Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia.

Acute and chronic exposure to high altitude causes multiple negative neurological consequences. Further research has shown the efficacy of targeted drugs after acute hypoxia. However, the effects and mechanisms of physical therapy like exercise, on after exposed-induced myelin repair and functional improvements have remained unclear.

Association of electrocardiogram features with risk of obstructed sleep apnea: a population-based cohort study.

Background: There is limited investigation on the longitudinal association between common electrocardiogram (ECG) features and the incidence of obstructive sleep apnea (OSA). This study aimed to examine the association of common ECG features with the incidence of OSA in a prospective cohort.

Methods: 2,563 participants aged 60 years or more were selected from the baseline survey of the Guangzhou Heart Study.

Treadmill exercise supplemented by OPN promote axon regeneration through the IGF-1R/Akt/mTOR signaling pathway.

Regeneration of the corticospinal tract (CST) is considered a therapeutic target to achieve improved recovery of motor function after spinal cord injury (SCI), which is an incurable CNS damage that affects millions of people. Exercise training is effective in improving multiple functions in spinal cord-injured patients. However, the effects of exercise training on axon regeneration have not been sufficiently reported.

The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1.

Purpose: This study aimed to investigate the molecular links and mechanisms between Crohn's disease (CD) and colorectal cancer (CRC).

Methods: This study used the Gene Expression Omnibus (GEO) database to identify Differentially expressed genes (DEGs) in CD (GSE112366) and CRC (GSE110224), analyzed by 'edgeR' and 'limma'. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes explored DEG functions, and the Search Tool for the Retrieval of Interacting Genes (STRING) informed the protein-protein interaction network construction visualized in Cytoscape (version 3.

Effects of task-based mirror therapy on upper limb motor function in hemiplegia: study protocol for a randomized controlled clinical trial.

Background And Purpose: Research to date has lacked definitive evidence to determine whether mirror therapy promotes the recovery of upper extremity function after stroke. Considering that previous studies did not stratify patients based on structural retention, this may be one of the reasons for the negative results obtained in many trials. The goal evaluates the efficacy of TBMT (utilizing an innovatively designed mirror) versus standard occupational therapy for stroke patient's upper limb functionality.

Adhesive Carbon Paste Electrode for Convenient and Long-term Electrocardiogram Monitoring: A Pilot Study.

Long-term electrocardiogram (ECG) monitoring is an important and widely-used technique in the clinic that helps with the diagnosis of possible diseases that cannot be detected in a short time monitoring. However, the clinically used electrode needs conductive gel to reduce the impedance between the skin and the electrodes, which easily causes the possibility of allergy. Moreover, as the conductive gel becomes dry, the signal's quality will decrease accordingly.

Deacetylation of chitin oligomers by Fusarium graminearum polysaccharide deacetylase suppresses plant immunity.

Chitin is a long-chain polymer of β-1,4-linked N-acetylglucosamine that forms rigid microfibrils to maintain the hyphal form and protect it from host attacks. Chitin oligomers are first recognized by the plant receptors in the apoplast region, priming the plant's immune system. Here, seven polysaccharide deacetylases (PDAs) were identified and their activities on chitin substrates were investigated via systematic characterization of the PDA family from Fusarium graminearum.

Characteristics of clinical trials for non-small cell lung cancer therapeutic vaccines registered on ClinicalTrials.gov.

Background: Even after complete surgical treatment or chemotherapy, Non-Small Cell Lung Cancer (NSCLC) patients are also at substantial risk for recurrence and spread trend. Therapeutic cancer vaccination could increase the anti-tumor immune response and prevent tumor relapse. This study aimed to assess the characteristics of NSCLC therapeutic vaccines registered on ClinicalTrials.

Flexible Non-contact Electrodes for Wearable Biosensors System on Electrocardiogram Monitoring in Motion.

Electrocardiogram (ECG) is a critical physiological indicator that contains abundant information about human heart activities. However, it is a kind of weak low-frequency signal, which is easy to be interfered by various noises. Therefore, wearable biosensors (WBS) technique is introduced to overcome this challenge.

Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells.

Organophosphate flame retardants (OPFRs) have been ubiquitously detected in dust and air which could cause damage to human health through inhalation. Currently the understanding of their adverse effects and potential mechanisms on the lung are still limited. In this study, human non-small cell lung cancer cell line NCI-H1975 was used to investigate the cytotoxicity, oxidative stress, cellular apoptosis of 9 typical OPFRs with concentrations varied from 0 to 200 μM, and their toxic mechanism associated with molecular structure was compared.

A Pilot Study on Long-term Physiological Signal Monitoring using Anhydrous Viscoplastic Electrodes.

