Clinical Value of Abnormal Prothrombin and Carbohydrate Antigen 125 in the Diagnosis of Patients With Gallbladder Cancer.

Objective: This study was aimed at ascertaining the application value of abnormal prothrombin (PIVKA-II) and carbohydrate antigen 125 (CA125) in gallbladder cancer (GBC) diagnosis.

Methods: A total of 70 GBC patients, 70 patients with benign gallbladder diseases (gallbladder stones and gallbladder polyps), and 70 normal health examination people were selected as the malignant, benign, and normal groups, respectively. The differences in serum levels and positive rates of PIVKA-II and CA125 were compared.

Suppressed P3-O3' Phase Transition and Enhanced Na Diffusion Kinetics of O3-Type Layered Oxide Cathode via Multivariate Doping.

O3-NaNiFeMnO has attracted much attention as a cathode for sodium-ion batteries, because of its low cost and high sodium-ion storage capacity. However, its slow Na diffusion kinetics and harmful P3-O3' phase transition with severe bulk strain at high voltage leads to poor rate capability and fast capacity fading. Herein, we propose a multivariate doping strategy with Cu, Mg, and Ti ions to solve the above problems of the O3-NaNiFeMnO cathode.

Building an entropy-assisted enhanced surface on ultrahigh nickel cathodes to improve electrochemical stability.

Increasing the Ni content in Ni-rich cathodes to over 90% can further enhance the energy density and reduce costs. However, this aggravates the issue of lattice oxygen release due to the instability of the layered structure. In this work, an entropy-stabilized surface strategy is used to process ultrahigh nickel cathode LiNiCoMnO (NCM).

A Comprehensive Investigation into the Mechanisms Dictating the Movement of Liquid Crystal Polymer Flakes in Liquid Crystal Hosts.

Integrating microscale liquid crystal polymer flakes into host materials takes advantage of their compact shape and heightened responsiveness to electric fields, facilitating a range of switching capabilities and related applications, such as smart windows and E-paper displays. However, the complex physics controlling the movement of these flakes within liquid crystal hosts remains partly mysterious. This paper aims to elucidate the underlying physics that governs the behavior of nematic liquid crystal polymer flakes within nematic liquid crystal hosts.

Clinical value of microRNA-130a as a marker of acute liver failure and its involvement in disease development.

Objective: This study was to investigate the clinical value of microRNA (miR)-130a in acute liver failure (ALF).

Methods: ALF patients (n = 120, ALF group) and 106 healthy subjects (control group) were enrolled. Serum was collected to detect alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) by automatic biochemical analyzer, and miR-130a by real-time fluorescence quantitative PCR.

Hypoxia differently regulates the proportion of ALDH cells in lung squamous carcinoma H520 and adenocarcinoma A549 cells via the Wnt/β-catenin pathway.

Background: Cancer stem cells (CSCs) are a specific subpopulation of cancer cells with the ability of self-renewal, infinite proliferation, multidifferentiation and tumorigenicity, and play critical roles in cancer progression and treatment resistance. CSCs are tightly regulated by the tumor microenvironment, such as hypoxia; however, how hypoxia regulates CSCs in non-small cell lung cancer (NSCLC) remains unclear.

Methods: The proportion of ALDH cells was examined using the Aldefluor assay.

Mesoporous CoO@CdS nanorods as anode for high-performance lithium ion batteries with improved lithium storage capacity and cycle life.

Transition metal oxides based anodes are facing crucial problems of capacity fading at long cycles and high rates due to electrode degradations. In this prospective, an effective strategy is employed to develop advanced electrode materials for lithium-ion batteries (LIBs). In the present work, a mesoporous CoO@CdS hybrid sructure is developed and investigated as anode for LiBs.

NiCoO@SnSnanosheets on carbon cloth as efficient bi-functional material for high performance supercapacitor and sensor applications.

Bi-functional materials provide an opportunity for the development of high-performance devices. Up till now, bi-functional performance of NiCoO@SnSnanosheets is rarely investigated. In this work, NiCoO@SnSnanosheets were synthesized on carbon cloth by utilizing a simple hydrothermal technique.

