Publications by authors named "Yangqiang Chen"
Article Synopsis
- Aberrant activation of the Wnt/β-catenin signaling pathway is linked to tumor development, and targeting the β-catenin/BCL9 interaction could be an effective anti-cancer strategy.
- The study introduces two new variations of β-catenin and analyzes how their structural changes at the BCL9 binding site affect potential drug binding.
- A class of novel compounds was identified that show strong inhibition of β-catenin/BCL9 interactions and improve immune responses in cancer, potentially overcoming resistance to immunotherapy.
