Background: The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma.
Methods: The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of miR-380. The Cell Counting Kit 8 assay, flow cytometry, and Transwell assay were used to detect the effects of miR-380 and LIS1 on the proliferation, S-phase ratio, and invasiveness of HCCC-9810/HuCCT1/QBC939 cells.
The degradation of visual quality in remote sensing images caused by haze presents significant challenges in interpreting and extracting essential information. To effectively mitigate the impact of haze on image quality, we propose an unsupervised generative adversarial network specifically designed for remote sensing image dehazing. This network includes two generators with identical structures and two discriminators with identical structures.
View Article and Find Full Text PDFThe enhancer of zeste homolog 2 (EZH2) is a methylated modification enzyme of Histone H3-Lys 27. The high expression of EZH2 in cells is closely related to the progression, invasion, and metastasis of neoplasm. Therefore, this target is gradually becoming one of the research hot spots of tumor pathogenesis, and the inhibitors of the EZH2 enzyme are expected to become new antitumor drugs.
View Article and Find Full Text PDFObjectives: This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.
Methods: Gene expression profiles from GSE12865, GSE14359, GSE33382, GSE36001 and GSE99671 were obtained respectively from GEO database. Differentially expressed genes were identified, and functional enrichment analysis, such as GO, KEGG, GSEA, PPI were performed to make a comprehensive understanding of the hub genes.