Y-Balance Test performance for predicting plantar fasciitis in male recreational marathon runners: a prospective cohort study.

Background: Plantar fasciitis (PF) is the third most common type of running-related overuse injury. The purpose of this study was to investigate whether the performance of the Y-balance test (YBT) could predict PF development in male recreational marathon runners.

Methods: One hundred and seventy-two male recreational marathon runners underwent the YBT and were then tracked for PF development during a 3-month period.

Comparative analysis of the effects of gender on lower extremity kinematics following a 5 km running time trial in collegiate recreational runners.

To explore whether collegiate recreational runners of different genders exhibit different lower extremity kinematics following a 5 km running time trial. Thirty collegiate recreational runners (15 males, 15 females) participated. The participants performed kinematic tests using IMUs before and after the 5 km running time trial.

p85α deficiency alleviates ischemia-reperfusion injury by promoting cardiomyocyte survival.

Myocardial ischemia-reperfusion (I/R) injury is a prevalent cause of myocardial injury, involving a series of interconnected pathophysiological processes. However, there is currently no clinical therapy for effectively mitigating myocardial I/R injury. Here, we show that p85α protein levels increase in response to I/R injury through a comprehensive analysis of cardiac proteomics, and confirm this in the I/R-injured murine heart and failing human myocardium.

Rocaglamide promotes infiltration and differentiation of T cells and coordinates with PD-1 inhibitor to overcome checkpoint resistance in multiple tumor models.

Tumor-infiltrating lymphocyte (TIL) deficiency is the most conspicuous obstacle to limit the cancer immunotherapy. Immune checkpoint inhibitors (ICIs), such as anti-PD-1 antibody, have achieved great success in clinical practice. However, due to the limitation of response rates of ICIs, some patients fail to benefit from monotherapy.

Traditional Chinese Medicine for Cancer Treatment.

In recent years, due to advancements in medical conditions and the development of scientific research, the fundamental research of TCM antitumor treatments has progressed from the cellular level to the molecular and genetic levels. Previous studies have demonstrated the significant role of traditional Chinese medicine (TCM) in antitumor therapy through various mechanisms and pathways. Its mechanism of action is closely associated with cancer biology across different stages.

Preparation of Superhydrophobic Coating on X80 Steel and Its Corrosion Resistance in Oilfield Produced Water.

Corrosion is an unavoidable issue that steel encounters during service; however, the generic methods employed for corrosion prevention often need high cost or preparation conditions. In this study, a facile chemical replacement deposition method was proposed to realize an anticorrosion superhydrophobic coating on a X80 steel surface. The growth mechanism of the rough structure and its impact on the wettability of the superhydrophobic coating were analyzed.

Rocaglamide regulates iron homeostasis by suppressing hepcidin expression.

The anemia of inflammation (AI) is characterized by the presence of inflammation and abnormal elevation of hepcidin. Accumulating evidence has proved that Rocaglamide (RocA) was involved in inflammation regulation. Nevertheless, the role of RocA in AI, especially in iron metabolism, has not been investigated, and its underlying mechanism remains elusive.

Effect of overweight/obesity on relationship between fractional exhaled nitric oxide and airway hyperresponsiveness in Chinese elderly patients with asthma.

This retrospective study investigates the influence of overweight and obesity status on pulmonary function, airway inflammatory markers, and airway responsiveness in elderly asthma patients. Patients with asthma older than 65 years old who completed a bronchial provocation test (BPT) or bronchial dilation test (BDT) and a fractional exhaled nitric oxide (FeNO) test between December 2015 and June 2020 were identified retrospectively for this study. All of the patients were categorized into overweight/obesity and non-obesity groups based on their BMI.

Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions.

Background And Objective: Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel biomarker for identifying the increased risk of adverse cardiovascular events. This study aims to investigate the association of NP with endothelial dysfunction and impaired lung function in COPD, asthma, and ACO patients.

Ailanthone inhibits non-small cell lung cancer growth and metastasis through targeting UPF1/GAS5/ULK1 signaling pathway.

Background: Targeting long non-coding RNAs (LncRNAs) is a novel and promising approach in cancer therapy. In our previous study, we investigated the effects of ailanthone (aila), the main active compound derived from the stem barks of Ailanthus altissima (Mill.) Swingle, on the growth of non-small cell lung cancer (NSCLC) cells.

Corrosion Inhibition Mechanism of Water-Soluble Imidazoline on A572 Gr.65 Steel in 3.5 wt % NaCl Solution.

To optimize the economic advantages and corrosion-resisting property of A572 Gr.65 steels, the inhibition effect of water-soluble imidazoline on the sample surface with rare earth was explored in a 3.5 wt % NaCl solution.

