Publications by authors named "Yanis Toledano"
Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi.
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- The scorpion toxin tamapin is the most effective blocker of KCa2.2 channels, with this study examining its creation, structure, and cancer cell toxicity.
- Researchers tested tamapin and five mutated versions on Jurkat T and breast cancer cells, finding that tamapin and its variants caused cell death in a dose- and time-dependent manner.
- Structural analysis showed that tamapin maintains its shape despite mutations, while changes in toxicity suggest the importance of specific amino acids in interacting with KCa2.2 channels to induce cell death.