Autologous platelet-poor plasma decreases the bronchial stump necrosis in rat.

Background: Necrosis of the bronchial stump is a very important trigger for bronchopleural fistula. The administration of local autologous platelet-poor plasma (PPP) could protect the bronchial stump.

Materials And Methods: Left pneumonectomy was performed in 25 Sprague-Dawley rats.

Technical modifications of the orthotopic lung transplantation model in rats with brain-dead donors.

Background: Microsurgical lung transplantation in rats has allowed us to obtain new knowledge about lung transplantation. However, some aspects in human transplantation technique still have not been included in this model, which could interfere with the clinical interpretation and extrapolation of results.

Methods: Twenty left lung transplantations were performed with a cuff technique and technical modifications, such as brain death induction, the control of ischemia time and retrograde perfusion in the donor and the controlled sequential reperfusion of the implanted lung in the recipient.