Identification and Validation of an Inflammatory Response-Related Polygenic Risk Score as a Prognostic Marker in Hepatocellular Carcinoma.

Aims: We hypothesized that the expression patterns of inflammatory response-related genes may be a potential tool for hepatocellular carcinoma (HCC) risk scoring.

Background: Inflammatory response plays a pivotal role in the pathogenesis of HCC.

Objective: To establish and validate a hallmark inflammatory response gene-based polygenic risk score as a prognostic tool in HCC.

Effect of dexamethasone injection into Zusanli (ST 36) acupoint on ovalbumin-induced allergic rhinitis.

Objective: To investigate the effects of acupuncture with dexamethasone (A. Dex) on allergic rhinitis (AR) by injecting dexamethasone into the Zusanli (ST 36) acupoint.

Methods: Thirty 6-week-old female BALB/c mice were sensitized on days 1, 5, and 14 by intraperitoneal injection of 100 µg of ovalbumin (OVA).

Puerarin-loaded ultrasound microbubble contrast agent used as sonodynamic therapy for diabetic cardiomyopathy rats.

In this study, a puerarin-loaded ultrasound sulfur hexafluoride microbubble contrast agent as a sonodynamic therapy (SDT) was developed to improve targeted drug delivery and pharmacodynamic effects in diabetic cardiomyopathy (DCM) treatment. Fluorescence microscope morphology was applied to confirm the fabrication of the puerarin - microbubbles (PMBs). The average size distribution and zeta potential of PMBs were 760.

Therapeutic effects of statins drugs use and continuous nursing on patients with chronic obstructive pulmonary disease and the influence of life quality.

Chronic obstructive pulmonary disease (COPD) is able to be treated and delayed. Many interventions include smoking cessation and daily maintenance of drug therapy. In clinical practice, although respiratory physicians have given optimal drug treatment to patients, there is no treatment for etiological factors in these treatments, and they have little effect on the long-term prognosis of COPD.

Experimental Evaluation of the Transport Mechanisms of PoIFN-α in Caco-2 Cells.

For the development of an efficient intestinal delivery system for Porcine interferon-α (PoIFN-α), the understanding of transport mechanisms of which in the intestinal cell is essential. In this study, we investigated the absorption mechanisms of PoIFN-α in intestine cells. Caco-2 cells and fluorescein isothiocyanate-labeled (FITC)-PoIFN-α were used to explore the whole transport process, including endocytosis, intracellular trafficking, exocytosis, and transcytosis.

A hexameric [MnNa] wheel based on [MnO] sub-units.

A novel hexameric [MnNa] wheel-like aggregate consisting of [MnO] triangles is reported. It is the second highest nuclearity oxime-based Mn cluster, the largest member of the recently-developed family of molecular oligomers based on [MnO] triangles, and the only one with a wheel-like metal topology.

Long noncoding ribonucleic acids maternally expressed gene 3 inhibits lung cancer tumor progression through downregulation of MYC.

Objective: Long noncoding ribonucleic acids (RNAs) nowadays emerge as important biomarkers or potential therapeutic targets discussed in human cancers. Among them, maternally expressed gene 3 (MEG3) is known to be decreased in a variety of malignancies.

Materials And Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to detect the expression of MEG3 in forty pairs of lung cancer (LC) tissues.

[Treatment of skin and soft tissue defect in the hallex with flaps ].

Objective: To summarize the therapeutic effect of 5 kinds of flaps for the treatment of skin and soft tissue defect in the hallex.

Methods: From Jan. 2008 to Jun.

Genome Sequences of Simian Hemorrhagic Fever Virus Variant NIH LVR42-0/M6941 Isolates (Arteriviridae: Arterivirus).

Simian hemorrhagic fever virus (SHFV) variant NIH LVR42-0/M6941 is the only remaining SHFV in culture, and only a single genome sequence record exists in GenBank/RefSeq. We compared the genomic sequence of NIH LVR42-0/M6941 acquired from the ATCC in 2011 to NIH LVR42-0/M6941 genomes sequenced directly from nonhuman primates experimentally infected in 1989.

Aphrodisiac properties of Allium tuberosum seeds extract.

Aim Of The Study: In the present study, we examined the effect of Allium tuberosum seeds extract upon the expression of male rat sexual behavior, in order to know whether Allium tuberosum seeds extract possess aphrodisiac property.

Materials And Methods: The aphrodisiac activity of Allium tuberosum seeds n-BuOH extract was investigated in male rats. The extract (500 mg/kg body weight/day) and L-dopa (100 mg/kg body weight/day) were administered orally by gavages for 40 days.

Studies on 1:12 phosphomolybdic heteropoly anion film modified carbon paste electrode.

A 1:12 phosphomolybdic anion film modified carbon paste electrode (PMo(12) electrode) is prepared by electrochemical deposition and its application is studied by cyclic voltammetry. The film modified electrode can adsorb PMo(12) selectively and thus be used for the determination of trace phosphorus. In a solution containing 2 mug ml(-1) phosphorus, the relative standard deviation is 4.