Biodegradation of bisphenol compounds in the surface water of Taihu Lake and the effect of humic acids.

Bisphenol analogues (BPs) pollution in the aquatic environment is increasingly a worldwide concern. There is an urgent need to understand the fate of BPs in the aquatic environment. In this study, we studied the biodegradation of eight BPs in Taihu Lake and discussed the effect of humic acid (HA), which was extracted from Taihu Lake sediment, on the disappearance of BPs.

Effects of Overexpression on Solanesol Content, Plant Growth, Photosynthesis, and Metabolome of .

solanesyl diphosphate synthase 1 (NtSPS1) is the key enzyme in solanesol biosynthesis. However, changes in the solanesol content, plant growth, photosynthesis, and metabolome of tobacco plants after overexpression (OE) have not been previously reported. In the present study, these parameters, as well as photosynthetic gas exchange, chlorophyll content, and chlorophyll fluorescence parameters, were compared between OE and wild type (WT) lines of tobacco.

Presence of organophosphate esters in plasma of patients with hypertension in Hubei Province, China.

Organophosphate esters (OPEs) are widely used as fire retardants, so they are almost ubiquitous pollutants. Recent studies had found that OPEs were detectable in human blood samples. However, the studies on the presence of OPEs in hypertensive patients were limited.

Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways.

Antibiotics had been paid more and more attention to their toxicity to non-target aquatic organisms in the aquatic environment. As azithromycin (AZI) was an important antibiotic pollutant in water, its toxicity to aquatic organisms had been investigated. In this study, the potential aquatic ecological risk of AZI was identified by assessing the toxicity on the feeding behavior and physiological function of Daphnia magna (D.

Positive correlation between human exposure to organophosphate esters and gastrointestinal cancer in patients from Wuhan, China.

As kinds of endocrine disruptors, organophosphate esters (OPEs) pollution in the environment had received increasing attention recently. Food and water intake were two important exposure pathways for OPEs. However, the studies about the potential association between OPEs and gastrointestinal cancer were limited.

Distribution and potential risk assessment of antibiotic pollution in the main drinking water sources of Nanjing, China.

The distribution character of 41 antibiotics belonging to 6 groups, sulfonamides (SAs), quinolones (QUs), tetracyclines (TCs), macrolides (MLs), penicillins (PLs), and chloramphenicol (CHL), was investigated in drinking water sources of Nanjing during 2017-2019. MLs (42.98%) were the most abundant category, followed by SAs (25.

Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma.

The aim of this study was to explore the roles of GPX2, a member of the glutathione peroxidase family (GPXs, GSH-Px), in cisplatin (DDP) resistance in lung adenocarcinoma (LUAD). GPX2 was found to be the most significantly upregulated gene in a DDP-resistant A549/DDP cell line compared with the parental A549 cell line by RNA sequencing. The knockdown of GPX2 expression in A549/DDP cells inhibited cell proliferation and , decreased the IC values of DDP, induced apoptosis, inhibited the activities of GSH-Px and superoxide dismutase (SOD), inhibited ATP production and glucose uptake, and increased malondialdehyde (MDA) and reactive oxygen species (ROS) production; while GPX2 overexpression in A549 cells resulted in the opposite effects.

Systematic profiling of staralog response to acquired drug resistant kinase gatekeeper mutations in targeted cancer therapy.

Kinase-targeted therapy has been widely used as a lifesaving strategy for cancer patients. However, many patients treated with targeted cancer drugs are clinically observed to rapidly develop acquired resistance. Kinase gatekeeper mutation is one of the most chief factors contributing to the resistance, which modulates the accessibility of kinase's ATP-binding pocket.

Effects of dairy products, calcium and vitamin D on ovarian cancer risk: a meta-analysis of twenty-nine epidemiological studies.

Findings for the roles of dairy products, Ca and vitamin D on ovarian cancer risk remain controversial. We aimed to assess these associations by using an updated meta-analysis. Five electronic databases (e.

A mechanically bendable and conformally attachable polymer membrane microlaser array enabled by digital interference lithography.

The progressive miniaturization and thinning of photonic devices would enable the realization of multi-functional photonic integrated circuits and expand the application frontier to novel fields including wearable and disposable electronics. Herein, we have demonstrated a mechanically bendable and conformally attachable polymer membrane microcavity laser array using digital interference lithography. The developed lithography system could distribute a number of subwavelength grating pixels with both high efficiency (1k pixels per second) and excellent versatility (ease of control in the pixel size, spacing, and grating periodicity) as the microcavity laser array, in which a pair of subwavelength gratings constitutes a distributed Bragg resonator microcavity via coherent interference, furnishes a vertically emitting microcavity laser array for convenient light coupling and utilization.

Synthesis of amino acids and peptides with bulky side chains ligand-enabled carboxylate-directed γ-C(sp)-H arylation.

