Publications by authors named "Yanhong Li"

Background: Acute myeloid leukemia (AML) is a common hematological tumor, but it is difficult to treat. DNMT1 is a DNA methyltransferase whose main function is to maintain stable DNA methylation during the DNA replication process. DNMT1 also plays an important role in AML, but its function in cytokine-induced memory-like natural killer (CIML NK) cell activity remains unclear.

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Calcineurin (CN), a serine/threonine protein phosphatase regulated by Ca and calmodulin, plays a crucial role in the immune response of bivalves. In this study, we examined the effects of gene silencing of the CN subunit (HcCnAα) in Hyriopsis cumingii on the expression of genes associated with the NF-κB signaling pathway, as well as the phosphorylation of the inhibitor of NF-κB (IκB), through RNA interference (RNAi), quantitative PCR (qPCR), and Western blot (WB) analyses. The IκB kinase (HcIKK) and B-cell CLL/lymphoma 10 (HcBcl10) genes of H.

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The presence of abundant hydroxyl groups on the surface of AlO can promote the dispersion of Ni species but produce an inactive NiAlO phase at high temperatures. Moreover, the catalysts prepared by the conventional incipient wetness impregnation method lack the sites for the activation of CO, which leads to coke deposition and thus affects the catalyst activity. The above restricts the utilization of Ni in conventional Ni/AlO catalysts.

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Background: Metabolic disorders are common in individuals with Turner syndrome (TS). Hyperuricemia is associated with metabolic syndrome. This study investigated the serum uric acid (SUA) profile in patients with TS.

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Background: Acute myocardial infarction (AMI) is a significant clinical challenge. Semaglutide has therapeutic potential in cardiovascular disease management, but its specific impact and mechanisms in AMI are not fully understood.

Methods: Twenty-four male Sprague-Dawley rats were divided into three groups: control (Control), infarction-only (MI), and semaglutide-treated (SEMA).

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With ordered and periodic network structures, adjustable pore sizes and high chemical stability, covalent organic frameworks (COFs) have drawn much attention for the fabrication of superior separation membranes. However, it is challenging to prepare COF membranes with a molecular sieving property for gas separation due to their relatively large pore size. In this work, we develop the MOF-in-COF concept for vacuum-assisted synthesis of metal-organic framework (MOF) ZIF-8 inside the pores of TB-COF formed from trihydroxy-benzene-tricarbaldehyde (T) and diamino-biphenyl-disulfonic acid (B), thus constructing a novel ZIF-8@TB-COF membrane.

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Article Synopsis
  • Kidney transplant ultrasonography is a useful nonradiation imaging tool that helps assess transplant health, but its overuse can lead to unnecessary healthcare costs and interventions.
  • A study found that over 30% of hospitalized kidney transplant patients underwent an ultrasound within the first 24 hours, but most didn't result in changes to their treatment or require further procedures.
  • The research showed that selective use of ultrasounds could save around $80,000 CAD annually, suggesting that while ultrasonography provides valuable information, its widespread application may not significantly enhance kidney transplant care.
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  • The study focused on the thioredoxin system in the bivalve Hyriopsis cumingii, specifically cloning and characterizing the thioredoxin reductase 1 gene (HcTrxR1) and its interaction with the Nrf2 protein (HcNrf2).
  • Researchers successfully cloned the HcTrxR1 gene, which encodes a 595-amino acid protein and is conserved among bivalves, with highest mRNA expression found in gonads and hemolymph.
  • The results indicate that HcNrf2 regulates HcTrxR1 expression through two critical antioxidant response elements in its promoter, revealing important insights into the antioxidant mechanisms in bivalves and implications for
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Plants of , belonging to the Zygophyllaceae family, are not only widely distributed at an altitude of about 1000 m but also at an altitude of about 3000 m, which is a rare phenomenon. However, little is known about the effect of altitude on the accumulation of metabolites in plants of . Furthermore, the mechanism of the high-altitude adaptation of has yet to be fully elucidated.

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Objective: To analyze the clinical characteristics of critically ill neonates in the neonatal intensive care unit (NICU) who acquired Serratia marcescens infection for onset or colonization, and to explore the risk factors contributing to the onset of Serratia marcescens infection.

Methods: A retrospective case-control study was conducted by collecting clinical data from NICU neonates at the Women and Children's Hospital of Ningbo University between January 2017 and December 2023. Forty-four neonates with clinical signs and/or symptoms consistent with Serratia marcescens infection, and with Serratia marcescens isolated from specimens, would be enrolled as the infection onset group, while 45 neonates who tested positive for Serratia marcescens in rectal and/or pharyngeal cultures during the same period, but had no clinical signs or infection symptoms, were enrolled as the colonization control group.

