Publications by authors named "Yangshuo Jin"
Article Synopsis
- Myocardial ischemia/reperfusion (I/R) injury involves complex pathology, significantly influenced by oxidative stress.
- The study focuses on the role of ubiquitin-specific protease 7 (USP7) in regulating this injury through proteasome degradation and its connection to the Keap1 pathway, which responds to reactive oxygen species.
- Results show that increased USP7 expression during I/R contributes to heart damage, while its inhibition can reduce oxidative stress, cell death, and improve heart function, highlighting USP7's potential as a therapeutic target.
The underlying mechanism of neointima formation remains unclear. Ubiquitin-specific peptidase 10 (USP10) is a deubiquitinase that plays a major role in cancer development and progression. However, the function of USP10 in arterial restenosis is unknown.
View Article and Find Full Text PDFThe heart regeneration after apical resection and myocardial infarction in neonatal mice has been studied for years. However, the response of neonatal mouse heart under pressure overload is seldom explored. This study aimed to induce pressure overload in neonatal mice through a transverse aortic constriction (TAC) with different-gauge needles so as to investigate the effect of pressure overload on cardiomyocyte proliferation and hypertrophy in these mice.
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