Publications by authors named "Yanhui Li"

Developing antimicrobial therapies not rely on antibiotics is an expective way to resolve the threat of drug-resistant bacteria, such as photodynamic antimicrobial therapy (APDT). However, the main antibacterial species in APDT are reactive oxygen species (ROS), and the overproduction of ROS will cause serious inflammatory and delay wound healing. Therefore, it is necessary to solve this contradiction in order to realize anti-inflammatory in the process of APDT.

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Background: Bilateral 3-portal endoscopy is a novel minimally decompression surgery based on the modification of unilateral biportal endoscopy, which achieves complete decompression through a bilateral approach for patients with lumbar spinal stenosis. This study tested the hypothesis that bilateral 3-portal endoscopy could improve clinical outcomes and satisfaction versus unilateral biportal endoscopy in these patients.

Methods: In this multicenter, retrospective, cohort study, 87 patients with lumbar spinal stenosis who received bilateral 3-portal endoscopy or unilateral biportal endoscopy were divided into bilateral 3-portal endoscopy (N = 35) and unilateral biportal endoscopy (N = 52) groups, respectively.

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Purpose: Endometriosis is a common chronic neuroinflammatory disease with a poorly understood pathogenesis. Molecular changes and specific immune cell infiltration in the eutopic endometrium are critical to disease progression. This study aims to explore immune mechanisms and molecular differences in the proliferative eutopic endometrium of endometriosis by integrating bulk RNA-seq and single-cell RNA sequencing (scRNA-seq) data, and to develop diagnostic and predictive models for the disease.

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Dye pollution is a significant global environmental issue. To address this problem, various adsorbents have been employed, but traditional adsorbents often suffer from poor reusability and limited adsorption efficiency. Metal-organic frameworks (MOFs), which have emerged in recent years, have excellent physicochemical properties, but their application in wastewater treatment is limited by their polycrystalline, powdered state.

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Neuropathic pain is a worldwide problem that causes physical and psychological pain to many patients. 3-acetylaconitine (AAC) is a kind of non-narcotic analgesic with long-lasting action, non-tolerant and non-addiction. However, it has some cardiac toxicity and can easily cause toxic organ damage.

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A MOF-based dye adsorbent, sodium alginate@silica@UiO-67 (SA@SiO@UiO-67) aerogel beads, was prepared by hydrothermal method using sodium alginate@silica (SA@SiO) as the carrier and zirconium organic skeleton as the nanocrystals for the in-situ growth of MOF multi-sites. The properties of the composite aerogel beads were investigated using SEM, XRD, TGA, FT-IR, BET and zeta potential tests. Langmuir simulation revealed that the composite aerogel beads achieved a maximum methylene blue removal capacity of 1094.

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Developing multifunctional photocatalysts with intelligent self-adjusting is of great significance in the photocatalytic process. Herein, a smart covalent organic framework (Por-HQ-COF) with a phenol-quinone conversion structure with pH changes is constructed for photooxidation, photoreduction, and HO production. As a smart photocatalyst, Por-HQ-COF can convert into Por-BQ-COF intelligently with a trigger including solution pH, and vice versa.

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Objective: This study aimed to explore whether cavitation generated by ultrasound-stimulated microbubbles (USMB) can enhance the therapeutic efficacy of colchicine and diminish its gastrointestinal side effects in rats with acute gouty arthritis (AGA).

Materials And Methods: The rat AGA model was established by injection of Monosodium urate (MSU) crystals. The rats were randomly divided into 6 groups (A: control group, B: model control group, C: cavitation group, D: high dose colchicine group, E: cavitation + low dose colchicine group, F: cavitation + high dose colchicine group) according to whether they were given cavitation and different doses of colchicine.

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Hepatic lipotoxicity, resulting from excessive lipid accumulation in hepatocytes, plays a central role in the pathogenesis of various metabolic liver diseases. Despite recent progress, the precise mechanisms remain incompletely understood. Using excessive exposure to palmitate in hepatocytes as our primary experimental model and mice studies, we aimed to uncover the mechanisms behind hepatic lipotoxicity, thereby developing potential treatments.

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Introduction: Despite increasing awareness on the prevention of Ureaplasma urealyticum (Uu) infection, the high-risk factors responsible for infection in female patients in China are yet to be determined.

Methodology: The study included 3043 Chinese women. Cervical secretion samples were collected for Uu identification.

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Culm strength is crucial for rice growth, nutrition transportation, and structural resilience, which are essential for lodging resistance and stable production. In this study, we identified a rice thin culm mutant tc4, characterized by thinner culms and thicker cavity walls, resulting in weakened culm mechanical strength. Using map-based cloning, the candidate gene was isolated, and complementation and CRISPR/Cas9 experiments confirmed that a single nucleotide substitution in TC4 is responsible for the thin and brittle culm phenotype.

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To investigate the efficacy and mechanisms of fractional CO2 laser treatment for Vaginal Relaxation Syndrome (VRS) combined with recurrent bacterial vaginitis. Patients with VRS and recurrent bacterial vaginitis were randomly assigned to an intervention group (n = 60) receiving fractional CO2 laser therapy in addition to metronidazole, or a control group (n = 60) receiving metronidazole alone. Post-treatment assessments included vaginal relaxation, vaginal health index (VHI) scores, lactobacilli distribution, vaginal pH, recurrence rates, and the correlation between lactobacilli distribution and VHI.

