capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota.

() is a Gram-negative, obligate anaerobic, commensal bacterium residing in the human gut and holds therapeutic potential for ulcerative colitis (UC). Previous studies have indicated that capsular polysaccharide A (PSA) of is a crucial component for its effectiveness, possessing various biological activities such as anti-inflammatory, anti-tumor, and immune-modulating effects. We previously isolated and characterized the strain ZY-312 from the feces of a healthy breastfed infant, and extracted its PSA, named TP2.

Determination of the Minimum Uncut Chip Thickness of Ti-6Al-4V Titanium Alloy Based on Dead Metal Zone.

In Ti-6Al-4V titanium alloy micro-machining, since the uncut chip thickness (UCT) is comparable to the radius of the tool cutting edge, there exists a minimum uncut chip thickness (MUCT), and when the UCT is smaller than the MUCT, the plowing effect dominates the cutting process, which seriously affects the machined surface quality and tool life. Therefore, the reliable prediction of the MUCT is of great significance. This paper used Deform to establish an orthogonal cutting simulation model, studied the effect of the dead metal zone (DMZ) on the micro-cutting material flow, determined the DMZ range, and proposed a new method for determining the MUCT based on the DMZ.

Elevated LINC00115 expression correlates with aggressive endometrial cancer phenotypes via JAK/STAT pathway modulation.

This study systematically explores the oncogenic role of the long non-coding RNA (lncRNA) LINC00115 in endometrial cancer (EC) and reveals its unique mechanism in promoting proliferation, invasion, and metastasis via the JAK/STAT signaling pathway. LINC00115 is significantly upregulated in EC tissues and closely associated with advanced TNM staging and lymph node metastasis. Functional assays showed that knockdown of LINC00115 suppressed EC cell proliferation, invasion, and metastasis, while overexpression enhanced these malignant behaviors.

The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic.

Background: Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.

Objective: This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19.

Methods: A total of 102 clinical staff members were included in this study.

Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice.

Background: The interplay between gut microbiota and immune responses is crucial in ulcerative colitis (UC). Though Akkermansia muciniphila (Akk) shows therapeutic potential, the mechanisms remain unclear. This study sought to investigate differences in therapeutic efficacy among different forms or strains of Akk and elucidate the underlying mechanisms.

Identification of transcription factor-lipid droplet-related gene biomarkers for the prognosis of post-acute myocardial infarction-induced heart failure.

Introduction: Patients with acute myocardial infarction (AMI) are at high risk of progressing to heart failure (HF). Recent research has shown that lipid droplet-related genes (LDRGs) play a crucial role in myocardial metabolism following MI, thereby influencing the progression to HF.

Methods: Weighted gene co-expression network analysis (WGCNA) and differential expression gene analysis were used to screen a transcriptome dataset of whole blood cells from AMI patients with (AMI HF,  = 16) and without progression (AMI no-HF,  = 16).

Recent advances in the treatment of non-small cell lung cancer with MET inhibitors.

Recently, research into the oncogenic driver genes associated with non-small cell lung cancer (NSCLC) has advanced significantly, leading to the development and clinical application of an increasing number of approved therapeutic agents. Among these, small molecule inhibitors that target mesenchymal-epithelial transition (MET) have demonstrated successful application in clinical settings. Currently, three categories of small molecule MET inhibitors, characterized by distinct binding patterns to the MET kinase region, have been developed: types Ia/Ib, II, and III.

Automatic magnetic solid phase extraction for rapid and high-throughput determination of neonicotinoid insecticides and their metabolites in serum, breast milk and urine samples.

In this study, an automatic magnetic solid phase extraction method was developed to determine six parent neonicotinoids (NEOs) and three of their metabolites in breast milk, serum and urine samples. As key extraction parameters, the sorbent amount, washing solvent and elution solvent were optimized to 4 mg of HLB packing magnetic sorbent, pure water and acetonitrile, respectively. Recoveries of the analytes ranged between 81% and 121% for bovine milk samples, 64% and 122% for fetal bovine serum samples and 81% and 109% for pooled urine samples, with RSDs of <20%.

