Publications by authors named "Yanhui Han"

Chicken coccidiosis, caused by Eimeria spp., is an economically important disease of commercial poultry. Innate immunity ensures an immediate response to invading parasites, and Toll-like receptors (TLRs) are major components of the innate immune system.

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Concerns about the safety of food additives have intensified among consumers, scientists, and policymakers. Ensuring the safety of these additives is crucial to public health. Carrageenan (CGN), a common additive in the food industry, has become the subject of controversy, particularly regarding whether it can be degraded in the gastrointestinal tract, forming degraded carrageenans (dCGNs) that may pose health risks.

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A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved. The objective of this study was to investigate the regulatory effect of KFP on the gut microbiota metabolism and intestinal barrier of ulcerative colitis (UC) mice induced by dextran sulfate sodium (DSS). KFP significantly improved the UC symptoms including weight loss, shortened colon length, splenomegaly, diarrhea, hematochezia, and colon inflammation of mice.

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Fermenting edible filamentous fungi with food industry by-products, such as young apples, shows promise for producing mycoproteins and functional peptides. This study aimed to evaluate the production of mycoprotein by fermenting different edible-grade filamentous fungi using young apples as a substrate. Schizophyllum commune DS1 (DS1) demonstrated significant potential for generating mycoprotein, yielding 33.

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Article Synopsis
  • Chicken coccidiosis, caused by Eimeria spp., significantly impacts the poultry industry, but research has mainly focused on acquired immune responses, leaving a gap in understanding innate immunity.
  • A study utilized quantitative real-time PCR to analyze the expression of chicken toll-like receptors (chTLRs) and cytokines in chickens infected with Eimeria tenella, revealing varying patterns of expression during the infection timeline.
  • The findings suggest that specific TLRs and cytokines are actively involved in the innate immune response and may play a key role in developing resistance to chicken coccidiosis.
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The present study identified the protective effects of garlic oligo/poly-saccharides of different chain lengths against dextran sulfate sodium (DSS)-induced colitis in mice and elucidated the structure-function relationships. The results showed that oral intake of garlic oligo/poly-saccharides decreased disease activity index, reduced colon shortening and spleen enlargement, and ameliorated pathological damage in the mouse colon. The dysregulation of colonic pro/anti-inflammatory cytokines was significantly alleviated, accompanied by up-regulated antioxidant enzymes, blocked TLR4-MyD88-NF-κB signaling pathway, enhanced intestinal barrier integrity, and restored SCFA production.

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  • Curcumin is known for its health benefits, but the impact of gut bacteria on its metabolism was previously under-researched.
  • This study isolated two new bacterial strains (UMA_cur1 and UMA_cur2) from human stool samples that effectively convert curcumin into various metabolites.
  • Notably, UMA_cur2 can produce unique compounds like hexahydro-curcumin and octahydro-curcumin, suggesting a complex interaction between curcumin and gut microbiota, with potential implications for its health effects.
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  • Bioactive components from Porphyra tenera (PT) have potential health benefits, particularly in relation to inflammatory bowel disease (IBD), which has not been thoroughly researched.
  • A study with DSS-treated mice showed that PT supplementation reduced colitis severity by improving disease activity, repairing colonic damage, and lowering abnormal inflammation.
  • Additionally, PT helped restore healthy gut microbiota and the production of beneficial short-chain fatty acids (SCFAs) and bile acids (BAs), suggesting edible seaweeds like PT could help prevent inflammation-related disorders in humans.
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Curcumin might exert its therapeutic effects by interacting with gut microbiota. However, the role of gut microbiota in curcumin metabolism in vivo remains poorly understood. To address this, we used antibiotics to deplete gut microbiota and compared curcumin metabolism in control and antibiotic-treated mice.

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Pleurotus eryngii, an edible mushroom recognized for its potent polysaccharides, demonstrates significant regulatory effects on metabolic processes. β-glucan (WPEP) derived from P. eryngii has been noted for its therapeutic potential, exhibiting notable benefits in alleviating colonic inflammation and restructuring gut microbiota in mice treated with dextran sodium sulfate (DSS).

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Cortisol is a vital glucocorticoid hormone reflecting stress levels and related disease processes. In this study, we report an aptamer-functionalized plasmonic nano-urchin (α-FeOOH@Au-aptamer)-aided cortisol-capturing and surface-enhanced Raman spectroscopy (SERS) analysis approach. The designed α-FeOOH@Au-aptamer exhibits a well-patterned plasma structure, which combines the good SERS enhancement ability of reduced nanogaps between the Au plasma and the hot spot-favored structure of anisotropic tips from α-FeOOH urchins, with the high affinity of the aptamer towards cortisol molecules.