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Article Synopsis
  • Ankylosing spondylitis (AS) is a chronic condition characterized by inflammation of the spine and sacroiliac joints, leading to potential delays in diagnosis and treatment due to its non-specific early symptoms, underscoring the need for new biomarkers.
  • Two datasets (GSE73754 and GSE25101) were analyzed to identify key genes related to AS, using methods like differential expression analysis and LASSO regression, which resulted in the discovery of five significant genes (ACSL1, SLC40A1, GZMM, TRIB1, XBP1) that showed strong diagnostic potential.
  • The study also revealed correlations between these genes and immune cell infiltration as well as clinical indicators, with notable links between
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Background: Nitrogen (N) deposition has become a major driving factor affecting the balance of terrestrial ecosystems, changing the soil environment, element balance and species coexistence relationships, driving changes in biodiversity and ecosystem structure and function. Human-induced nitrogen input leads to a high NH/ NO ratio in soil. However, relatively few studies have investigated the effects of different nitrogen sources on forest plant-microbial symbionts.

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Background: To investigate the joint associations between various body fat distribution parameters and high blood pressure (HBP) using the Bayesian Kernel Machine Regression (BKMR) model in school-aged children.

Methods: A diverse sample of 7 ∼ 17 years old (N = 1423; 50.25% boys) was recruited for this study.

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Background: Caffeine has been suggested to have a relationship with endometriosis as a widely consumed psychoactive substance, although findings are inconsistent.

Objective: This study explored the potential associations and threshold effects between caffeine intake and endometriosis using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006.

Methods: The study included 248 women with endometriosis and 2944 without, aged 20-50 years.

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Article Synopsis
  • * Researchers identified 21 human ITPR1 GOF variants and created a mouse model with one of these variants (ITPR1-W1457G), which was found to be prone to stress-induced ventricular arrhythmias.
  • * Both mouse models and human data suggest that ITPR1 GOF variants increase Ca handling abnormalities and arrhythmia risk, with 7 rare ITPR1 variants in a human database showing similar GOF behavior linked to cardiac
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High entropy alloys (HEAs) are promising heterocatalysts because of their unique physicochemical properties, but research on HEA-catalyzed tandem reactions is lacking. Moreover, limited research on HEAs for molecular transformation has hindered their development. Herein, an unsupported nanoporous HEA Al-Pt-Pd-Ru (HEANPore) prepared using a top-down dealloying method is reported.

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Background And Aims: Ischemic heart disease (IHD) presents a significant global health challenge, with myocardial ischemia-reperfusion injury (MIRI) being a major pathophysiological contributor and lacking effective interventions. While aerobic exercise training (AET) enhances cardiovascular health, its protective mechanism in MIRI remains elusive. This study aims to elucidate the protective effect of AET in MIRI and its underlying mechanism.

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Background: Metastasis of malignant tumors to the cardiac endocardium is rare and mainly involves the right side of the heart. It is extremely rare to involve the left cardiac endocardium, especially when there is neither pulmonary metastasis nor primary lung cancer, which we call "isolated" left cardiac endocardium metastasis in this paper. Few such cases previously reported in the literature were not screened for patent foramen ovale (PFO).

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Background: According to recent research, there is a considerable correlation between the severity of coronary artery disease and the platelet-to-high-density lipoprotein cholesterol ratio (PHR), which suggests that PHR is a potentially valuable inflammatory biomarker. However, the body of current research offers insufficiently strong evidence to clarify the connection between PHR and the incidence of stroke. Therefore, this study aims to elucidate any potential associations between PHR and stroke risk.

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Article Synopsis
  • A polydopamine-modified carbon nanotube/calcium alginate aerogel (P-CNTs/CA) was created in an environmentally friendly way and extensively characterized using various techniques.
  • The aerogel demonstrated a high maximum adsorption capacity for methylene blue (MB) of 506.12 mg/g, following a pseudo-second-order kinetic model for adsorption.
  • The adsorption process was found to be spontaneous and involved multiple interactions such as hydrogen bonding and electrostatic forces; the aerogel maintained a 79% removal efficiency after six cycles of adsorption and desorption.
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Background: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Interferon-stimulated genes (ISGs) are often upregulated in patients with pSS, and anti-SSA/Ro 60 antibodies are among the main items detected in pSS. However, the relationship between ISGs and anti-SSA/Ro 60 antibodies in pSS remains unclear.

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Epsilon-poly-lysine (EPL) is widely used in food preservatives. However, EPL can react with components in food substrates, resulting in the formation of precipitates that reduce its antimicrobial properties. Nanoencapsulation is a promising technique and represents a novel approach to enhance EPL activity.

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The oral and gastrointestinal (GI) tract microbiota in humans is susceptible to geographical influences and represents vital factors impacting healthy aging. The northeastern region of China, characterized by distinct dietary and climatic conditions, significantly influences the human microbiome composition. However, the microbial structure of the entire long-lived population in this area has not been evaluated.

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