A multi-functional oxidative konjac glucomannan/ε-poly-l-lysine hydrogel with antibacterial, haemostatic, and chronic diabetic wound-treating properties.

A chronic diabetic wound, one of the most severe complications of diabetes, has a high incidence and causes great pain to patients, threatening their lives. In this paper, oxidative konjac glucomannan (OKGM) was reacted with ε-poly-l-lysine (EPL) through the dynamic Schiff's base reaction to make a multi-functional hydrogel. This hydrogel had excellent mechanical properties, injectability, self-healing ability, adhesivity and cytocompatibility.

Malignant transformation of nephrogenic adenoma of the bladder: case report and literature review.

Background: Nephrogenic adenoma (NA) is a rare benign tumor that can develop at any site of the urinary system, with the bladder being the most common, followed by the urethra, ureters, renal pelvises, etc. Currently, it is unclear what the pathogenesis of NA is. This study discussed a rare case of malignant transformation from NA to mesonephric adenocarcinoma of the bladder.

ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5.

Glutaminolysis and glycolysis promote the malignant progression of colorectal cancer. The role of activating transcription factor 4 (ATF4) in solute carrier family 1 member 5 (SLC1A5)-mediated glutaminolysis and glycolysis remains to be elucidated. SLC1A5 and ATF4 expression levels are detected in colorectal cancer tissues.

Mitochondrial transplantation rescues Ca homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy.

SLC25A3 encodes mitochondrial phosphate carrier (PiC), which is involved in inorganic phosphate transport. Clinical reports have found that most patients with homozygous or complex heterozygous mutations in SLC25A3 exhibit lactic acidosis, cardiac hypertrophy, and premature death. However, the potential molecular mechanisms underlying these associations remain unclear.

TavWA1 is critical for wheat growth by modulating cell morphology and arrangement.

Plant growth is determined by the production of cells and initiation of new organs. Exploring genes that control cell number and cell size is of great significance for understanding plant growth regulation. In this study, we characterized two wheat mutants, ah and dl, with abnormal growth.

Constructing Ultra-High Current Direct-Current Tribo-Photovoltaic Nanogenerators via Cu/Perovskite Schottky Junction.

Perovskite-based direct-current triboelectric nanogenerators (DC-TENGs) leveraging the tribo-photovoltaic effect have garnered significant attention for their ability to simultaneously harvest mechanical and solar energy, effectively enhancing the output performance of DC-TENGs. Herein, we innovatively construct a rolling-mode Cu/ternary cation perovskite (FAMACsPb(IBr)) Schottky junction DC-TENGs with ultrahigh current output and excellent operational stability. The Cu/perovskite Schottky junction ensures the formation of an internal electric field, promoting carrier separation and directional movement for a stable DC output.

Understanding the impact of introduction of on community functional structure and moisture regulation in the Loess Plateau, China, using a trait-based approach.

Depending on specific environmental conditions, plantations can have a positive or negative impact on ecosystem function. Numerous studies have demonstrated that plantations on the Loess Plateau has decreased the water levels in this area, increasing the risks of water resource security. Understanding the ecosystem function of the plantations is thought to be critical to vegetation restoration in the Loess Plateau.

Improving the Cycling Stability of NCM811 at High-Voltage 4.5V in Ester-Based Electrolytes with LiDFOB.

Nickel-rich layered cathode materials, particularly LiNiMnCoO (NCM811), have garnered significant attention due to their high energy density and impressive electrochemical performance. However, their cycling stability is compromised at elevated voltages, primarily due to structural instability and interfacial degradation. In this study, lithium difluoro(oxalato)borate (LiDFOB) is introduced into a commercial electrolyte based on lithium hexafluorophosphate (LiPF) to elucidate the structural and interfacial changes occurring in NCM811 at a high cut-off voltage of 4.

