A highly sensitive and selective electrochemical sensor based on polydopamine functionalized graphene and molecularly imprinted polymer for the 2,4-dichlorophenol recognition and detection.

In this work, a sensitive and selective electrochemical sensor based on polydopamine-reduced graphene oxide (PDA-rGO) and molecular imprinted polymers (MIP) modified glassy carbon electrode for detection of 2,4-DCP was fabricated. The PDA-rGO was obtained through the auto polymerization of dopamine in graphene oxide solution at an alkaline environment. The MIP film was performed on the surface of the PDA-rGO modified electrode by electropolymerization the monomer of o-phenylenediamine (o-PD) with the template of 2,4-dichlorophenol (2,4-DCP).

Prevents Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.

is currently the leading cause of nosocomial infection. Antibiotics remain the first-line therapy for -associated diseases (CDAD), despite the risks of resistance promotion and further gut microbiota perturbation. Notably, the abundance of was reported to be significantly decreased in CDAD patients.

A Review on the Relationship Between Chinese Adolescents' Stress and Academic Achievement.

The objective of the present study was to review the research on the relationship between Chinese adolescents' stress and their academic achievement in the past 20 years. The reviewed studies revealed a generally negative relationship between Chinese adolescents' academic stress and academic achievement; however, other factors, notably, psychological resilience, belief in the value of education, and severity of academic stress moderated the strength of the relationship. In addition, influences such as interpersonal stress and financial stress, on academic achievement were also observed.

Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma.

Background: The mechanism underlying tumor spread through air spaces (STAS) has not been well studied. We investigated the role of tumor stromal cells in the pathogenesis of STAS from a pathological perspective and evaluated the prognostic significance of tumor stromal cells and STAS in postoperative patients with lung adenocarcinoma.

Methods: We retrospectively analyzed 208 postsurgical patients with stage I-IIIA lung adenocarcinoma.

Integrated Endotoxin Adsorption and Antibacterial Properties of Cationic Polyurethane Foams for Wound Healing.

Gram-negative bacteria, containing toxic proinflammatory and pyrogenic substances [endotoxin or lipopolysaccharide (LPS)], can lead to infection and associated serious diseases, such as sepsis and septic shock. Development of antimicrobial materials with intrinsically endotoxin adsorption activity can prevent the release of bacterial toxic components while killing bacteria. Herein, a series of imidazolium-type polyurethane (PU) foams with antimicrobial properties were synthesized.

Atherosclerotic Conditions Promote the Packaging of Functional MicroRNA-92a-3p Into Endothelial Microvesicles.

Rationale: Microvesicle-incorporated microRNAs (miRs) are biomarkers and effectors of cardiovascular disease. Whether microvesicle-miR expression is regulated in coronary artery disease (CAD) or not is unknown.

Objective: Here, we explore the expression of circulating microvesicle-miRs in patients with CAD and investigate the role of microvesicle-miR in endothelial cells.

POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.

RNA polymerase I subunit D (POLR1D), which is involved in synthesis of ribosomal RNA precursors and small RNAs, has been shown to be overexpressed in several human cancer types. Nevertheless, the role of POLR1D in the progression of colorectal cancer (CRC) remains unknown. The following study aimed to investigate the role and underlying mechanism of POLR1D in CRC progression.

New 2-(2-phenylethyl)chromone derivatives from agarwood and their inhibitory effects on tumor cells.

Two new chromone derivatives, 7-hydroxy-2-[2-(3'-methoxy-4'-hydroxyphenyl)-ethyl]chromone (), and 6,7-dimethoxy-2-[2-(3'-hydroxyphenyl)-ethyl]chromone () were isolated from the EtOH extract of agarwood of , together with eleven known analogues. Their structures were established by detailed HR-ESIMS, 1D and 2D NMR spectroscopic analysis, as well as comparison with the literature data. Selected the isolates (, , , , ) were tested for their antitumor activities against SMMC-7721, MGC-803 and OV-90 cell lines using the MTT method with cisplatin and paclitaxel as the positive control.

Chemistry of Singlet Oxygen with a Cadmium-Sulfur Cluster: Physical Quenching versus Photooxidation.

We investigated the chemistry of singlet oxygen with a cadmium-sulfur cluster, (MeN)[Cd(SPh)]. This cluster was used as a model for cadmium-sulfur nanoparticles. Such nanoparticles are often used in conjunction with photosensitizers (for singlet oxygen generation or dye-sensitized solar cells), and hence, it is important to determine if cadmium-sulfur moieties physically quench and/or chemically react with singlet oxygen.

The relationship between endothelial function and aortic valve calcification: Multi-Ethnic Study of Atherosclerosis.

Background And Aims: Aortic valve calcification (AVC) may be associated with atherogenic processes arising from endothelial dysfunction (ED). Limited data is available about the relationship between ED, defined by flow mediated dilation (FMD%) and biomarkers, and the prevalence and progression of AVC in a multiethnic population.

Methods: A sample of 3475 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with both initial and repeat CT scans at a mean of 2.

Apios americana Medik flowers extract protects PC12 cells against HO induced neurotoxicity via regulating autophagy.

Since flavonoids are antioxidant compounds, they could beneficially affect neurodegenerative diseases where reactive oxygen species are involved. In this study, we firstly isolated and identified fourteen compounds from the flowers of Apios americana Medik. Then, we tested whether Apios americana Medik flowers water extract (AFWE) exerts a protective effect on HO induced PC12 cells injure.

