Cardiac arrhythmia in a mouse model of sodium channel epileptic encephalopathy.

Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene , encoding the sodium channel Na1.6, result in EIEE13 (OMIM 614558), which has a 10% risk of SUDEP.