Publications by authors named "Yangui Lin"
Background: Accurate preoperative localization is a challenge in thoracoscopic surgery for multiple pulmonary nodules. In this study, we aimed to assess the accuracy and feasibility of electromagnetic navigation (EN)-guided percutaneous localization.
Methods: We enrolled 50 patients with multiple pulmonary nodules for EN-guided (EN group) or CT-guided (CT group) localization.
Article Synopsis
- Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) are early forms of lung adenocarcinoma (LUAD) associated with a 100% five-year recurrence-free survival rate, making early diagnosis crucial.
- A study analyzed genetic profiles from 90 early-stage LUAD patients using a 689-gene panel, revealing significant differences in mutation frequencies between pre-invasive (AIS/MIA) and invasive adenocarcinoma (IAC).
- The results indicate distinct genomic features between AIS/MIA and IAC, with lower tumor mutation burden in pre-invasive forms, emphasizing the need for precise categorization in clinical practice for better management of LUAD.
Article Synopsis
- - Pulmonary hypertension (PH) is a serious condition linked to blood vessel changes and involves a process called endothelial-to-mesenchymal transition (EndoMT), which contributes to the disease's progression.
- - The study examined the effects of the protein pigment epithelium-derived factor (PEDF), which has shown promise in counteracting EndoMT in cardiovascular issues, on PH in rat models.
- - Results indicated that PEDF levels were decreased in PH, but its overexpression led to improvements in vascular function and structure, reduction of EndoMT, and suggested that it might be a viable target for treating PH by inhibiting the Wnt/LRP6/β-catenin signaling pathway.
Pigment epithelium-derived factor (PEDF) could bind to vascular endothelial growth factor receptor 2 (VEGFR2) and inhibit its activation induced by VEGF. But how PEDF affects VEGFR2 pathway is still poorly understood. In this study, we elucidated the precise mechanism underlying the interaction between PEDF and VEGFR2, and subsequently corroborated our findings using a rat AMI model.
View Article and Find Full Text PDFBackground: This study aimed to compare the analgesic efficacy of transthoracic intercostal nerve block (TINB) and percutaneous intercostal nerve block (PINB) for video-assisted thoracic surgery (VATS) using a retrospective analysis.
Methods: A total of 336 patients who underwent VATS between January 2021 and June 2022 were reviewed retrospectively. Of the participants, 194 received TINB and were assigned to the T group, while 142 patients received PINB and were assigned to the P group.
Objectives: The efficacy of dexamethasone palmitate in extending durations of local anesthetic blocks is uncertain. In a randomized, double-blind study of patients undergoing video-assisted thoracoscopic surgery, we tested whether intravenous or perineural dexamethasone palmitate caused prolonged analgesia after intercostal nerve block.
Methods: A total of 90 patients subjected to video-assisted thoracoscopic surgery between May and December 2022 were randomly assigned to one of three intercostal nerve blocks study arms (n = 30 each), requiring the addition of 0.
Background: Studies have shown that long non-coding RNAs (lncRNAs) are found to be hypoxia-regulated lncRNAs in cancer. Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide, and despite early surgical removal, has a poor prognosis and a high recurrence rate. Thus, we aimed to identify subtype classifiers and construct a prognostic risk model using hypoxia-associated long noncoding RNAs (hypolncRNAs) for LUAD.
View Article and Find Full Text PDFPulmonary hypertension (PH) is a disease characterized by advanced pulmonary vasculature remodeling that is thought to be curable only through lung transplantation. The application of angiogenic hepatocyte growth factor (HGF) is reported to be protective in PH through its anti-vascular remodeling effect, but excessive HGF-mediated immature neovascularization is not conducive to the restoration of pulmonary perfusion because of apparent vascular leakage. As a canonical antiangiogenic molecule, pigment epithelium-derived factor (PEDF) inhibits angiogenesis and reduces vascular permeability in a variety of diseases.
View Article and Find Full Text PDFCurrent investigations suggest that pigment epithelial‑derived factor (PEDF) can mediate the progression of non‑small cell lung cancer (NSCLC) by regulating autophagy. However, the underlying mechanisms associated with autophagy remain poorly elucidated. The aim of the present study was to investigate the association between the PEDF/adenosine 5'‑monophosphate‑activated protein kinase (AMPK)/Unc‑51 like autophagy‑activated kinase 1 (ULK1) pathway and autophagy in NSCLC.
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