Publications by authors named "Yanik Deana"
The Tcf21 lineage constitutes the lung lipofibroblast population.
Am J Physiol Lung Cell Mol Physiol
May 2019
Article Synopsis
- Tcf21 is a crucial transcription factor for mesenchymal development in various organs, particularly in embryonic lung mesenchyme, where its absence leads to underdeveloped lungs.
- Researchers tracked Tcf21-expressing cells from embryonic stages to adulthood, discovering that Tcf21 progenitor cells differentiate into specific cell types, including lipofibroblasts and interstitial fibroblasts after embryonic day 15.5.
- Elevated expression of lipid metabolism genes in Tcf21 lineage cells and the effect of Tcf21 overexpression on lipid accumulation suggests that Tcf21 plays a significant role in regulating lipofibroblast functions.
Purpose: Ionizing radiation is nowadays effectively used in cancer treatments. However, the effect of irradiation in immune-system cells is poorly understood and remains controversial. The aim of this work was to determine the effect of γ-irradiation in the structural and functional properties of mice splenic cells.
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