General Synthesis of Composition-Tunable High-Entropy Amorphous Oxides Toward High Efficiency Oxygen Evolution Reaction.

High-entropy materials have attracted much attention in the electrocatalysis field due to their unique structure, high chemical activity, and compositional tunability. However, the harsh and complex synthetic methods limit the application of such materials. Herein, a universal non-equilibrium liquid-phase synthesis strategy is reported to prepare high-entropy amorphous oxide nanoparticles (HEAO-NPs), and the composition of HEAO-NPs can be precisely controlled from tri- to ten-component.

Spontaneous redox reaction-mediated interfacial charge transfer in titanium dioxide/graphene oxide nanoanodes for rapid and durable lithium storage.

Titanium dioxide (TiO) anodes show significant advantages in ion storage owing to their low cost, abundant sources, and small volume change during cycling. However, their intrinsic low electronic conductivity and sluggish ion diffusion coefficient restrict the application of TiO anodes, especially at high current densities. The construction of a covalently-bonded interface in TiO-based composite anodes is an effective approach to solve these issues.

Efficacy of immune checkpoint inhibitors in non-small cell lung cancer with NTRK family mutations.

Background: The efficacy of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) patients harboring neurotrophin receptor kinase (NTRK) family mutations remains obscure.

Methods: The Zehir cohort from cBioPortal was used to analyze the mutations (MT) frequency of NTRK family in patients with NSCLC, and their correlation with clinical characteristics and patient survival. The influence of NTRK MT on ICIs efficacy was evaluated in ICIs-treated patients from Samstein cohort and further validated by use of data from OAK/POPLAR cohort.

Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review.

Immune checkpoint inhibitors (ICIs) have a demonstrable treatment response in patients with resectable non-small cell lung cancer (NSCLC). However, immune-related adverse events and tumor progression in patients administered ICIs are of great concern. The present case study is of a 59-year-old male with NSCLC (squamous, stage IIIA) who received neoadjuvant immunotherapy combined with chemotherapy before surgery.

Coupling high entropy oxide with hollow carbon spheres by rapid microwave solvothermal strategy for boosting oxygen evolution reaction.

High entropy oxides (HEOs) are promising oxygen evolution electrocatalysts due to the unique structure, inherent tunability, as well as excellent catalytic activity and stability. Herein, (FeCoNiCrMn)O nanoparticles coupling with the hollow-mesoporous carbon spheres (HCS) has been designed and fabricated by a rapid and efficient microwave solvothermal followed by annealing. The prepared (FeCoNiCrMn)O nanoparticles are highly dispersed on the HCS surface with an average particle size of approximately 3.

Enhancing potassium ions adsorption on mesoporous carbon spheres with abundant internal surface via engineering sulfur doping sites towards superior rate capability.

Mesoporous carbon spheres (MCSs) show great potential for using as high-performance anodes in potassium-ion batteries (PIBs). Design and synthesis of MCSs with suitable multiscale structures and heteroatom doping or co-doping in MCSs are successfully employed to optimize the ion and electron transportation, however, it is still a challenge to explore MCS-based anodes with satisfactory potassium storage performance. In this work, we report novel S-doped MCS samples with abundant internal surfaces for potassium storage.

Predictive value of the prognostic nutritional index in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis.

Purpose: The prognostic nutritional index (PNI), which is derived from the albumin concentration and absolute lymphocyte number, is an effective indicator of cancer patients' nutritional and immunological status. According to multiple studies, PNI was strongly linked to the prognosis of patients with non-small cell lung cancer (NSCLC). The predictive value of PNI for survival outcomes in NSCLC patients receiving immune checkpoint inhibitors (ICIs) is still in dispute at present.

Anatomical variation of sympathetic ganglia in R4+R5 sympathicotomy for primary palmar axillary hyperhidrosis.

Background: R4+R5 sympathicotomy is one of the standard surgical treatments for primary palmar axillary hyperhidrosis (PAH), but the reported outcomes vary. Anatomical variation of sympathetic ganglia is hypothesized to be a cause for this phenomenon. The sympathetic ganglia could be visualized via near-infrared (NIR) fluorescent thoracoscopy, we utilize this novel technique to observe the anatomical variation of sympathetic ganglia T3 and T4 and investigate its relationship with surgical outcomes.

