Publications by authors named "Yanhu Shi"
The Effect of Methamphetamine on Ventricular Myocytes of Neonatal Rats.
Altern Ther Health Med
March 2024
Article Synopsis
- - The research examined how MDMA affects gap junction proteins, specifically connexin 43, in heart cells, aiming to uncover the toxic effects of MDMA on heart function.
- - Using neonatal rats, scientists created an in vitro model to analyze the impact of MDMA exposure on connexin 43 levels, its distribution, phosphorylation status, and intracellular calcium dynamics in cardiac cells.
- - Findings indicated that MDMA significantly reduces connexin 43 levels and alters its distribution and phosphorylation, leading to disrupted calcium balance in heart cells, contributing to MDMA’s harmful effects on the heart.
Myocardial hypertrophy is a pathological thickening of the myocardium, leading to various ailments, such as myocardial infarction and heart failure. RBM38 is critical in modulating mRNA translation for multiple protective activities such as p53 tumor repressor and p21 kinase cell cycle inhibitors. Liver X receptors (LXR-α) agonists reduce cellular hypertrophy initiated by various hypertrophic stimuli as lipopolysaccharides and Ang II.
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