Simultaneous evaluation of the fractional exhaled nitric oxide and blood eosinophil count of T2-high endotype in patients with non-cystic fibrosis bronchiectasis.

Objective: Recently, a type 2 inflammation (T2) high endotype in bronchiectasis was identified. The fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (BEC) are recognized as representative biomarkers of T2 inflammation. Herein, we investigate the clinical characteristics of T2-high endotype in non-cystic fibrosis bronchiectasis patients classified by FeNO and BEC.

Two sensory neurons coordinate the systemic mitochondrial stress response via GPCR signaling in C. elegans.

Mitochondrial perturbations within neurons communicate stress signals to peripheral tissues, coordinating organismal-wide mitochondrial homeostasis for optimal fitness. However, the neuronal control of the systemic stress regulation remains poorly understood. Here, we identified a G-protein-coupled receptor (GPCR), SRZ-75, that couples with Gαq signaling in a pair of chemosensory ADL neurons to drive the mitochondrial unfolded protein response (UPR) activation in the intestine via the release of neuropeptides in Caenorhabditis elegans.

Novel DNA Promoter Hypermethylation in Nasal Epithelium of Asthma.

Background: Abnormal epigenetic alterations influenced by external factors and affecting DNA expression contribute to the development of asthma. However, the role of the nasal epithelium in airway inflammation remains unknown.

Objective: The objective of this study is to identify novel DNA promoter hypermethylation, which suppresses mRNA expression in nasal epithelial of asthma.

Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPR activation and lifespan extension in C. elegans.

Coordination of inter-tissue stress signaling is essential for organismal fitness. Neuronal mitochondrial perturbations activate the mitochondrial unfolded-protein response (UPR) in the intestine via the mitokine Wnt signaling in Caenorhabditis elegans. Here, we found that the protein disulfide isomerase PDI-6 coordinates inter-tissue UPR signaling via regulating the Wnt ligand EGL-20.

Corrigendum: The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma.

[This corrects the article DOI: 10.3389/fgene.2022.

The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma.

RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation. We selected 26 RNA modification "writers" of lung adenocarcinoma (LUAD) samples and performed unsupervised clustering analysis to explore RNA modification patterns in LUAD.

Dietary induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in .

Dietary and symbiotic bacteria can exert powerful influence on metazoan lipid metabolism. Recent studies have emerged that microbiota have a role in animal obesity and related health disorders, but the mechanisms by which bacteria influence lipid storage in their host are unknown. To reduce the complexity of the relationship between gut microbiota and the host, () has been chosen as a model organism to study interspecies interaction.

Acute fibrinous and organizing pfneumonia: two case reports and literature review.

Background: Acute fibrinous and organizing pneumonia (AFOP) is a rare histologic interstitial pneumonia pattern characterized by the intra-alveolar fibrin deposition and organizing pneumonia. Its clinical characteristics are still not well known and there is no consensus on treatment yet.

Case Presentation: We report two female cases in their fifties diagnosed with AFOP confirmed by a second lung biopsy.

The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels.

The memory of stresses experienced by parents can be passed on to descendants as a forecast of the challenges to come. Here, we discovered that the neuronal mitochondrial perturbation-induced systemic mitochondrial unfolded protein response (UPR) in Caenorhabditis elegans can be transmitted to offspring over multiple generations. The transgenerational activation of UPR is mediated by maternal inheritance of elevated levels of mitochondrial DNA (mtDNA), which causes the proteostasis stress within mitochondria.

A computed tomography (CT)-derived radiomics approach for predicting primary co-mutations involving and epidermal growth factor receptor () in patients with advanced lung adenocarcinomas (LUAD).

Background: Epidermal growth factor receptor () co-mutated with could reduce responsiveness to tyrosine kinase inhibitors (TKIs) and worsen patients' prognosis compared to wild type patients in.

Egfr: mutated lung adenocarcinomas (LUAD). To identify this genetically unique subset prior to treatment through computed tomography (CT) images had not been reported yet.

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19.

Background: The lack of knowledge regarding the pathogenesis and host immune response during SARS-CoV-2 infection has limited the development of effective treatments. Thus, we longitudinally investigated the dynamic changes in peripheral blood lymphocyte subsets and parallel changes in cytokine levels in COVID-19 patients with different disease severities to further address disease pathogenesis.

Methods: A total of 67 patients (10 moderate, 38 severe and 19 critical cases) with COVID-19 admitted to a tertiary care hospital in Wuhan from February 8th to April 6th, 2020 were retrospectively studied.