The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.

Incompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance genes and genetic elements, were predominantly discovered. They exhibit a broad presence in diverse host bacteria, showcasing diversity in geographic distribution and the spectrum of antibiotic resistance genes.

The characterization of an IncN-IncR fusion plasmid co-harboring bla, bla, and bla derived from ST1393 Klebsiella pneumoniae.

Plasmids, as important genetic elements apart from chromosomes, often carry multiple resistance genes and various mobile genetic elements, enabling them to acquire more exogenous genes and confer additional resistance phenotypes to bacteria. Various carbapenem resistance genes are often located on IncN plasmids, and several reports have linked fusion plasmids to IncN plasmids. Therefore, this study aims to explore the emergence, molecular structure characteristics, and resistance features mediated by IncN fusion plasmids carrying multiple carbapenem resistance genes.

Waste Lithium Ion Battery Evolves into Heteroatom Doped Carbon as Oxygen Reduction Electrocatalyst for Aqueous Al-Air Batteries.

Carbon based electrocatalysts prepared by recycling waste power batteries can not only realize the new utilization of waste energy materials, but also obtain cheap and efficient oxygen reduction electrocatalyst for metal-air battery. Based on the cathode carbon of waste LiFePO batteries, nitrogen doped carbon based catalyst NC-1000 is prepared by simple pyrolysis, acid dissolution of LiFePO and high temperature heteroatom doping. The catalyst is characterized by scanning electron microscope, transmission electron microscope and Raman spectrum, and the electrochemical performances of the catalyst and Al-air battery were tested.

Risk factors for kidney stone disease recurrence: a comprehensive meta-analysis.

Background: Kidney stone disease (KSD) is a common illness that causes an economic burden globally. It is easy for patients to relapse once they have suffered from this disease. The reported recurrence rate of KSD ranged from 6.

A novel prognostic model based on immunogenomics for clear cell renal cell carcinoma.

Background: Immune cell infiltration into tumor tissue is closely related to the clinical outcomes of patients with clear cell renal cell carcinoma (ccRCC). This study aimed to screen out potential immune genes associated with ccRCC, analyze their relationships with clinical outcomes, and construct a signature to predict ccRCC.

Methods: The transcriptome RNA-sequencing data in 539 ccRCC and 72 adjacent normal tissues were obtained from TCGA database.

Upregulated immune checkpoint HHLA2 in clear cell renal cell carcinoma: a novel prognostic biomarker and potential therapeutic target.

Background: Clear cell renal cell carcinoma (ccRCC) is a malignant urogenital cancer with high mortality; however, current progress in understanding its molecular mechanism and predicting clinical treatment outcome is limited. Therefore, this study is to evaluate the clinical significance of immune inhibitory molecular human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) in ccRCC prognosis and transcriptional regulatory network.

Methods: Expression of in ccRCC was examined by an online database platform ONCOMINE.

Fine Mapping and Candidate Gene Analysis of the Tiller Suppression Gene ts1 in Rice.

Tiller number is one of the key factors that influences rice plant type and yield components. In this study, an EMS-induced rice tiller suppression mutant ts1 was characterized. Morphological and histological observations revealed that, in the ts1 plants, the tiller buds were abnormally formed and therefore cannot outgrow into tillers.