Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-B/snail axis in diabetic nephropathy based on network pharmacology analysis.

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, remains a formidable challenge in diabetes management due to the complex nature of its pathogenesis, particularly the epithelial-mesenchymal transition (EMT) process. Our innovative study leverages network pharmacology to explore the therapeutic potentials of Myricetin, a natural flavonoid, focusing on its effects against NOX4, a critical mediator in DN progression. This investigation marks a pioneering approach by integrating network pharmacology to predict and elucidate the inhibitory relationship between Myricetin and NOX4.

Calcium and vitamin D supplements and burnout of anesthesiologists: National cross-sectional study from China.

Objective: Job burnout among anesthesiologists has been consistently high. This study evaluated the association of calcium and vitamin D supplementation with burnout among Chinese anesthesiologists.

Method: A cross-sectional online survey was conducted during April and May 2023.

Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway.

Skeletal muscle atrophy is a common complication of chronic kidney disease (CKD) that affects the quality of life and prognosis of patients. We aimed to investigate the effects and mechanisms of caffeic acid (CA), a natural phenolic compound, on skeletal muscle atrophy in CKD rats. Male Sprague-Dawley rats underwent 5/6 nephrectomy (NPM) and were treated with CA (20, 40, or 80 mg/kg/day) for 10 weeks.

SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.

Background: Diabetic kidney disease (DKD) represents a microvascular complication of diabetes mellitus. Shenkang Pills (SKP), a traditional Chinese medicine formula, has been widely used in the treatment of DKD and has obvious antioxidant effect. Ferroptosis, a novel mode of cell death due to iron overload, has been shown to be associated with DKD.

Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.

Diabetic kidney disease (DKD) stands as a pressing health challenge, with mesangial cell fibrosis identified as a pivotal hallmark leading to glomerular sclerosis. Gaining a deeper grasp on the molecular dynamics behind this can potentially introduce groundbreaking therapeutic avenues. Recent revelations from studies on ROCK1-deficient mice, which displayed resilience against high-fat diet (HFD)-induced glomerulosclerosis and mitochondrial fragmentation, spurred our hypothesis regarding ROCK1's potential role in mesangial cell fibrosis.

Diastereoselective Construction of Fused Carbocyclic Pyrrolidines via a Copper-Catalyzed [3 + 2] Cycloaddition: Total Syntheses of Pancratinines B-C.

A Cu-catalyzed diastereoselective [3 + 2] cycloaddition of 2-arylaziridines and cyclic silyl dienol ethers was developed to efficiently construct fused-[5,] carbocyclic pyrrolidines, which are widespread in bioactive natural products. Mechanistic studies revealed that the high diastereoselectivity of this transformation arose from a sequential retro aza-Michael/epimerization/aza-Michael process. Taking advantage of this newly developed method, the first total syntheses of pancratinines B and C were concisely realized.

Association of preoperative neutrophil-lymphocyte ratio with acute kidney injury in patients with non-cardiac surgery: difference among surgical types.

Purpose: To examine the relationship between Neutrophil-Lymphocyte Ratio (NLR) and Acute Kidney Injury (AKI) in patients undergoing noncardiac surgery, and subgroup analysis was performed for different types of non-cardiac surgery.

Methods: The present retrospective cohort study included 10,159 adult patients who underwent major noncardiac surgery at Nanfang Hospital, Southern Medical University, between 2008 and 2018. Postoperative AKI was defined as an increase in serum creatinine level of at least 0.

Artificial Intelligence-Based Psoriasis Severity Assessment: Real-world Study and Application.

Background: Psoriasis is one of the most frequent inflammatory skin conditions and could be treated via tele-dermatology, provided that the current lack of reliable tools for objective severity assessments is overcome. Psoriasis Area and Severity Index (PASI) has a prominent level of subjectivity and is rarely used in real practice, although it is the most widely accepted metric for measuring psoriasis severity currently.

Objective: This study aimed to develop an image-artificial intelligence (AI)-based validated system for severity assessment with the explicit intention of facilitating long-term management of patients with psoriasis.

Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.

Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types of CKD, and the gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated the effects of Bacteroides plebeius on protein energy consumption in rats with CKD, and our results suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway.

