Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism.

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged as a potential therapeutic target. Ganoderic acid A (GAA), which is a lanostane triterpenoid compound derived from edible mushroom , has demonstrated the ability to modulate gut dysbiosis. Thus, we investigated the impact of GAA on IBD using a dextran sodium sulfate (DSS)-induced colitis mouse model.

Constructed a novel of ZnlnS/S-CN heterogeneous catalyst for efficient photodegradation of tetracycline.

Despite S-doped CN can exhibit more efficient photo-reactivity than pure CN, there is still some space to further improve the detaching efficiency of electron-hole and enhance the photocatalytic efficiency of S-CN. The construction of heterojunction is an effective method to promote the photocatalytic efficiency. ZnInS, as a novel photocatalyst, its VB (1.

Construction of 3D sheet-packed hierarchical MoS/BiOBr heterostructures with remarkably enhanced photocatalytic performance for tetracycline and levofloxacin degradation.

In this paper, MoS nanosheets were prepared and deposited on BiOBr microflowers through deposition-hydrothermal strategy. MoS exhibited a string of nanosheets with wrinkled layer outlook, and MoS/BiOBr composites displayed a micro-flower morphology with the diameter of 2-3 μm. Visible-light harvesting performance was significantly improved in the region of 400-600 nm for MoS/BiOBr.

A partial peroxisome proliferator-activated receptor gamma agonist isolated from the roots of .

Chemical constituents of the roots was investigated and twelve known compounds were isolated, including three ent-atisane diterpenes: -(13)-hydroxyatis-16-ene-3,14-dione , -(5β,8α,9β,10α,11α,12α)-11-hydroxyatis-16-ene-3,14-dione , atisane-3-oxo-16α,17-diol ; two kaurene diterpenes: -kaurane-3-oxo-16α,17-diol , -kaurane-3-oxo-16β,17-diol ; one lathyane diterpene of latilagascene B ; two flavonoids: quercetin (), luteolin (); one lignin d-pinoresinol (); one coumarin scopoletin (); together with ethyl gallate (), -hydroxybenzaldehyde (). Their structures were identified based on the extensive spectroscopic analysis in comparison with the literature data. Compounds and were isolated from for the first time.

Glycopeptide-Conjugated Aggregation-Induced Emission Luminogen: A pH-Responsive Fluorescence Probe with Tunable Self-Assembly Morphologies for Cell Imaging.

pH values play an important role in various cell biological processes. Abnormal pH values in living systems are frequently associated with the development of diseases such as cancers, infection, and other diseases. Real-time monitoring of the changes of pH values will give us the significant indication for these diseases' progression.

Preparation and analysis of photochromic behavior of carboxymethyl chitin derivatives containing spiropyran moieties.

1'-(2-Acryloxyethyl)-3,3'-dimethyl-6-nitrospiro[2 -1-benzopyran-2,2'-indoline] (SPA) was synthesized and grafted onto a water-soluble carboxymethyl chitin (CMCH) macromolecule to prepare a photochromic copolymer (CMCH-g-SPA). The structure of CMCH-g-SPA was characterized by Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis, X-ray diffraction (XRD) analysis, water-solubility evaluation, and UV-vis spectroscopy. XRD patterns of CMCH-g-SPA revealed that grafting copolymerization disrupts the CMCH semicrystalline structure, thus improving water solubility.

Construction of a new cascade photogenerated charge transfer system for the efficient removal of bio-toxic levofloxacin and rhodamine B from aqueous solution: Mechanism, degradation pathways and intermediates study.

In this work, a novel cascade system (i.e., SnTCPP/g-CN/BiWO) is successfully constructed using stannum (II) meso-tetra (4-carboxyphenyl) porphyrin (SnTCPP) as the key photovoltaic agent for the first time.

An effective strategy for boosting photoinduced charge separation of AgPO by BiVO with enhanced visible light photodegradation efficiency for levofloxacin and methylene blue.

In this paper, a Z-scheme AgPO/BiVO photocatalyst was successfully prepared by precipitation-deposition method. The AgPO/BiVO composite exhibited enhanced photocatalytic activity and recyclability for levofloxacin and methylene blue degradation under visible light irradiation. In the AgPO/BiVO-0.

Delphatisine D and Chrysotrichumine A, two new diterpenoid alkaloids from Delphinium chrysotrichum.

Chemical investigations of the aerial parts of Tibetan folk medicine Delphinium chrysotrichum resulted in the isolation of two new diterpenoid alkaloids, delphatisine D (1) and chrysotrichumine A (2), together with ten known diterpenoid alkaloids (3-12) and 3β,6α-dihydroxysclareolida (13). Delphatisine D (1) is a rare atisine-type alkaloid from genus Delphinium and is the C-15 epimer of spiramine C which bears an internal carbinolamine ether linkage (N-C-O-C) between C-7 and C-20. Chrysotrichumine A (2) is a rare natural C-diterpenoid alkaloid possessing a nitrone group between C-17 and C-19.