Electrocardiography (ECG) and Electromyogram (EMG) are widely used to help physicians to diagnose various diseases. Besides, long-term physiological signals monitoring is of great significance for circumstances where certain diseases may not be observed in short-term monitoring. At present, wet electrodes are widely used in the clinic and are considered as a standard method to acquire physiological signals in high fidelity.

Enhanced ammonia adsorption and separation by a molecularly imprinted polymer after acid hydrolysis of its ester crosslinker.

While ammonia (NH) is one of the primary hazardous emissions from sludge aerobic composting plants, it has the potential to be recycled as an energy source or nitrogen fertilizer. Recently, an NH molecularly imprinted polymer (NH-MIP) was developed that efficiently separated NH from other compounds, but its adsorption capacity required improvement. This study improved both NH adsorption capacity and separation of the NH-MIP using acid hydrolysis optimization.

TRC-Based High-Precision Spot Position Detection in Inter-Satellite Laser Communication.

Inter-satellite laser communication (Is-OWC) is one of the main space optical communication technologies currently studied in various countries. In recent years, a kind of Is-OWC communication terminal without independent beacon light has appeared. Such terminals do not have a separate beacon laser with a large divergence angle, but use a narrower communication beam to complete space capture and tracking.

Correction: Preparation of electrospray ALG/PDA-PVP nanocomposites and their application in cancer therapy.

Correction for 'Preparation of electrospray ALG/PDA-PVP nanocomposites and their application in cancer therapy' by Yangjie Xu et al., Soft Matter, 2020, 16, 132-141.

Synthesis of ammonia molecularly imprinted adsorbents and ammonia adsorption separation during sludge aerobic composting.

Ammonia (NH) is the predominant harmful odor emitted from sludge aerobic composting plants, however, this NH could be recycled and used as energy or nitrogen fertilizer. Therefore, the aim of this study was to use molecular imprinting technology to prepare an adsorbent that could separate NH from mixed gases. An NH molecular imprinted polymer (NH-MIP) was prepared by precipitation polymerization and optimal synthesis was determined by testing several different ratios of reaction components.

Preparation of electrospray ALG/PDA-PVP nanocomposites and their application in cancer therapy.

In this study, sodium alginate (ALG)/poly dopamine (PDA)-polyvinylpyrrolidone (PVP) nanocomposites was synthesized via a one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into an alkaline solution of PVP, calcium chloride and tris buffer (pH = 8.5), in which the gelation of ALG and the polymerization of dopamine could be simultaneously triggered.

An Improved Method of Measuring Wavefront Aberration Based on Image with Machine Learning in Free Space Optical Communication.

In this paper, an improved method of measuring wavefront aberration based on image with machine learning is proposed. This method had better real-time performance and higher estimation accuracy in free space optical communication in cases of strong atmospheric turbulence. We demonstrated that the network we optimized could use the point spread functions (PSFs) at a defocused plane to calculate the corresponding Zernike coefficients accurately.

Improved Machine Learning Approach for Wavefront Sensing.

In the adaptive optics (AO) system, to improve the effectiveness and accuracy of wavefront sensing-less technology, a phase-based sensing approach using machine learning is proposed. In contrast to the traditional gradient-based optimization methods, the model we designed is based on an improved convolutional neural network. Specifically, the deconvolution layer, which reconstructs unknown input by measuring output, is introduced to represent the phase maps of the point spread functions at the in focus and defocus planes.

Piston sensing of sparse aperture systems with a single broadband image via deep learning.

The pistons of sparse aperture systems need to be controlled within a fraction of a wavelength for the system's optimal imaging performance. In this paper, we demonstrate that deep learning is capable of performing piston sensing with a single wide-band image after appropriate training. Taking the sensing issue as a fitting task, the deep learning-based method utilizes a deep convolutional neural network to learn complex input-output mapping relations between the broadband intensity distributions and corresponding piston values.

Emission characteristics of volatile sulfur compounds (VSCs) from a municipal sewage sludge aerobic composting plant.

The emission of volatile sulfur compounds (VSCs) causing strong odors is a major problem in municipal sewage sludge composting plants (MSSACPs). Improving the knowledge on characteristics of VSCs emission in MSAACPs is of particular significance to elimate odors, but the studies conducted on-site to identify them are scarce. To this purpose, characteristics of VSCs emission were studied on-site from a MSSACP during different ambient temperatures corresponding with seasonal variations.

Curcumin reverses irinotecan resistance in colon cancer cell by regulation of epithelial-mesenchymal transition.

The objective of this study was to investigate the effect and the mechanism by which curcumin reverses irinotecan-induced chemotherapy resistance in colon cancer. Construction of irinotecan-resistant colon cancer model LoVo/CPT-11R cells was performed by increasing drug concentration. The Cell Counting Kit-8 assay was used to detect inhibition of proliferation; cell morphology was observed by an optical microscope.