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Current biomarkers for sepsis-associated acute kidney injury (SA-AKI) lack specificity. The role of soluble urokinase plasminogen activator receptor (suPAR) in discriminating AKI and SA-AKI in children remains elusive. This prospective multicenter study was conducted in critically ill children cohorts using a derivation-validation design, and plasma samples were collected within first 24 h after admission.

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In this study, the nuarimol enantiomers were successfully baseline separated with Rs 1.70 by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The absolute configurations of the nuarimol enantiomers were confirmed as -(+)-nuarimol and -(-)-nuarimol.

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The rebound of liquid droplets on solid surfaces exhibits behavior reminiscent of elastic spheres, albeit with distinct contact dynamics. While the rapid detachment of droplets from surfaces holds significant relevance for various applications, previous endeavors relying on engineered surfaces can only reduce the contact time to several milliseconds, primarily due to capillary effects dominating droplet bounce. Here, we present ultrafast rebound by designing heterogeneous core-shell droplets encapsulating a particle (DEP), which achieves an unprecedentedly short contact time of 0.

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Graphene films have been applied in the thermal management of electronic devices due to their high thermal conductivity. However, the ever-increasing power and local heat flux density of electronic chips require graphene films with excellent heat flux carrying capacity. Enhancing the heat flux carrying capacity is highly challenging, and the key is to maintain high thermal conductivity while increasing film thickness.

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Fenpropidin (FPD), a widely utilized chiral fungicide, has been detected in aquatic environments. This study systematically evaluated the bioaccumulation, depuration, biotransformation, and sensitive biomarkers of FPD enantiomers in zebrafish to assess their environmental risks. Compared with S-FPD, R-FPD demonstrated a higher rate of enrichment and an increased level of bioaccumulation.

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Article Synopsis
  • - The study investigates how intraoperative hypotension (low blood pressure during surgery) affects kidney function after transplantation, focusing on duration and levels of mean arterial pressure (MAP).
  • - Analyzing 1,602 kidney transplants over a decade, researchers found that hypotension (specifically, MAP below 65 mmHg for >5 minutes) is linked to a significant risk of delayed graft function (DGF), where kidney function does not improve promptly post-surgery.
  • - While DGF occurred in 33% of patients analyzed, the research suggests that lower MAP levels (especially <55 mmHg) contribute to poorer early kidney function outcomes, but the need for dialysis shortly after transplantation was not tied to intraoperative hypot
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Spontaneous abortion is associated with aberrant lipid metabolism, but the underlying mechanisms remain unclear. Here, we show that lipids are accumulated in decidual stromal cells (DSCs) and macrophages (dMφs) in women with miscarriage and mouse abortion-prone models. Moreover, we show that excessive lipids from DSCs are transferred to dMφs via a CD36-dependent mechanism that induces inflammation in dMφs.

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Background: To introduce a new flange technique (called the Z.S. fixation technique) for 8 - 0 polypropylene suture in scleral fixation of a one-piece intraocular lens (IOL) and evaluate its effectiveness and safety.

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  • The study investigates the link between semaglutide treatment and coronary artery inflammation in patients with type 2 diabetes, using the pericoronary fat attenuation index (FAI) as a biomarker.
  • It involved 497 patients, with 93 receiving semaglutide and 404 not treated with it, comparing their clinical data and coronary imaging results.
  • Findings show that semaglutide treatment is associated with lower FAI in all major coronary arteries, suggesting it may play a role in reducing coronary inflammation and enhancing cardiovascular protection for T2DM patients.
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  • Acute myeloid leukemia (AML) has a high risk of relapse and poor survival, with key roles played by circPVT1 and MEF2A in cancer progression that are still being investigated.
  • Research showed that circPVT1 is overexpressed in AML and is regulated by MEF2A, which enhances cell survival and promotes processes linked to cancer spread called epithelial-mesenchymal transition (EMT).
  • CircPVT1 targets microRNA (miR)-455-3p, influencing the regulation of the MCL1 protein to facilitate cancer cell viability and EMT, suggesting that interrupting this pathway could be a potential therapeutic approach for AML.
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Traumatic dental injuries (TDIs) of teeth occur frequently in children and adolescents. TDIs that impact the periodontal tissues and alveolar tissue can be classified into concussion, subluxation, extrusive luxation, intrusive luxation, lateral luxation, and avulsion. In these TDIs, management of injured soft tissue, mainly periodontal ligament, and dental pulp, is crucial in maintaining the function and longevity of the injured teeth.

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