Hypatulone A, a Homoadamantane-Type Acylphloroglucinol with an Intricately Caged Core from Hypericum patulum.

Hypatulone A (1), an acylphloroglucinol possessing an unprecedented homoadamantane architecture based on a tricyclo-[4.3.1.

Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional PEG-chitosan stabilized silybin nanocrystals.

This study explored the feasibility of using smart nanocaged carrier technology for the delivering of multifunctional mPEG-chitosan stabilized silybin nanocrystals and to enhancing the long-term stability, dissolution velocity and bioavailability of the water insoluble drugs. The methoxypoly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-b-PCL), as nanocaged carrier, was modified with propargyl and azide group and confirmed by FTIR. The methoxypolythylene glycol-grafted chitosan (PEG-CS), as multifunctional stabilizer, were applied for the silybin nanocrystals formulation.

New naphtoquinones derivatives from the edible bulbs of Eleutherine americana and their protective effect on the injury of human umbilical vein endothelial cells.

Seven new naphthoquinone derivatives, named eleutherins A-G (1-7), were isolated from the edible bulbs of Eleutherine americana (Hong-Cong), which belongs to the Iridaceae family. Their structures were elucidated on the basis of spectroscopic analysis including high-resolution-electron spray ionization-mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) techniques. The absolute configurations of compounds 1-4 were determined by experimental and calculated data.

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.

Background: Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved in promoting malignant transformation in cancers. However, the function and underlying mechanisms of SKA3 in CC remain unknown.

Prediction of cadmium concentration in brown rice before harvest by hyperspectral remote sensing.

Cadmium (Cd) contaminated rice has become a global food security issue. Hyperspectral remote sensing can do rapid and nondestructive monitoring of environmental stress in plant. To realize the nondestructive detection of Cd in brown rice before harvest, the leaf spectral reflectance of rice exposed to six different levels of Cd stress was measured during the whole life stages.

Apios americana Medik flowers polysaccharide (AFP-2) attenuates HO induced neurotoxicity in PC12 cells.

Oxidative stress is a critical cause for the progression of neurodegenerative diseases, indicating that screening natural antioxidant and pharmacological targeting of mechanism need more attention. Natural plant polysaccharides are the primary group of natural antioxidants showing mighty antioxidant activity. Therefore, a polysaccharide (AFP-2) from flowers of Apios americana Medik was isolated, purified and characterized.

Texture Analysis Based on Preoperative Magnetic Resonance Imaging (MRI) and Conventional MRI Features for Predicting the Early Recurrence of Single Hepatocellular Carcinoma after Hepatectomy.

Rationale And Objectives: To investigate the value of texture analysis and conventional magnetic resonance imaging (MRI) features for predicting the early recurrence (ER) of single hepatocellular carcinoma (HCC) after hepatectomy.

Materials And Methods: A total of 100 HCC patients were first divided into group A (tumor diameter ≤3 cm) and group B (tumor diameter >3 cm) and then classified into two subgroups with ER or nonearly recurrence. Textural parameters (skewness, kurtosis, uniformity, energy, entropy, and correlation) based on MR images and conventional MRI features were compared between the ER and nonearly recurrence subgroups.

Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity.

In our previous investigation, we found that agarwood essential oil (AEO) has a sedative-hypnotic effect. Sedative-hypnotic drugs usually have an anxiolytic effect, where concomitant anxiety and depression are a common comorbidity. Therefore, this study further investigated the anxiolytic and antidepressant effects of AEO using a series of animal behavior tests on a restraint stress-induced mice model.

[A new naphthalene derivative from bulbs of Eleutherine americana].

A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques, such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date (MS, UV, IR, NMR), which were identified as eleutherol B (1), 4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (2), 8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (3), and isoeleutherine (4). Compound 1 is a new compound.

Evaluating the responses of net primary productivity and carbon use efficiency of global grassland to climate variability along an aridity gradient.

Net primary productivity (NPP) and carbon use efficiency (CUE) are common ecological indicators for assessing the terrestrial carbon cycle. However, despite their widespread use, considerable uncertainties exist toward the response patterns of NPP and CUE to climate variability along an aridity gradient, especially for grassland ecosystems. The aridity index (AI) was calculated in this study to specify arid-humid zones across the global grassland ecosystem.

Imaging of a Novel Strain of via Metabolic Labeling.

Non-toxigenic is regarded as a potential candidate for probiotic owing to its various advantages. We previously isolated a new strain of (ZY-312) and verified its biosafety and capability of inhibiting the growth of pathogens . However, the colonization of ZY-312 in gastrointestinal (GI) tract remains to be determined.

Smart nanocarrier based on PEGylated hyaluronic acid for deacetyl mycoepoxydience: High stability with enhanced bioavailability and efficiency.

Deacetyl mycoepoxydience (DM) nanocrystals core were stabilized by the folate modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) as the active-targeting stabilizer and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) as the reversion of multidrug resistance stabilizer, respectively. The DM nanocrystals was acted as the core and shelled by the polyethylene glycol-hyaluronic acid (PEG-HA). The optimal core-shell system demonstrated superior stability at 4 °C for 6 weeks by the stability study and higher dissolution velocity.