Amino acids and peptides with bulky side chains are of significant importance in organic synthesis and modern medicinal chemistry. The efficient synthesis of these molecules with full enantiocontrol and high diversity remains challenging. Herein we report a Pd-catalyzed ligand-enabled γ-C(sp)-H arylation of -leucine and its derived peptides without using an external directing group (DG) a less favored six-membered palladacycle.

Dynamics of antioxidant activities, metabolites, phenolic acids, flavonoids, and phenolic biosynthetic genes in germinating Chinese wild rice (Zizania latifolia).

In this study, the antioxidant activity of germinating Chinese wild rice was found to decline initially, after which it increased. The largest difference in antioxidant activity was observed between the 36-h (G36) and the 120-h germination (G120) stage. We further assessed the dynamic changes in metabolites, phenolic acids, flavonoids, and phenolic biosynthetic genes in germinating Chinese wild rice.

Puerarin-loaded ultrasound microbubble contrast agent used as sonodynamic therapy for diabetic cardiomyopathy rats.

In this study, a puerarin-loaded ultrasound sulfur hexafluoride microbubble contrast agent as a sonodynamic therapy (SDT) was developed to improve targeted drug delivery and pharmacodynamic effects in diabetic cardiomyopathy (DCM) treatment. Fluorescence microscope morphology was applied to confirm the fabrication of the puerarin - microbubbles (PMBs). The average size distribution and zeta potential of PMBs were 760.

Synthesis of Axially Chiral Styrenes through Pd-Catalyzed Asymmetric C-H Olefination Enabled by an Amino Amide Transient Directing Group.

The atroposelective synthesis of axially chiral styrenes remains a formidable challenge due to their relatively lower rotational barriers compared to the biaryl atropoisomers. Herein, we describe the construction of axially chiral styrenes through Pd -catalyzed atroposelective C-H olefination, using a bulky amino amide as a transient chiral auxiliary. Various axially chiral styrenes were produced with good yields and high enantioselectivity (up to 95 % yield and 99 % ee).

Disseminated cryptococcosis with multiple and mediastinal lymph node enlargement and lung involvement in an immunocompetent child.

Background: Disseminated cryptococcosis is less common in individuals with normal immune function. Most cases occur in HIV-infected people. Usually it affects the lungs, followed by the central nervous system (CNS), skin and bone marrow, but rarely to the lymph nodes and chest wall.

Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis.

Introduction: Nausea and vomiting (NV) affect up to 85% of pregnant women, which has multiple effects on pregnancy outcome. The truth etiology of nausea and vomiting in pregnancy (NVP) is still unknown. Considering the potential teratogenic effect in fetus due to chemical drugs, ginger can be used to treat nausea and vomiting during pregnancy.

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness.

TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions. Aberrant expression of TGIF family proteins has been observed in several cancers, including ovarian, esophageal, and colorectal cancers. Here, we report that TGIF2 mediates the EGFR-RAS-ERK signaling pathway to enhance the stemness of lung adenocarcinoma (LUAD) cells and, therefore, promote the progression and metastasis of LUAD.

[Occurrence Characteristics and Risk Assessment of Antibiotics in Source Water of the Nanjing Reach of the Yangtze River].

Occurrence characteristics of antibiotics in the source water of the Nanjing section of the Yangtze River were analyzed preliminarily by solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS). The results showed that the cumulative concentration of 16 sampling points ranged from 13.37 ng·L to 780.

The bioaccumulation, elimination, and trophic transfer of BDE-47 in the aquatic food chain of Chlorella pyrenoidosa-Daphnia magna.

As a persistent organic pollutant, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) has been widely detected in aquatic environments. However, studies on the fate and transfer of BDE-47 in the aquatic food chain remain scarce. In this study, we investigated the bioaccumulation and elimination of BDE-47 in Chlorella pyrenoidosa, as well as the trophic transfer and biomagnification of BDE-47 in the "C.

Evaluation of antimicrobial activity of water-soluble flavonoids extract from Thunb. leaves.

Aqueous extract of Thunb. leaves (VWFE) is traditionally used for food preservation in China, which is rich in flavonoids compounds. VWFE could effectively inhibit the growth of both Gram negative () and positive bacteria ( and ), however, no inhibition effects were observed on mold and yeast.

Association between lipid profiles and presence of carotid plaque.

It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and December 2017 in China, to investigate the association between various lipid profiles and the prevalence of carotid plaque.

RHAMM inhibits cell migration via the AKT/GSK3β/Snail axis in luminal A subtype breast cancer.

Breast cancer is one of the most common types of cancer in women. Although the mortality rate of breast cancer has fallen over the past 10 years, effective treatments that reduce the occurrence of breast cancer metastasis remain lacking. In this study, we explored the role of receptor for hyaluronan mediated motility (RHAMM) and the associated signaling pathway in cell migration in luminal A breast cancer.

Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents.

Background: Epilepsy is a serious and common neurological disorder threatening the health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present many limitations. These limitations prompted the development of more safer and effective AEDs.