Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling.

Background: Human adipose-derived stem cells (ADSCs) exert a strong anti-inflammatory effect, and synovium-derived stem cells (SDSCs) have high chondrogenic potential. Thus, this study aims to investigate whether a combination of human ADSCs and SDSCs will have a synergistic effect that will increase the chondrogenic potential of osteoarthritis (OA) chondrocytes in vitro and attenuate the cartilage degeneration of early and advanced OA in vitro.

Methods: ADSCs, SDSCs, and chondrocytes were isolated from OA patients who underwent total knee arthroplasty.

A lithium ore grade measurement based on the neutron & X-ray bi-modal imaging system.

The grades of the minerals significantly affects the energy consumption and chemical pollution along with the beneficiation process for extracting lithium element from the ores. Based on the large neutrons' macro cross section of the LiO cluster inside the ores, the grades of lithium ores could be analyzed by the thermal neutron penetrating information. In this work, a bimodal imaging method, which utilizes both the information of penetrating neutrons and X-rays delivered by the same electron linear accelerator driven photoneutron system, was proposed to investigate the lithium concentration of each ore.

Axial Compressive Loading Attenuates Early Osteoarthritis by Reducing Subchondral Bone Remodeling.

Background: Mechanical loading and alendronate (ALN) can be used as noninvasive physical therapy methods for osteoarthritis (OA). However, the timing and efficacy for treatments are unknown.

Purpose: To determine whether the timing of mechanical loading and ALN influences the pathobiological changes of OA.

The effect of femoral component valgus/varus angle on the mid-term efficacy of unicondylar knee arthroplasty.

Objective: To investigate the effect of femoral component valgus/varus angle (FCVA) on the mid-term outcome after unicondylar knee arthroplasty.

Methods: Patients who underwent unicompartmental knee replacement in the Department of Bone and Joint Surgery, were retrospectively analyzed. According to the postoperative femoral prosthesis internal and external rotation angle, patients were divided into six groups the postoperative femoral prosthesis internal and external rotation angle: standard group, mildly abnormal group.

A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model.

Growth plate injuries affecting the pediatric population may cause unwanted bony repair tissue that leads to abnormal bone elongation. Clinical treatment involves bony bar resection and implantation of an interpositional material, but success is limited and the bony bar often reforms. No treatment attempts to regenerate the growth plate cartilage.

Nano- and micro-scale zerovalent iron-activated peroxydisulfate for methyl phenyl sulfoxide probe transformation in aerobic water: Quantifying the relative roles of SO, Fe(IV), and OH.

Multiple reactive intermediates have been proposed to be involved in peroxydisulfate (PDS) activation by zerovalent iron (ZVI), including sulfate radical (SO) produced via iron-oxide shell mediated electron transfer, ferryl ion species (Fe(IV)) formed from Fe(II)-PDS interaction, and hydroxyl radical (OH) generated by ZVI aerobic oxygenation. In this study, evolution of the relative role of these intermediates in microscale and nanoscale ZVI (mZVI vs. nZVI) activated PDS processes is comparatively investigated by using a methyl phenyl sulfoxide (PMSO) probe that selectively reacts with Fe(IV) to produce methyl phenyl sulfone (PMSO).

Blockade of Osteoclast-Mediated Bone Resorption With a RANKL-Inhibitor Enhances Bone Formation in a Rat Spinal Fusion Model.

Study Design: Rat spine fusion model.

Objective: The present study aimed to determine whether administration of osteoprotegerin (OPG) in a rat model of spinal fusion increases bone volume, bone density, and decreases osteoclasts in the fusion mass.

Summary Of Background Data: OPG is a soluble RANK-ligand inhibitor that blocks osteoclast differentiation and activation.

An iterative prediction method for designing the moderator used for the boron neutron capture therapy.

Purpose: To conduct research related to slow neutrons, fast neutrons must be mode-rated and shifted to the desired energy region.

Methods: In this research, an iterated prediction method, in which the neutron transportation properties of all materials were characterized by a reflection matrix, , and a transmission matrix, , was proposed to bypass a time-consuming Monte Carlo simulation and predict the performance of the moderator, including the epithermal neutron flux and the dose of fast neutrons and gamma rays, used for boron neutron capture therapy (BNCT). To find the optimal solution in the huge parameter space, a genetic algorithm combined with transmission and reflection matrices was utilized.

Unexpected intradural disc herniation instead of space-occupying tumor at L3-L4 level: a case report and literature review.

Background: Lumbar disc herniation (LDH) is a common disease, with a conventional treatment method, as well as well-established surgical procedure, when necessary. However, some rare cases of LDH, such as intradural disc herniation (IDH), accounting for a very small proportion (approximately 0.3%) of all LDH cases, could lead to intra-operation or post-operation complications, which requires a more circumspect pre-operational radiology analysis and overall management.

Anti-VEGF antibody delivered locally reduces bony bar formation following physeal injury in rats.

Physeal injuries can result in the formation of a "bony bar" which can lead to bone growth arrest and deformities in children. Vascular endothelial growth factor (VEGF) has been shown to play a role in bony bar formation, making it a potential target to inhibit bony repair tissue after physeal injury. The goal of this study was to investigate whether the local delivery of anti-VEGF antibody (α-VEGF; 7.

Field study of PAHs with their derivatives emitted from e-waste dismantling processes and their comprehensive human exposure implications.

Extensive electronic waste (e-waste) recycling might be an important emission source of polycyclic aromatic hydrocarbons (PAHs) mixture, which might induce negative effects on the employees. In the present work, atmospheric pollution patterns of PAHs and their derivatives were determined in five different workshops to dismantle waste printed circuit boards (WPCBs) via thermal treatment. The results showed that mass concentrations of PAHs, chlorinated PAHs (ClPAHs), brominated PAHs (BrPAHs), oxy-PAHs (OPAHs) as well as carbazole (CBZ) were ranged from 1.

In vivo degradation rate of alginate-chitosan hydrogels influences tissue repair following physeal injury.

The physis is a cartilaginous tissue in children's long bones that is responsible for bone elongation. Physeal injuries can heal with bony repair tissue known as a "bony bar," and this can cause growth deformities. Current treatments involve surgical resection of the bony bar and insertion of inert materials in hopes of preventing bony bar re-formation and preserving bone elongation.

Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches.

Physeal injuries can lead to bony repair tissue formation, known as a bony bar. This can result in growth arrest or angular deformity, which is devastating for children who have not yet reached their full height. Current clinical treatment involves resecting the bony bar and replacing it with a fat graft to prevent further bone formation and growth disturbance, but these treatments frequently fail to do so and require additional interventions.

MiR-33b-3p promotes chondrocyte proliferation and inhibits chondrocyte apoptosis and cartilage ECM degradation by targeting DNMT3A in osteoarthritis.

Osteoarthritis (OA) is a common and frequently-occurring disease in middle-aged and older people. A growing number of studies have shown that microRNAs (miRNAs) are involved in the development of OA. However, the role and mechanism of miR-33b-3p in OA remain ill-defined.