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  • The probiotic strain G7, isolated from a healthy male, shows promise for promoting gastrointestinal health and reducing inflammation.
  • In lab tests, G7 significantly inhibited inflammatory responses in macrophages and lessened colonic inflammation in mice treated with dextran sulfate sodium (DSS).
  • Sequencing analysis indicated that G7 improved gut microbiota balance and altered bile acids and short-chain fatty acids (SCFAs), supporting its potential as a novel anti-inflammatory probiotic.
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There is a growing interest in employing whole food-based strategies to prevent chronic diseases, owing to the potential synergistic interactions among various bioactive components found within whole foods. The current research aimed to determine inhibitory effects of the whole edible mushroom Pleurotus eryngii (WPE) on high-fat diet (HFD)-induced obesity in mice. Our results showed that dietary intake of WPE significantly inhibited the abnormal gain of body weight and adipose tissue weight, improved glucose tolerance, and ameliorated the serum biochemical parameters in HFD-fed mice.

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Chicken coccidiosis, caused by Eimeria protozoa, affects poultry farming. Toll-like receptors (TLRs) and host defence peptides (HDPs) help host innate immune responses to eliminate invading pathogens, but their roles in Eimeria tenella infection remain poorly understood. Herein, 14-day-old chickens were treated orally with 50,000 E.

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  • The study examined the protective effects of icaritin (ICT) on leukemia induced by ENU in male mice, finding that ICT could inhibit the disease's progression.
  • Mice with ENU-induced leukemia were treated with ICT, showing that it reduced inflammation and activated apoptosis in critical organs like the spleen and liver by affecting certain protein pathways.
  • The research suggests ICT could be a promising new treatment for leukemia by targeting the IL-6/JAK2/STAT3 pathway and inducing cancer cell death.
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Nobiletin (NOB) exhibits significant biological activities and may be a potential dietary treatment for antibiotic-associated gut dysbiosis. In this study, mice were gavaged with 0.2 mL day of 12.

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The triboelectrification effect caused by dynamic contact between particles is an issue for explosions caused by electrostatic discharging (ESD) in the triboelectric nanogenerators (TENGs) for powering the flexible and wearable sensors. The electrostatic strength of dielectric particles (surface charge density, surface potential, electric field, etc.) is essential to evaluate the level of ESD risk.

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Optimization of metabolic regulation is a promising solution for many pathologies, including obesity, dyslipidemia, type 2 diabetes, and inflammatory liver disease. Synthetic thyroid hormone mimics-based regulation of metabolic balance in the liver showed promise but was hampered by the low biocompatibility and harmful effects on the extrahepatic axis. In this work, we show that specifically directing the thyromimetic to the liver utilizing a nanogel-based carrier substantially increased therapeutic efficacy in a diet-induced obesity mouse model, evidenced by the near-complete reversal of body weight gain, liver weight and inflammation, and cholesterol levels with no alteration in the thyroxine (T4) / thyroid stimulating hormone (TSH) axis.

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Human and animal studies support that consuming a high level of linoleic acid (LA, 18:2ω-6), an essential fatty acid and key component of the human diet, increases the risk of colon cancer. However, results from human studies have been inconsistent, making it challenging to establish dietary recommendations for optimal LA intake. Given the importance of LA in the human diet, it is crucial to better understand the molecular mechanisms underlying its potential colon cancer-promoting effects.

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5-Demethylnobiletin (5DN) is an important ingredient of citrus extract that is rich in polymethoxyflavones (PMFs). In this study, we systemically investigated the preventive effects of 5DN on antibiotic-associated intestinal disturbances. Experimental mice were gavaged 0.

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Titanium dioxide (TiO) is a common additive in foods, medicines, and personal care products. In recent years, nano-scale particles in TiO additives have been an increasing concern due to their potential adverse effects on human health, especially gut health. The objective of this study was to determine the impact of titanium dioxide nanoparticles (TiO NPs, 30 nm) on beneficial gut bacteria and host response from a metabolomics perspective.

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To improve the functional properties of mulberry leaves, γ-aminobutyric acid (GABA) enrichment treatments were applied. The results showed that the combined treatment of sodium glutamate immersion, cold shock, and anoxic significantly increased the GABA content. HPLC analysis displayed that the quantity of some active phenolics was significantly increased after the treatment.

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Although resveratrol (RES) is barely detectable in the plasma and tissues upon oral consumption, collective evidence reveals that RES presents various bioactivities , including anti-inflammation and anti-cancer. This paradox necessitates further research on profiling and characterizing the biotransformation of RES, as its metabolites may contribute profound biological effects. After 4-week oral administration, 11 metabolites of RES were identified and quantified in mice by HPLC-MS/MS, including dihydro-resveratrol (DHR), lunularin (LUN), and conjugates (sulfates and glucuronides) of RES, DHR and LUN.

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, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice.

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