A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2-ARE Inhibiting Ferroptosis in Dopaminergic Neurons.

Background: The pathology of Parkinson's disease (PD) indicates that iron deposition exists in dopaminergic neurons, which may be related to the death of cellular lipid iron peroxide. The extracellular autophagy adaptor SQSTM1(p62) of dopamine (DA) neurons can activate the intracellular Keap1-Nrf2-ARE signaling pathway to inhibit ferroptosis, which has a protective effect on DA neurons.

Objective: The objective of this study was to investigate the protective mechanism of the Keap1-Nrf2-ARE antioxidant pathway against iron death in dopaminergic neurons.

[Related factors and prevalence for the essential tremor disease of Uygur residents in Hetian, Xinjiang UygurAutonomous Region].

Objective: To explore the prevalence and related factors of essential tremor (ET) in permanent residents of Hetian, Xinjiang.

Methods: By cluster random sampling, the local residents ( ≥ 10 years) at the age of 45 years and above in Hetian, Xinjiang received an epidemiological survey covering 1 city and 7 counties. Hetian City, Yutian County, Moyu County and Luopu County were randomly selected.

T313M polymorphism of the PINK1 gene in Parkinson's disease.

The present study aimed to investigate the association between T313M polymorphism at exon 4 of the PTEN-induced putative kinase 1 (PINK1) gene and Parkinson's disease (PD) in the Uygur and Han populations of Xinjiang, China. Genetic DNA was extracted from 364 patients with PD from the Uygur and Han populations, as well as 346 normal control patients. Four exons of the PINK1 gene were amplified using quantitative polymerase chain reaction.

Correlation between LRRK2 gene G2385R polymorphisms and Parkinson's disease.

The aim of the current study was to determine the correlation between the G2385R polymorphism of the LRRK2 gene and Parkinson's disease (PD) and the differences in genotypic and allelic frequencies between the Uyghur and Han Chinese populations. A case-control study was performed in which the genotypic and allelic frequencies of the LRRK2 gene G2385R polymorphism were analyzed using a polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. Results showed the frequency of the GG genotype to be the highest, whereas that of the GA-type heterozygote was the lowest.