Hydrothermal synthesis of p-CN/f-BiOBr composites with highly efficient degradation of methylene blue and tetracycline.

Construction of heterojunctions with band-suitable different semiconductors has been demonstrated to be an efficient approach to enhance the separation of photoinduced electrons and holes. In this paper, highly efficient heterojuction photocatalysts consisted of porous-CN (p-CN) and flowerlike-BiOBr (f-BiOBr) were successfully synthesized via a deposition-hydrothermal method. The SEM and HRTEM images indicated that BiOBr were successfully deposited on the surface of p-CN and the layered p-CN/f-BiOBr heterojunctions were formed between p-CN and f-BiOBr.

The antioxidant compounds isolated from the fruits of chinese wild raspberry Hu.

Raspberry, the fruit of Hu, is a widely distributed economic staple food in China. It has long been used as a traditional medicine in mainland China to treat kidney enuresis, nocturnal emission and premature ejaculation in clinic. In this paper, six known compounds (-) were purified from the fruits of .

Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach.

Cornus officinalis has been widely used as a precious herb and as the tonic food to improve kidney function in China. Its fruits have been used in many traditional Chinese medicine prescriptions to treat kidney diseases, diabetes, cancer and shock. In this study, a new eco-friendly approach for green synthesis of silver nanoparticles (AgNPs) by using the fruits of Cornus officinalis aqueous extract as a reducing and stabilizing agent.

Cyclized 9,11-secosterol enol-ethers from the gorgonian Pseudopterogorgia americana.

Chemical investigation of the MeOH extract from the gorgonian Pseudopterogorgia americana afforded two rare sterols, ameristerenol A (1) and B (2), both 9,11-secosterols possesses a seven-membered cyclic enol-ether in ring C, and ameristerol A (3) is the first example of a naturally occurring 9,11-secosterol containing a gorgosterol side chain with a C-24(28) double bond. Ameristerenol A (1) was converted to the sterol derivatives 4-6 to provide additional chemical diversity and comparison for biological screening. The structures of compounds 1-6, along with three related known analogues 7-9, were determined on the basis of extensive spectroscopic analysis and by comparison with literature data.

An iridoid glucoside and the related aglycones from Cornus florida.

A new iridoid glucoside, cornusoside A (1), and four new natural product iridoid aglycones, cornolactones A-D (2-5), together with 10 known compounds were isolated from the leaves of Cornus florida. The structures of compounds 1-5 were established by interpretation of their spectroscopic data. Cornolactone B (3) is the first natural cis-fused tricyclic dilactone iridoid containing both a five- and a six-membered lactone ring.

Liver X receptor and peroxisome proliferator-activated receptor agonist from Cornus alternifolia.

Background: Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptors superfamily and are transcription factors activated by specific ligands. Liver X receptors (LXR) belong to the nuclear hormone receptors and have been shown to play an important role in cholesterol homeostasis. From the previous screening of several medicinal plants for potential partial PPARγ agonists, the extracts of Cornus alternifolia were found to exhibit promising bioactivity.

Diterpenoid alkaloids from a Tibetan medicinal plant var. and their cytotoxic activity.

The chemical constituents from var. were investigated. The roots of this plant were extracted three times with 90% EtOH at the room temperature.

[Study on chemical constituents from Delphinium honanense var. piliteram].

Objective: To study the chemical constituents from Delphinium honanense var. piliteram.

Method: The constituents were isolated and purified with chromatographic methods, identified by NMR, MS and IR.

A new norditerpenoid alkaloid from Aconitum taipaicum.

To investigate the chemical constituents of the roots of Aconitum taipaicum, silica gel column chromatography was used for the isolation and purification of compounds. A new norditerpenoid alkaloid, isodelelatine (1), along with five known alkaloids, atisine (2), delfissinol (3), liangshanine (4), hypaconitine (5) and delelatine (6) were isolated and identified. The structure of the new compound was elucidated on the basis of spectral data.

[Studies on chemical constituents in leafs of Clerodendron fragrans].

Objective: To separate and identify the constituents from Clerodendron fragrans.

Method: The constituents were isolated and purified with chromatographic methods, identified by NMR, MS, IR.

Result: Beta-sitosterol (1), clerosterol (2), daucosterol (3), caffeic acid (4), kaempferol (5), 5,4'-dihydroxy-kaempferol-7-O-beta-rutinoside (6), acteoside (7) and leucoseceptoside A (8), were isolated and identified.

[Studies on chemical constituents of Clerodendrum bungei].

Objective: To study the constituents from Clerodendrum bungei.

Method: The constituents were isolated and purified with chromatographic methods, and identified by NMR, MS and IR.

Result: Five compounds were isolated, beta-sitosterol (1), taraxerol (2), glochidone (3), glochidonol (4), glochidiol (5).