Microwave solvothermal synthesis of Component-Tunable High-Entropy oxides as High-Efficient and stable electrocatalysts for oxygen evolution reaction.

Transition-metal-based high-entropy oxides (HEOs) are appealing electrocatalysts for oxygen evolution reaction (OER) due to their unique structure, variable composition and electronic structure, outstanding electrocatalytic activity and stability. Herein, we propose a scalable high-efficiency microwave solvothermal strategy to fabricate HEO nano-catalysts with five earth-abundant metal elements (Fe, Co, Ni, Cr, and Mn) and tailor the component ratio to enhance the catalytic performance. (FeCoNiCrMn)O with a double Ni content exhibits the best electrocatalytic performance for OER, namely low overpotential (260 mV@10 mA cm), small Tafel slope and superb long-term durability without obvious potential change after 95 h in 1 M KOH.

Recent advances in and characterization techniques for LiLaZrO-based solid-state lithium batteries.

LiLaZrO (LLZO)-based solid-state Li batteries (SSLBs) have emerged as one of the most promising energy storage systems due to the potential advantages of solid-state electrolytes (SSEs), such as ionic conductivity, mechanical strength, chemical stability and electrochemical stability. However, there remain several scientific and technical obstacles that need to be tackled before they can be commercialised. The main issues include the degradation and deterioration of SSEs and electrode materials, ambiguity in the Li migration routes in SSEs, and interface compatibility between SSEs and electrodes during the charging and discharging processes.

Enhanced Interfacial Magnetization is Responsible for the Negative Capacity Fading of Cobalt Ditelluride Anodes for Lithium Storage.

In lithium-ion batteries (LIBs), the stabilized capacities of transition metal compound anodes usually exhibit higher values than their theoretical values due to the interfacial charge storage, the formation of reversible electrolyte-derived surface layer, or interfacial magnetization. But the effectively utilizing the mechanisms to achieve novel anodes is rarely explored. Herein, a novel nanosized cobalt ditelluride (CoTe ) anodes with ultra-high capacity and long term stability is reported.

Effect of LGR4/EGFR signaling on cell growth and cancer stem cell-like characteristics in liver cancer.

Purpose: Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Leucine-rich repeat containing G-protein-coupled receptors 4 (LGR4) participates in tumor progression, invasion, and metastasis. Our study aimed to investigate the effect of LGR4 with epidermal growth factor receptor (EGFR) in HCC cells.

Trends in antineoplastic drug use, cost and prescribing patterns among patients with lung cancer in nine major cities of China, 2016-2020: a retrospective observational study based on inpatient and outpatient hospital data.

Objectives: It is unclear whether the use of antineoplastic drugs for patients with lung cancer in China has changed after the implementation of the national drug price negotiation in 2016 and continual update of clinical guidelines. This study aims to evaluate the trends in antineoplastic drug use, cost and prescribing patterns among patients with lung cancer in major cities of China.

Design: We conducted a retrospective observational study using data from January 2016 to December 2020.

Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis.

Background: Drug repurposing refers to the application of existing drugs to new therapeutic indications. As phenotypic indicators of human drug response, drug side effects may provide direct signals and unique opportunities for drug repurposing.

Objectives: We aimed to identify drugs frequently associated with hypohidrosis or anhidrosis adverse reactions (that is, the opposite condition of hyperhidrosis) from the pharmacovigilance database, which could be potential candidates as anti-hyperhidrosis treatment agents.

ANK2 as a novel predictive biomarker for immune checkpoint inhibitors and its correlation with antitumor immunity in lung adenocarcinoma.

Background: Immune checkpoint inhibitors (ICIs) have been shown to significantly improve the survival of patients with advanced lung adenocarcinoma (LUAD). However, only limited proportion of patients could benefit from ICIs. Novel biomarkers with strong predictability are needed for clinicians to maximize the efficacy of ICIs.