The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation.

Background: Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger E-box-binding homeobox 1 (ZEB1) has been demonstrated to be a oncogene in many cancers.

An Interpretable Computer-Aided Diagnosis Method for Periodontitis From Panoramic Radiographs.

Periodontitis is a prevalent and irreversible chronic inflammatory disease both in developed and developing countries, and affects about 20-50% of the global population. The tool for automatically diagnosing periodontitis is highly demanded to screen at-risk people for periodontitis and its early detection could prevent the onset of tooth loss, especially in local communities and health care settings with limited dental professionals. In the medical field, doctors need to understand and trust the decisions made by computational models and developing interpretable models is crucial for disease diagnosis.

Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis.

Advanced osteoradionecrosis (ORN) is one of the most serious complications in patients with head and neck cancer, resulting in poor prognosis. Numerous studies have therefore focused on the pathogenesis and interventions of ORN early stage. The present study aimed to investigate whether α2‑macroglobulin (α2M) could prevent early‑stage jaw osteoradionecrosis caused by radiotherapy (RT).

Periodontitis and inflammatory bowel disease: a meta-analysis.

Background: Periodontitis was reported to be associated with inflammatory bowel disease (IBD). However, the association between them has not been firmly established in the existing literature. Therefore, this meta-analysis was conducted to evaluate the relationship between periodontitis and IBD.

Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma.

Background: Immune-related genes (IRGs) were linked to the prognosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to identify the effects of an immune-related gene signature (IRGS) that can predict the of HNSCC prognosis.

Methods: The expression data of 770 HNSCC patients from the TCGA database and the GEO database were used.

Different transmission routes and the risk of advanced HIV disease: A systematic review and network meta-analysis of observational studies.

Background: A substantial proportion of people living with HIV (PLHIV) present for care with advanced HIV disease (AHD), which may result in difficulty reaching the "90-90-90" target to end AIDS in 2030. We assessed the risk of AHD for different transmission routes to summarize the evidence for priority prevention strategies for key populations.

Methods: Observational studies published before September 10th, 2019 in the PubMed, EMBASE, Web of Science and Chinese electronic databases were analysed.

Correction: Epstein-Barr virus infection and oral squamous cell carcinoma risk: A meta-analysis.

[This corrects the article DOI: 10.1371/journal.pone.

Epstein-Barr virus infection and oral squamous cell carcinoma risk: A meta-analysis.

Background: The evidence for association between Epstein-Barr virus (EBV) infection and risk of oral squamous cell carcinoma (OSCC) is inconsistent in the literature. Therefore, this meta-analysis was conducted to clarify this association.

Methods: A literature search was conducted in electronic databases for English- and Chinese-language publications until March 31, 2017 to include eligible case-control studies.