MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells.

Hepatic progenitor cells (HPCs) persist in adulthood and have the potential to play a major role in regenerating diseased liver. However, the signaling pathways that both directly and indirectly regulate HPCs' self-renewal and differentiation remain elusive. Previously, we identified a bipotent, stem cell antigen-1 (Sca-1) positive HPC population from naïve adult liver tissue.

[Impact of obstructive jaundice upon hepatectomy: experiment with rats].

Objective: To investigate the impact of obstructive jaundice on hepatectomy.

Methods: 120 Wistar rats underwent ligation of the common bile duct to establish animal model of obstructive jaundice. On days 1 after ligation 20 rats underwent 30% hepatic resection + choledochojejunostomy (Group 1) and 20 rats underwent 70% hepatic resection + choledochojejunostomy (Group 2); on day 3 after ligation 10 rats underwent 30% hepatic resection + choledochojejunostomy (Group 3) and 10 rats underwent 70% hepatic resection + choledochojejunostomy (Group 4); on day 5 20 rats underwent 30% hepatic resection + choledochojejunostomy (Group 5) and 20 rats underwent 70% hepatic resection + choledochojejunostomy (Group 6); and on day 7 10 rats underwent 30% hepatic resection + choledochojejunostomy (Group 7) and 10 rats underwent 70% hepatic resection + choledochojejunostomy (Group 8).