Pneumocystis carinii infection drives upregulation of Fn1 expression that causes pulmonary fibrosis with an inflammatory response.

Background: Pneumocystis carinii is an opportunistic fungal pathogen that may cause pneumonia and lead to pulmonary fibrosis.

Aims: This study attempted to investigate the role of P. carinii infection-related genes in regulating lung fibrosis in mice.

Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment.

Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of apatinib plus chemotherapy in patients with advanced LUAD. A total of 145 patients with advanced LUAD and negative driver genes who received apatinib plus chemotherapy (n=65) or chemotherapy alone (n=80) were analyzed.

Structures and Dynamics of β-Rich Oligomers of ATTR (105-115) Assembly.

Transthyretin (TTR) is a tetrameric homologous protein that can dissociate into monomers. Misfolding and aggregation of TTR can lead to amyloid transthyretin amyloidosis (ATTR), which can cause many diseases (e.g.

The body mass index and the risk of ectopic pregnancy: a 5-year retrospective case-control study.

Purpose: Acknowledging the associated risk factors may have a positive impact on reducing the incidence of ectopic pregnancy (EP). In recent years, body mass index (BMI) has been mentioned in research. However, few studies are available and controversial on the relationship between EP and BMI.

AI-based Virtual Screening of Traditional Chinese Medicine and the Discovery of Novel Inhibitors of TCTP.

Background: Translationally controlled tumour protein (TCTP) is associated with tumor diseases, such as breast cancer, and its inhibitor can reduce the growth of tumor cells. Unfortunately, there is currently no effective medication available for treating TCTP-related breast cancer.

Objective: The objective of this study was to explore the inhibitor candidates among natural compounds for the treatment of breast cancer related to TCTP protein.

AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3.

This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected.

3D printing of thermosets with diverse rheological and functional applicabilities.

Thermosets such as silicone are ubiquitous. However, existing manufacturing of thermosets involves either a prolonged manufacturing cycle (e.g.

Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer the TP53/CDKN1A Pathway.

Background: Chemotherapy is the common treatment for cervical cancer, and the occurrence of drug resistance seriously affects the therapeutic effect of cervical cancer. Our previous study found that PRKD2 mutations occurred only in cervical cancer patients with chemotherapy resistance. However, the relationship between PRKD2 and drug resistance of cervical cancer remains unknown.

[Design and implementation of postoperative evaluation pipeline of deep brain stimulation by multimodality imaging].

Deep brain stimulation (DBS) surgery is an important treatment for patients with Parkinson's disease in the middle and late stages. The accuracy of the implantation of electrode at the location of the nuclei directly determines the therapeutic effect of the operation. At present, there is no single imaging method that can obtain images with electrodes, nuclei and their positional relationship.

Pyrolytic Carbon-coated Cu-Fe Alloy Nanoparticles with High Catalytic Performance for Oxygen Electroreduction.

Well-dispersed carbon-coated or nitrogen-doped carbon-coated copper-iron alloy nanoparticles (FeCu@C or FeCu@C-N) in carbon-based supports are obtained using a bimetallic metal-organic framework (Cu/Fe-MOF-74) or a mixture of Cu/Fe-MOF-74 and melamine as sacrificial templates and an active-component precursor by using a pyrolysis method. The investigation results attest formation of Cu-Fe alloy nanoparticles. The obtained FeCu@C catalyst exhibits a catalytic activity with a half-wave potential of 0.

Electroactive Cu-P-Coupled Moieties Doped in Hierarchically Porous Carbon as Efficient Catalysts for the Oxygen-Reduction Reaction.

A porous carbon material that was co-doped with copper and phosphorus (Cu-P-C) was synthesized by the direct thermal conversion of [(Ph P) CuCl ] in the channels of an SBA-15 template and found to be an impressive Cu-based electrocatalyst. The prefabricated Cu-P moieties in the starting [(Ph P) CuCl ] were retained during the preparation process of the catalyst. These Cu-P active sites effectively catalyzed the oxygen-reduction reaction (ORR).

Space-confined synthesis of multilayer Cu-N-doped graphene nanosheets for efficient oxygen electroreduction.

Cu-based carbon electrocatalysts for the oxygen reduction reaction are difficult to compare with the corresponding Fe- or Co-based electrocatalytic materials, owing to their insufficient catalytic activity and stability. Herein, as an impressive Cu-based electrocatalyst, a multilayer Cu-N-doped graphene sheet (Cu-N-GR) is directly synthesized by the thermal conversion of copper(ii) 2,2'-bipyridine in the confined space of lamellar montmorillonites. The open layered morphology of Cu-N-GR materials facilitated the exposure of more active centers and enhanced the flexibility and mobility of charge carriers.