Publications by authors named "Yaniv Swiel"
Background: Genetic variation in the non-recombining part of the human Y chromosome has provided important insight into the paternal history of human populations. However, a significant and yet unexplained branch length variation of Y chromosome lineages has been observed, notably amongst those that are highly diverged from the human reference Y chromosome. Understanding the origin of this variation, which has previously been attributed to changes in generation time, mutation rate, or efficacy of selection, is important for accurately reconstructing human evolutionary and demographic history.
View Article and Find Full Text PDFArticle Synopsis
- Esophageal squamous cell carcinoma (ESCC) is prevalent in sub-Saharan Africa, but there have been no extensive genetic studies focusing on African populations, despite significant findings in East Asian groups.
- A genome-wide association study (GWAS) involving 1,686 African ESCC patients and 3,217 matched controls identified a significant risk locus near the FAM120A gene on chromosome 9 and a potential African-specific risk locus on chromosome 2 (MYO1B).
- A meta-analysis combining African and Chinese data revealed shared and unique genetic risk factors for ESCC, highlighting the important genetic contributions to the disease in African populations.