A 2-Fold Interpenetrated Nitrogen-Rich Metal-Organic Framework: Dye Adsorption and CO Capture and Conversion.

A bifunctional ligand strategy for modification of the functional pores is of great significance in the structural design of metal-organic frameworks (MOFs). Herein, a new 2-fold interpenetrated "pillared-layer" 3D Co-MOF, {[Co(HL)(4,4'-bipy)]·DMF·2HO} (), was successfully synthesized by using two kinds of ligands, imidazolecarboxylic acid and pyridine. The metal-carboxylic layers are pillared by the 4,4'-bipy ligand, displaying a 3D framework with rectangular 3D channels (high BET surface of 190.

SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis.

Emerging evidence has indicated that long non‑coding RNAs (lncRNAs) are closely associated with the pathogenesis of ischemic stroke. It has been reported that small nucleolar RNA host gene 12 (SNHG12) serves a critical role in ischemic stroke by acting as a competitive endogenous RNA (ceRNA). SNHG12 competes with various microRNAs (miRs) to regulate RNA transcription of specific targets.

Zeolitic Metal Cluster Carboxylic Framework for Selective Carbon Dioxide Chemical Fixation through the Superlarge Cage.

Metal-organic frameworks (MOFs) with zeolitic structure process fantastic structural metrics and display excellent applications in many aspects; however, they are difficult to assemble. Herein, on the basis of a tetrahedral ZnO cluster and a 3,5-bis(2,4-dicarboxylphenyl)nitrobenzene (HL) ligand, a novel sodalite (SOD) zeolitic cluster framework (ZCF), {[Zn(O)(L)]·4DMF·6HO} (; DMF = ,-dimethylformamide), has been hydrothermally synthesized. Compared with the traditional SOD zeolitic framework of ZIF-8, the cage size of is dramatically improved from 16.

Spastic paraplegia as the predominant phenotype in a cohort of Chinese patients with adrenoleukodystrophy.

Background: X-linked adrenoleukodystrophy (ALD) is one of the most common peroxisomal disorders characterized by abnormal accumulation of very long-chain fatty acids (VLCFA) in plasma and tissues and caused by mutations within ABCD1. Clinically, ALD present with various phenotypes, ranging from asymptomatic type to rapidly progressive childhood cerebral form. However, no remarkable abnormality in cerebral white matter usually makes it difficult to distinguish adult ALD from hereditary spastic paraplegia (HSP).

Enantioselective Total Syntheses of Lyconadins A-E through a Palladium-Catalyzed Heck-Type Reaction.

A novel palladium-catalyzed Heck-type reaction of thiocarbamates has been designed to construct bridged seven-membered-ring systems that are otherwise challenging to prepare. Taking advantage of this newly developed method, enantioselective syntheses of lyconadins A-E (1-5), lycopecurine (6), and dehydrolycopecurine (7) have been realized in a divergent fashion. Our synthetic strategy also features an intramolecular cyclization of a N-chloroamine to forge the C6-N bond, a transannular Mannich-type reaction of a cyclic nitrone to stitch the C4 and C13 together, and a cyclocondensation to deliver the (dihydro-)pyridone motif.

Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia.

Background: Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosomal recessive (AR) HSP patients. Rare studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese population.

Methods: In this study, we investigated 24 Chinese index AR/sporadic patients by targeted next-generation sequencing (NGS), Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA).

Clinical and genetic characterization of a cohort of Chinese patients with hereditary spastic paraplegia.

Pedigree chart of hereditary spastic paraplegia (HSP) patients and chromatogram of novel mutations. A. Pedigree chart of 12 Chinese HSP families with mutation.

Four new metal-organic frameworks based on diverse secondary building units: sensing and magnetic properties.