Network integration and segregation changes in schizophrenia: impact of electroconvulsive therapy.

Background: Studies have confirmed brain network topology disruption in schizophrenia (SZ). Electroconvulsive therapy (ECT) rapidly improves acute psychiatric symptoms, yet the exact mechanism by which it impacts brain network topology in SZ patients remains unclear. This study aims to explore topological changes in SZ patients' whole-brain functional networks during ECT, ultimately elucidating implicated neurological mechanisms.

Systematic Investigation of indole-based BODIPYs: Synthesis, Dual-State Emission, singlet oxygen formation.

Dual-state emission (DSE) dyes that exhibit intense emission in both dilute solution and solid state have obtained significant attention due to their wide applications. Herein, two series of indole-based BODIPYs (IB-BODIPYs) with DSE properties are synthesized through two routes. Those dyes display yellow to red fluorescence emission in dilute solution and red to near-infrared (NIR) fluorescence emission in the solid state.

A Polymeric Hole Transporter with Dual-Interfacial Interactions Enables 25%-Efficiency Blade-Coated Perovskite Solar Cells.

Self-assembly monolayer (SAM) hole transporters, consisting of anchoring, spacer, and terminal groups, have played a significant role in the development of inverted perovskite solar cells (PSCs). However, the weak interaction between perovskite and hydrophobic terminal group of SAMs limits surface wettability and interface stability. To address this issue, two novel hole transporters (named DBPP and Poly-DBPP) with centrosymmetric biphosphonic acid groups are developed.

Metalloporphyrinic metal-organic frameworks for enhanced photocatalytic degradation of a mustard gas simulant.

Four metalloporphyrinic metal-organic frameworks (MOFs) were successfully synthesized and exhibited enhanced activities for the photooxidation of a sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES). Among them, a Sn-porphyrin functionalized 2D MOF, namely CSLA-21-NH(Sn), showed a half-life of 1.5 min for CEES oxidation under blue LED, featuring as one of the fastest photocatalysts for CEES degradation.

Effects of different rearing methods on cocoon silk strength in silkworm Bombyx mori (Lepidoptera: Bombycidae).

In recent years, the use of artificial diet to rear silkworm Bombyx mori (L.) (Lepidoptera: Bombycidae) has advanced rapidly in China. However, significant differences are found in the production and performance of silk from silkworms reared on artificial diet and mulberry leaves, thereby affecting the development of artificial diet usage in sericulture.

Efficient V-Shaped Substrate for Surface and Volume Enhanced Raman Spectroscopic Analysis of Bioaerosol: Prevention from Potential Health Risk.

Bioaerosols pose a great threat to human life and health, and developing highly efficient and accurate identification and analysis methodologies for bioaerosols provides prerequisite knowledge to evaluate their toxicity on human health. In this paper, a rapid and economical method is proposed for the detection of bioaerosols based on surface-enhanced Raman scattering (SERS). The SERS substrate was prepared using an anodic aluminum oxide (AAO) template with an inverted conical (V-shaped) nanopore array structure that was subsequently deposited with Ag nanoparticles (AgNPs) through magnetron sputtering.

Solid-State Fermentation of Wheat Bran with : Impact on Microstructure, Nutrient Release, Antioxidant Capacity, and Alleviation of Ulcerative Colitis in Mice.

This study investigated the effects of solid-state fermentation with on the microstructure of wheat bran, the release of dietary fiber and phenolic compounds, and antioxidant capacity. Compared with unfermented wheat bran, insoluble dietary fiber and phytic acid content decreased, whereas soluble dietary fiber and water-extractable arabinoxylan content increased in culture. Because of the increased release of phenolic compounds, such as ferulic acid and apigenin, and organic acids, such as isobutyric acid, the antioxidant capacity of the culture was considerably improved.