Four new metal-organic frameworks (MOFs), {[Zn(L)(OH)(HO)]·NMP·2HO} (1), {[HN(Me)][Zn(L)(HO)]·DMF·HO} (2), {[Co(L)(HO)]·2HO} (3) and {[Mn(L)(HO)]·6HO} (4), were assembled employing a symmetrical V-shaped rigid multicarboxylic acid ligand HL (HL = 2,4-di(3',5'-dicarboxylphenyl)benzoic acid) with different metal ions, resulting in versatile frameworks as well as various types of coordination modes of HL. 1 forms a three-dimensional (3D) 4-connected sra net based on trinuclear [Zn(μ-OH)(μ-COO)(μ-COO)] clusters, while 2 displays a 3D (4,6)-connected net based on two types of binuclear [Zn(μ-COO)(μ-COO)] and [Zn(μ-COO)] clusters. 3 and 4 contain similar [M(μ-COO)(μ-COO)] (3, M = Co; 4, M = Mn) clusters but result in different 4-connected 3D and 2D frameworks, respectively.

Two metal-organic frameworks based on a flexible benzimidazole carboxylic acid ligand: selective gas sorption and luminescence.

Two new three-dimensional (3D) porous metal-organic frameworks (MOFs), {[Cd(L)(NMP)(HO)]·2HO} (1) and {[Zn(L)(HO)]·NMP·HO} (2), have been solvothermally synthesized by using Zn(ii) and Cd(ii) ions with HL (HL = 1,4-di(5,6-bicarboxylbenzimidazol-lylmethyl)benzene) in different ratios of HO and NMP (NMP = 1-methyl-2-pyrrolidinone) solvents, all of which have been characterized by elemental analysis, FT-IR spectroscopy, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). As revealed by structural analysis, the HL ligand took different coordination fashions in 1 and 2, and as a result, two MOFs with a novel (3,4,7)-connected trinodal net and (3,6)-connected binodal net were obtained, respectively. The structure comparison reveals that the coordination modes of ligands and the types of metal ions play decisive roles in regulating the final networks of MOFs.

The influence of coordination modes and active sites of a 5-(triazol-1-yl) nicotinic ligand on the assembly of diverse MOFs.

Six new complexes based on 5-(triazol-1-yl)nicotinic acid (HL), namely [Cu(L)(HO)(OH)] (1), [Co(L)(HO)] (2), [Mn(L)(HO)] (3), {[Co(L)(HO)(DMF)(NO)]·(Cl)·DMF·2HO} (4), {[Cu(L)(O)]·CHOH·2.5HO} (5) and {[Co(L)(HO)]·2DMA·2HO} (6), were synthesized under hydro(solvo)thermal conditions. The L ligand in 1-6 reveals various coordination modes and forms diverse secondary building units (SBUs) in the final structures.

Four new 3D metal-organic frameworks constructed by the asymmetrical pentacarboxylate: gas sorption behaviour and magnetic properties.

By using an asymmetrical rigid pentacarboxylic acid ligand, 2,4-di(3',5'-dicarboxylphenyl)benzoic acid (HL), four new three-dimensional (3D) metal-organic frameworks (MOFs), namely {[Cu(HL)(HO)]·2DMF·2HO} (1), {[Co(L)(DMA)]·HN(Me)} (2), {[Co(L)(HO)]·HN(Me)} (3), {[Mn(L)(DMF)(HO)]·HN(Me)} (4), were solvothermally synthesized. HL in 1-4 shows different coordination modes and can easily form various metal clusters (secondary building units, SBUs) in the final structures. 1 is a 3D porous framework with a (4,4)-connected pts topology based on the [Cu(COO)] paddlewheel SBU, wherein six SBUs are connected by twelve HL to get an unprecedented Cu hendecahedron nanocage.

Four super water-stable lanthanide-organic frameworks with active uncoordinated carboxylic and pyridyl groups for selective luminescence sensing of Fe(3.).

Four super water-stable isostructural lanthanide-organic frameworks, [Ln(HL)(H2O)2]n·2H2O (1-Ln) (Ln = Eu, Tb, Nd and Sm), have been successfully synthesized under hydrothermal conditions with 3,5-di(2,4-dicarboxylphenyl)pyridine (H4L) and Ln(NO3)3·6H2O. 1-Ln shows a novel 2D layered structure with uncoordinated carboxylic and pyridyl groups pointing to the interior of interlayer channels. The luminescent properties of 1-Eu in the solid state and one steeped in aqueous solution have been measured, which show excellent luminescence and good luminescent stability in water.